A5049197436- Advanced Glycation End Products research
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Fatty Acid Research and Health
- S100 Proteins and Annexins
- Metabolism, Diabetes, and Cancer
- Biocrusts and Microbial Ecology
- Natural Antidiabetic Agents Studies
- Sulfur Compounds in Biology
- Aquatic Ecosystems and Phytoplankton Dynamics
- Marine Toxins and Detection Methods
- Glycosylation and Glycoproteins Research
- Diet, Metabolism, and Disease
Banaras Hindu University
2019-2024
Indian Institute of Technology BHU
2023-2024
Biotechnology Institute
2023
Liver cancer is fourth leading cause of deaths worldwide. Urethane presents in herbicides, pesticides and food beverages as preservatives upregulate the expression inflammatory cytokines liver tissues for genesis cancer. It also naturally formed fermented products distilled beverages. Balb/c mice approx same age body weight were selected divided into four groups G-I (PBS treated), G-II (urethane 500 mg/kgb.w.), G-III (CGA 50mg/kg b.w.) G-IV & CGA). Treatments given on alternate day upto...
Recently, High Mobility Group Box1 (HMGB1) protein has been reported as an inflammatory cytokine present in all nucleated cells with crucial role the genesis and promotion of cancer. No HMGB1 mice model its active site details are available to validate vivo experiments. Here, for first time we have silico using human template. Prepared secondary structure showed 6-α helices, 5-β turns, 2-γ turns 67% α-helices, 32% coil 9% turn without β-sheet, classified α-class protein. Ramachandran plot...
Abstract IRSs are cytoplasmic-skeleton proteins. It facilitates RTK signaling through insulin/IGF-1, insulin receptor, and Src-homology-2-domains. IRS1 is a cytoplasmic adaptor protein that helps in cellular growth, glucose metabolism, proliferation, differentiation. disordered with hard-to-predict active site. Here we used the ab-initio modeling tool I-Tasser Discovery studio/DogSite server to model determine site of human (mol. wt. 131590.97Da) respectively. Newly designed submitted PMDB...