A5023892001- Bladder and Urothelial Cancer Treatments
- Particle physics theoretical and experimental studies
- Urological Disorders and Treatments
- Nanoplatforms for cancer theranostics
- Laser-Plasma Interactions and Diagnostics
- High-Energy Particle Collisions Research
- Urinary and Genital Oncology Studies
- Photodynamic Therapy Research Studies
- Higher Education Research Studies
- Cancer Immunotherapy and Biomarkers
- Nuclear Physics and Applications
- Epigenetics and DNA Methylation
- Sexual function and dysfunction studies
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- Infectious Disease Case Reports and Treatments
- Quantum Chromodynamics and Particle Interactions
- Genital Health and Disease
- Higher Education Governance and Development
- Labor market dynamics and wage inequality
- CAR-T cell therapy research
- Urologic and reproductive health conditions
- Urinary Bladder and Prostate Research
SUNY Upstate Medical University
2012-2020
Syracuse University
2020
Center for Cancer Research
2010-2020
National Institutes of Health Clinical Center
2020
National Cancer Institute
2010-2020
National Institutes of Health
2010-2020
Accreditation Council for Graduate Medical Education
2018
Minnesota Office of Higher Education
2018
University of California, San Francisco
2013-2018
Office of Education
2018
As the architect of oldest and most stable performance funding program, Tennessee provides a unique opportunity to analyze impact changes in policies on institutional retention six-year graduation rates over time. Utilizing spline linear mixed models, this study examines Tennessee’s at public four-year institutions from 1995-2009. The results show tying was unrelated measures fifteen year period examined. Additionally, doubling monetary incentive associated with rate 2005 not increases...
The use of light as a means therapy for bladder cancer has long history but been hampered by lack tumor specificity and therefore, damage to the normal mucosa. Here, we describe targeted form phototherapy called photoimmunotherapy (PIT), which targets EGFR-expressing cancer. Anti-EGFR antibody panitumumab was labeled with photoabsorber (PA), IRDye 700Dx (IR700), create panitumumab-IR700 antibody-PA conjugate that is activated near-infrared radiation (NIR). Bladder tissue microarray (TMA)...
Abstract Bladder cancer (BC) is heterogeneous and expresses various cell surface targets. Photoimmunotherapy (PIT) involves monoclonal antibodies (MAbs) conjugated to a photoabsorber (PA), IR Dye 700Dx, then activated by near infra-red light (NIR) specifically target tumors. We have demonstrated that tumors expressing EGFR can be targeted with PIT. However, PIT may less effective when tumor lacks “overwhelming” expression of single such as EGFR. present combinatorial approach for targeting...
Heat shock protein 90 (HSP90) inhibition is an attractive strategy for cancer treatment. Several HSP90 inhibitors have shown promising effects in clinical oncology trials. However, little known about inhibition-mediated bladder therapy. Here, we report a quantitative proteomic study that evaluates alterations expression and histone post-translational modifications (PTMs) carcinoma response to inhibition. We show 5 (AUY922, ganetespib, SNX2112, AT13387, CUDC305) potently inhibited the...
Cycling is associated with many health benefits, but also the risk of injury.Trends in bicycle-related injuries are difficult to assess because majority nonfatal sustained while cycling not reported police and thus included traffic statistics. 1 We sought evaluate trends adult hospital admissions United States using emergency department data.Methods | The National Electronic Injury Surveillance System (NEISS) a national probability sample approximately 100 departments that gathers...
AbstractThe long-range goal of the Z-Pinch IFE program is to produce an economically-attractive power plant using high-yield z-pinch-driven targets (~3GJ) with low rep-rate per chamber (~0.1 Hz). The present mainline choice for a uses LTD (Linear Transformer Driver) repetitive pulsed driver, Recyclable Transmission Line (RTL), dynamic hohlraum target, and thick-liquid wall chamber. RTL connects driver directly made from frozen coolant or material that easily separable (such as carbon steel)....
Introduction Prior studies have shown genetic similarities between upper tract and bladder urothelial carcinoma. However, carcinoma tends to be higher grade than form in patients with certain familial conditions (e.g. Lynch Syndrome), indicating there may unique biologic processes these tumors. The purpose of this study was evaluate the differences gene expression using microarray data. Design, Setting, Participants A search publicly available datasets identified a clinically annotated...
Abstract Purpose: Previous studies have shown that ischemia alters gene expression in normal and malignant tissues. There are no evaluated effects of renal tumors. This study examines the impact tissue procurement conditions on RNA integrity cell carcinoma. Experimental Design: Ten tumors were resected without hilar clamping from 10 patients with clear Immediately after tumor resection, a piece was snap frozen. Remaining samples stored at 4°C, 22°C, 37°C frozen 5, 30, 60, 120, 240 minutes....
Prompt dimuon production has been measured. Events with mass up to 25 ${\mathrm{G}\mathrm{e}\mathrm{V}/\mathit{c}}^{2}$ are observed, as well the $J$ and $\ensuremath{\Upsilon}$ resonances. Cross sections given for production. For continuum, scaling function $F(\ensuremath{\tau})$ is measured at very small values of $\sqrt{\ensuremath{\tau}}=\frac{m}{\sqrt{s}}$ covering range $0.05<\sqrt{\ensuremath{\tau}}<0.20$.
Patients with hereditary renal cancer are at increased risk for recurrent bilateral multifocal tumors and may require aggressive nephron sparing surgery to prevent replacement therapy. We evaluated feasibility outcomes in patients who underwent partial nephrectomy removal of least 20 a single unit 1 setting.
Emergency department visits and hospital admissions resulting from adult bicycle trauma have increased dramatically. Annual medical costs work losses of these incidents last were estimated for 2005 quality-of-life 2000.We associated with injuries in the USA using 1997-2013 non-fatal incidence data National Electronic Injury Surveillance System cost estimates Consumer Product Safety Commission's Cost Model, 1999-2013 fatal Vital Statistics costed by similar methods.Approximately 3.8 million...
Elucidation of epigenetic alterations in bladder cancer will lead to further understanding the biology disease and hopefully improved therapies. Our aim was perform an integrative analysis invasive urothelial carcinoma identify abnormalities involved development progression this cancer. Pre-processed methylation data RNA-seq were downloaded from The Cancer Genome Atlas (TCGA) processed using R package TCGA-Assembler. An MethylMix used incorporating both gene expression on all samples, as...
Several surgical techniques are available to treat anterior urethral stricture. The choice of technique largely depends on the severity stricture disease. U-score (urethral score) is based characteristics, namely length (1 3 points), number or 2 location points) and etiology which tallied provide a total score 4 9 points. Our aim was identify whether system predictive complexity outcome urethroplasty.We retrospectively reviewed records all patients who underwent urethroplasty from 2002 2012...
Emphysematous pyelonephritis is a severe infection of the kidney associated with formation gas in renal parenchyma and/or collecting system. The purpose this study was to evaluate outcomes patients emphysematous contemporary cohort and impact urolithiasis on disease severity.A search all imaging reports at University California San Francisco (UCSF) for term "emphysematous pyelonephritis" undertaken from 2003-2014. Patients were included if there clinical evidence infection, no recent...
A previous study conducted a decade ago determined that there can be considerable disagreementnot only between students and faculty, but also among facultyregarding behaviors constitute cheating. This article reports the results of research replicated student survey administered for study, with changes in questionnaire to reflect how technology has become infused teaching assessment learning. Recommendations preventing academic dishonesty are provided.