A5009845102- Biochemical and Molecular Research
- Bioactive Compounds and Antitumor Agents
- RNA modifications and cancer
- DNA and Nucleic Acid Chemistry
- Fungal Biology and Applications
- HIV/AIDS drug development and treatment
- Calcium signaling and nucleotide metabolism
- Microbial Natural Products and Biosynthesis
- Amino Acid Enzymes and Metabolism
- Pneumocystis jirovecii pneumonia detection and treatment
- Chemical synthesis and alkaloids
Technische Universität Berlin
2024
Friedrich Schiller University Jena
2022
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2022
This Highlight offers a perspective on recent strategies for synthesising purine nucleoside antibiotics, an untapped source of natural products developing novel antimicrobial agents.
Nucleoside and nucleotide analogues have proven to be transformative in the treatment of viral infections cancer. One branch structural modification deliver new nucleoside analogue classes explores replacement canonical ribose oxygen with a sulfur atom. Whilst biological activity such has been shown some cases, widespread exploration this compound class is hitherto hampered by lack straightforward universal nucleobase diversification strategy. Herein, we present synergistic platform enabling...
(Pre-)anthraquinones are widely distributed natural compounds and occur in plants, fungi, microorganisms, animals, with atrochrysone (1) as the key biosynthetic precursor. Chemical analyses established mushrooms of genus Cortinarius-the webcaps-as producers atrochrysone-derived octaketide pigments. However, more recent genomic data did not provide any evidence for known carboxylic acid (4) synthases nor other polyketide synthase (PKS) producing oligocyclic metabolites. Here, we describe an...
Nucleoside and nucleotide analogues have proven transformative in the treatment of viral infections cancer. One branch structural modification to deliver new nucleoside analogue classes explores replacement canonical ribose oxygen with a sulfur atom. Whilst biological activity such has been shown some cases, widespread exploration this class is hitherto hampered by lack straightforward universal nucleobase diversification strategy. Herein, we present synergistic platform enabling both...
Ribose-1-phosphate (Rib1P) is a key substrate for the synthesis of difficult-to-access nucleoside analogues by phosphorylases. However, its use in preparative hampered low yields and selectivity during preparation conventional methods. Although biocatalysis permits straightforward access to Rib1P directly from natural nucleosides, these transformations are tightly thermodynamically controlled suffer non-trivial work-up procedures. To address challenges, we developed biocatalytic cascade that...
Ribose-1-phosphate (Rib1P) is a key substrate for the synthesis of difficult-to-access nucleoside analogues by phosphorylases. However, its use in preparative hampered low yields and selectivity...
Abstract (Prä‐)Anthrachinone sind weit verbreitete Naturstoffe, die in Pflanzen, Pilzen und Mikroorganismen vorkommen deren biosynthetischer Vorläufer das Atrochryson ( 1 ) ist. Chemische Analysen zeigten, dass Pilze der Gattung Cortinarius – Schleierlinge Produzenten von Octaketid‐Farbstoffen sind, sich ableiten. Neuere genomische Daten lieferten jedoch keine Hinweise auf bekannte Atrochrysonsäure 4 )‐Synthasen oder andere Polyketidsynthasen (PKSs), oligocyclische Metabolite produzieren....
Abstract Nucleoside and nucleotide analogues have proven to be transformative in the treatment of viral infections cancer. One branch structural modification deliver new nucleoside analogue classes explores replacement canonical ribose oxygen with a sulfur atom. Whilst biological activity such has been shown some cases, widespread exploration this compound class is hitherto hampered by lack straightforward universal nucleobase diversification strategy. Herein, we present synergistic platform...