A5050298916- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Malaria Research and Control
- Viral Infections and Outbreaks Research
- vaccines and immunoinformatics approaches
- Vector-borne infectious diseases
- Insect symbiosis and bacterial influences
- Parasites and Host Interactions
- Advertising and Communication Studies
- Synthesis and Biological Evaluation
- COVID-19 Clinical Research Studies
- Virology and Viral Diseases
- Insect and Pesticide Research
- Infectious Encephalopathies and Encephalitis
- interferon and immune responses
Mexican Social Security Institute
2009-2023
Instituto Nacional de Salud Pública
2003-2009
Universidad Juárez Autónoma de Tabasco
2008
Autonomous University of Yucatán
2005-2007
Icahn School of Medicine at Mount Sinai
2003
Dengue virus is a worldwide-distributed mosquito-borne flavivirus with positive strand RNA genome. Its transcribed polyprotein cleaved by host- and virus-encoded peptidases into 10 proteins, some of which are unknown function. Although dengue virus-infected cells seem to be resistant the antiviral action IFN, viral products that mediate this resistance unknown. Therefore, we have analyzed ability proteins antagonize IFN response. We found expression in human A549 nonstructural NS2A, NS4A, or...
Background: There is a lack of specific antiviral therapy against dengue virus (DENV) in current use. Therefore, great proportion cases progress to severe clinical forms due complex interplay between and host immune response. It has been hypothesized that heterotypic non-neutralizing antibodies enhance DENV infection phagocytic cells, this induces an inflammatory response involved the pathogenesis dengue. Purpose: To identify immunomodulatory effects polyphenols on infection. Methods: Human...
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major public health problem in most of Latin America. A key priority development new treatments, due to poor efficacy current ones. We report here comparative evaluation therapeutic DNA vaccines encoding various T. cruzi antigens. ICR mice infected with 500 parasites intraperitoneally were treated at 5 and 12 days postinfection 20 µg plasmid antigens TSA-1, TS, ASP-2-like, Tc52 or Tc24. Treatment TS and/or ASP-2-like...
OBJETIVO: Determinar la seroprevalencia de anticuerpos neutralizantes los serotipos del virus dengue en estudiantes universitarios Tabasco, México, durante meses septiembre a noviembre año 2005. MATERIAL Y MÉTODOS: Se determinó presencia IgG contra el suero que acudieron al centro clínico universidad; sueros positivos se determinaron mediante ensayo reducción placa lítica. RESULTADOS: La prevalencia fue 9.1%; esta proporción, fueron DENV-1 (20%), DENV-2 (100%), DENV-3 (4%) y DENV-4 (68%)....
Dengue virus encephalopathy was experimentally induced in newborn mice by i.p. inoculation of dengue 2 virus. At 6 and 9 days post-infection, motor incoordination posterior limb paralysis were observed with focal necrosis, apoptotic cells, perivascular inflammatory cuffing astrocytosis, mainly the cortex hippocampus. Expression genome mRNA encoding for TNF-alpha, IL-1alpha, IL-2, IL-6, IL-1beta, IL-12 p40, IFNalpha, IFNbeta; addition host survival response genes MAC-1, EB22, GFAP, ICAM-1...
The disease burden of arthropod-borne infections is particularly high in low- and middle-income countries, where the availability resources for surveillance testing limited. lack local infrastructure demands that biological samples be sent to central laboratories by refrigerated transport, which increases costs risk sample degradation. Dried blood spot are an alternative ensuring integrity during transportation storage. They can used detection nucleic acids proteins, such as antigens or...
Reverse vaccinology is an outstanding strategy to identify antigens with high potential for vaccine development. Different parameters of five prediction programs were used assess their sensitivity and specificity B-cell epitopes Chikungunya virus (CHIKV) strains reported in the IEDB database. The results, based on use 15 20 mer polyproteins which they belong, compared establish best optimize antigenic peptides Mexican strain CHIKV AJV21562.1. LBtope showed highest when we but worst...
It is acknowledged that antiviral immune response contributes to dengue immunopathogenesis. To identify immunological markers distinguish fever (DF) and hemorrhagic (DHF), 113 patients with confirmed infection were analyzed at 6 or 7 days after onset. Peripheral blood mononuclear cells (PBMC) isolated, lymphocyte subsets activation biomarkers identified by flow cytometry, differentiation of T helper (Th) lymphocytes was achieved the relative expression analysis T-bet (Th1), GATA-3 (Th2),...
Con el desarrollo de la primera vacuna contra viruela por médico rural Edward Jenner en 1976, surgió una las estrategias más efectivas prevenir o erradicar infecciones varios patógenos como los virus viruela, poliovirus tipo 2 y 3. Sin embargo, también surgieron críticas acciones aplicación tales formas protección cura diversas enfermedades (aún mostrando capacidad para controlarlas). Entre años 60s 80s preocupaciones respecto a potenciales efectos adversos complicaciones neurológicas...
The antigenic potential of seven immunogenic peptides the dengue virus was evaluated in sera patients with confirmed by IgM/IgG serology. Antibodies IgM and IgG against were analyzed ELISA 31 sero-positive 20 sero-negative patients. P5 peptide showed significant immunoreactivity mostly without warning signs comparison signs, correlating mild disease. This finding suggests that low antibody response epitope could be a risk factor for higher susceptibility to infection antigen vaccine development.
Introduction: Previous studies that identified the prognostic factors for severity of new coronavirus disease 2019 (COVID-19) in different populations have generated controversial conclusions. The lack a standard definition COVID-19 and differences between clinical diagnoses might make it difficult to provide optimum care according characteristics each population. Methodology: We investigated impacted severe outcome or death from acute respiratory syndrome 2 (SARS-CoV-2) infection patients...