A5086459849- Influenza Virus Research Studies
- Respiratory viral infections research
- Protein Structure and Dynamics
- Animal Disease Management and Epidemiology
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Bacillus and Francisella bacterial research
- Gut microbiota and health
- Tuberculosis Research and Epidemiology
- Poxvirus research and outbreaks
- Virology and Viral Diseases
- Reproductive tract infections research
- Bacteriophages and microbial interactions
- Malaria Research and Control
- Antibiotic Resistance in Bacteria
- Immune Response and Inflammation
- Cervical Cancer and HPV Research
- Polyamine Metabolism and Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Vibrio bacteria research studies
Instituto Politécnico Nacional
2009-2024
Center for Biologics Evaluation and Research
2011
United States Food and Drug Administration
2010
Zika virus (ZIKV) is an emerging flavivirus that represents significant public health challenges, particularly in the Americas, and a substantial risk to other parts of world due its rapid expansion established association with neurological disorders, including Guillain–Barré syndrome intrauterine fetal infection can cause microcephaly, blindness, congenital complications. To date, no vaccine prevent ZIKV infections has been approved. Therefore, developing safe effective against this global...
The influenza virus hemagglutinin (HA) envelope protein mediates entry by first binding to cell surface receptors and then fusing viral endosomal membranes during endocytosis. Cleavage of the HA precursor (HA0) into a receptor-binding subunit (HA1) fusion-inducing transmembrane (HA2) host enzymes primes for fusion competence repositioning peptide newly created N terminus HA2. We previously reported that M2 enhances pandemic 2009 A [(H1N1)pdm09] HA-pseudovirus infectivity, but mechanism was...
Traditional microbiological methodology is valuable and essential for microbiota composition description microbe role assignations at different anatomical sites, including cervical vaginal tissues; that, combined with molecular biology strategies modern identification approaches, could give a better perspective of the microbiome under circumstances. This pilot work aimed to describe differences in non-cancer women cancer through culturomics approach combining culture techniques Vitek mass...
Abstract: The last influenza A pandemic provided an excellent opportunity to study the adaptation of A(H1N1)pdm09 virus human host. Particularly, due availability sequences taken from isolates since beginning until date, we could monitor amino acid changes that occurred in hemagglutinin (HA) as spread worldwide and became dominant H1N1 strain. HA is crucial viral infection because it binds sialidated cell-receptors mediates fusion cell membranes; antibodies bind may block entry cell, this...
Hemagglutinin is the major surface glycoprotein of influenza viruses. It participates in initial steps viral infection through receptor binding and membrane fusion events. The pandemic 2009 provided a unique scenario to study virus evolution. We performed molecular dynamics simulations with four hemagglutinin variants that appeared throughout A (H1N1) pandemic. found variant 1 (S143G, S185T) likely arose avoid immune recognition. Variant 2 (A134T), 3 (D222E, P297S) had an increased affinity...
Wastewater serves as a reservoir for antimicrobial-resistant bacteria. This study revealed the presence of carbapenem-resistant and carbapenemase-producing Gram-negative bacilli (GNB), established clonal relationships among isolates in hospital municipal wastewater, identified high-risk clone wastewater. A total 63 GNB were obtained, with Enterobacterales being most frequently isolated group (62%). Carbapenemase-producing Lelliottia amnigena, Kluyvera cryocrescens, Shewanella putrefaciens...
Tuberculosis is a disease caused by Mycobacterium tuberculosis, representing the second leading cause of death an infectious agent worldwide. The available vaccine against this has insufficient coverage and variable efficacy, accounting for high number cases In fact, estimated third world's population latent infection. Therefore, developing new vaccines crucial to preventing it. study, highly antigenic PE_PGRS49 PE_PGRS56 proteins were analyzed. These used predicting T- B-cell epitopes human...