A5083997665- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Alzheimer's disease research and treatments
- Trace Elements in Health
- Prion Diseases and Protein Misfolding
- Bacterial biofilms and quorum sensing
- Cell Image Analysis Techniques
- Selenium in Biological Systems
- Essential Oils and Antimicrobial Activity
- Advanced Chemical Sensor Technologies
- Spaceflight effects on biology
- Computational Drug Discovery Methods
- Field-Flow Fractionation Techniques
New York University
2022
Engelhardt Institute of Molecular Biology
2014-2021
Genetika
2014
In previous research, volatile organic compounds (VOCs) emitted by various bacteria into the chemosphere were suggested to play a significant role in antagonistic interactions between microorganisms occupying same ecological niche and target eukaryotes. Moreover, number of volatiles released reported suppress quorum-sensing cell-to-cell communication bacteria, stimulate plant growth. Here, produced Pseudomonas Serratia strains isolated mainly from soil or rhizosphere exhibited bacteriostatic...
Abstract A high-sugar diet has been associated with reduced lifespan in organisms ranging from worms to mammals. However, the mechanisms underlying harmful effects of glucose are poorly understood. Here we establish a causative relationship between endogenous storage form glycogen, resistance oxidative stress and organismal aging Caenorhabditis elegans. We find that glycogen accumulated on high dietary limits C. elegans longevity. Glucose released used for NADPH/glutathione reduction renders...
Abstract Glutathione (GSH) is the most abundant cellular antioxidant. As reactive oxygen species (ROS) are widely believed to promote aging and age-related diseases, antioxidants can neutralize ROS, it follows that GSH its precursor, N-acetyl cysteine (NAC), among popular dietary supplements. However, long- term effects of or NAC on healthy animals have not been thoroughly investigated. We employed C. elegans demonstrate chronic administration young aged perturbs global gene expression,...
The pathogenesis of Alzheimer's disease (AD) is associated with the formation cerebral amyloid plaques, main components which are modified Aβ molecules as well metal ions. isomerized at Asp7 residue (isoD7-Aβ) most abundant isoform in plaques. We hypothesized that pathogenic effect isoD7-Aβ due to zinc-dependent oligomers, and this interaction can be disrupted by rationally designed tetrapeptide (HAEE). Here, we utilized surface plasmon resonance, nuclear magnetic molecular dynamics...