A5064483920- Forensic Anthropology and Bioarchaeology Studies
- Advanced Glycation End Products research
- Occupational and environmental lung diseases
- Paleopathology and ancient diseases
- Biomarkers in Disease Mechanisms
- dental development and anomalies
- Pleistocene-Era Hominins and Archaeology
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- S100 Proteins and Annexins
- Drug-Induced Hepatotoxicity and Protection
- Heme Oxygenase-1 and Carbon Monoxide
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Air Quality and Health Impacts
- Adenosine and Purinergic Signaling
- Dental Trauma and Treatments
- Forensic and Genetic Research
- Congenital Anomalies and Fetal Surgery
- Archaeology and Historical Studies
- Archaeology and ancient environmental studies
- Inflammatory mediators and NSAID effects
- Bone and Dental Protein Studies
- Tattoo and Body Piercing Complications
- Esophageal Cancer Research and Treatment
- Chronic Kidney Disease and Diabetes
British Museum
2014-2025
Tamil Nadu Veterinary and Animal Sciences University
2021
University of Liverpool
2009-2020
Medical Research Council
2012-2020
Bicêtre Hospital
2018
University College London
2002-2016
Drug Safety Research Unit
2016
CHU Dijon Bourgogne
2011-2015
Laboratoire d'étude de l'apprentissage et du développement
2014
Yale University
2014
Currently, no blood biomarker that specifically indicates injury to the proximal tubule of kidney has been identified. Kidney molecule-1 (KIM-1) is highly upregulated in tubular cells following injury. The ectodomain KIM-1 shed into lumen, and serves as a urinary We report also Sensitive assays measure plasma serum mice, rats, humans were developed validated current study. Plasma levels increased with increasing periods ischemia (10, 20, or 30 minutes) early 3 hours after reperfusion;...
Abstract Dental tissues contain regular microscopic structures believed to result from periodic variations in the secretion of matrix by enamel‐ and dentine‐forming cells. Counts these are an important tool for reconstructing chronology dental development both modern fossil hominids. Most studies rely on periodicity cross‐banding that occurs along long axis enamel prisms. These prism cross‐striations widely thought reflect a circadian rhythm generally regarded as representing daily...
Liver fibrosis is associated with significant collagen-I deposition largely produced by activated hepatic stellate cells (HSCs); yet, the link between hepatocyte damage and HSC profibrogenic response remains unclear. Here we show induction of osteopontin (OPN) high-mobility group box-1 (HMGB1) in liver fibrosis. Since OPN was identified as upstream HMGB1, hypothesised that could participate pathogenesis increasing HMGB1 to upregulate expression.Patients long-term hepatitis C virus (HCV)...
High mobility group box 1 (HMGB1) is a central mediator in inflammation and immunity. Recently, it was shown that different redox states of the three cysteines HMGB1 endow with mutually exclusive activities, such as inducing chemotaxis or transcription cytokines chemokines, via interaction receptors. The forms can be identified by mass spectrometry body fluids patients may hold promise biomarkers. We propose here systematic nomenclature related proteins, to replace conflicting names used so...
Abstract Purpose: To determine whether serum levels of high mobility group box protein 1 (HMGB1) could differentiate malignant mesothelioma patients, asbestos-exposed individuals, and unexposed controls. Experimental Design: Hyperacetylated nonacetylated HMGB1 (together referred to as total HMGB1) were blindly measured in blood collected from patients (n = 22), individuals with verified chronic asbestos exposure 20), benign pleural effusions 13) or not due 25), healthy controls 20). Blood...
Cancer, one of the world's leading causes death today, remains almost absent relative to other pathological conditions, in archaeological record, giving rise conclusion that disease is mainly a product modern living and increased longevity. This paper presents male, young-adult individual from site Amara West northern Sudan (c. 1200BC) displaying multiple, osteolytic, lesions on vertebrae, ribs, sternum, clavicles, scapulae, pelvis, humeral femoral heads. Following radiographic, microscopic...
Abstract The remains of 61 individuals buried in the cemetery Jebel Sahaba (site 117) offer unique and substantial evidence to emergence violence Nile Valley at end Late Pleistocene. Excavated assessed 1960s, some original findings interpretations are disputed. A full reanalysis timing, nature extent was conducted through microscopic characterization each osseous lesion, reassessment archaeological data. Over 100 previously undocumented healed unhealed lesions were identified on both new...
Hepatic ischemia/reperfusion (IRP) injury is a significant clinical problem during tumor-resection surgery (Pringle maneuver) and liver transplantation. However, the relative contribution of necrotic apoptotic cell death to overall still controversial. To address this important issue with standard murine model hepatic IRP injury, plasma biomarkers such as micro-RNA 122, full-length cytokeratin 18 (FK18), high-mobility group box 1 (HMGB1) protein apoptosis caspase-3 activity caspase-cleaved...
The aim of this study was to establish reference intervals in healthy children for two novel urinary biomarkers acute kidney injury, injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Urinary were determined samples from the UK (n = 120) USA 171) using both Meso Scale Discovery (MSD) Luminex-based analytical approaches. 95% each biomarker cohort are presented stratified by sex or ethnicity where necessary, age-related variability is explored quantile regression....
<b>Background:</b> Previous studies have estimated the prevalence of tuberculosis and HIV infection in population subgroups UK. This study was undertaken to describe recent trends proportion individuals with among reported cases England Wales, review implications for clinical public health care. <b>Methods:</b> A population-based matching using national surveillance databases used investigate all persons aged 15 years over a diagnosis Health Protection Agency Wales 1999–2003. Record linkage...
Sterile liver inflammation, such as ischemia-reperfusion, hemorrhagic shock after trauma, and drug-induced injury, is initiated regulated by endogenous mediators including DNA reactive oxygen species. Here, we identify a mechanism for redox-mediated regulation of absent in melanoma 2 (AIM2) inflammasome activation hepatocytes redox stress mice, which occurs through interaction with cytosolic high mobility group box 1 (HMGB1). We show that during mice hypoxia reoxygenation, HMGB1 associates...
Mouse embryonic stem cells (mESCs) undergo self-renewal in the presence of cytokine, leukaemia inhibitory factor (LIF). Following LIF withdrawal, mESCs differentiate, and this is accompanied by an increase cell-substratum adhesion cell spreading. The purpose study was to investigate relationship between spreading mESC differentiation. Using E14 R1 lines, we have restricted absence either culturing on chemically defined, weakly adhesive biomaterial substrates, or manipulating cytoskeleton. We...
A full-body virtual autopsy of an ancient Egyptian mummy showed visitors he was likely murdered.
Inflammatory periosteal reaction (IPR) on the visceral surfaces of ribs has been used in bioarchaeology as an indicator lower respiratory tract disease. This article presents a detailed method for recording IPR ribs, even those severely fragmented states, with objectives increasing consistency and producing true prevalence rates skeletons so to improve data comparability between future bioarchaeological studies disease.The presence respiratory-related were recorded from three different...
Transitions from foraging to food-production represent a worldwide turning point in recent human history. In the Middle Nile Valley this cultural shift occurred between sixth and beginning of fifth millennium BCE. Significant craniodental morphological differences remain inadequately tested by biometric analyses ancestry may reflect population origins or diet change last hunter-fisher-gatherers (Mesolithic) first food-producers (Neolithic). Moreover, with no ancient DNA data for region very...
This study presents biological affinities between the last hunter-fisher-gatherers and first food-producing societies from Nile Valley. We investigate odontometric dental tissue proportion changes these populations Middle Valley acknowledge processes behind them.