A5043564103- Photoacoustic and Ultrasonic Imaging
- Photodynamic Therapy Research Studies
- Advancements in Transdermal Drug Delivery
- Bee Products Chemical Analysis
- Porphyrin and Phthalocyanine Chemistry
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nanoplatforms for cancer theranostics
- Laser Material Processing Techniques
- Photosynthetic Processes and Mechanisms
- Microbial Inactivation Methods
- Thermography and Photoacoustic Techniques
- Photoreceptor and optogenetics research
- Hemoglobin structure and function
- Heme Oxygenase-1 and Carbon Monoxide
- Dermatologic Treatments and Research
LaserLeap Technologies (Portugal)
2013-2017
University of Coimbra
2008-2012
Photoacoustic (PA) waves generated by short laser pulses absorbed piezophotonic materials are shown to permeabilize the stratum corneum large molecules and proteins. Two minutes of such PA at a pulse frequency 20 Hz increase transepidermal water loss (TEWL) healthy human skin factor 2.5, relaxes normal two later. The intraepidermal delivery Green Fluorescence Protein (GFP) in minipigs with this method does not lead observable adverse effects. distinctive features high light-to-pressure...
Photodynamic therapy (PDT) is a promising treatment for several types of cancers. It involves the synergetic effect light, oxygen and an appropriate photosensitizer. Extensive studies on synthetic modulation structure tetrapyrrolic macrocycles allowed optimization chemical physical properties such photosensitizers. The progress from porphyrins to chlorins more recently bacteriochlorins clearly shows improvements achieved in PDT This paper summarizes our recent contribution synthesis stable...
Manganese(III) and manganese(II) complexes of halogenated sulfonamide tetraphenylbacteriochlorins were prepared for the first time via a transmetalation reaction shown to be stable at room temperature. The behavior electronic states paramagnetic is remarkably different from those metal-free bacteriochlorins or diamagnetic metallobacteriochlorins. Mn3+ complex exhibits eight transitions between 300 1100 nm, with very prominent band (molar absorption coefficient ca. 50000 M–1 cm–1) 829 nm....
Pressure waves generated by laser pulses can permeabilize biological barriers, such as the skin or cellular membranes. The characteristics of absorbing materials are decisive in determining shape and amplitude pressure impulse transients. Based on physics photochemistry light-to-pressure conversion, we generate high intensity broadband ultrasound capable transiently permeabilizing barriers. We show evidence that no damage is done to cells exposed recovers its protective function some minutes...
A skin depth map was built reconstructing photoacoustic signals at several wavelengths of visible and infrared light. The mapping technique used to follow the diffusion through near-infrared absorbing dyes. Such dyes can be useful for photodynamic therapy (PDT) lesions are investigated as contrast agents tomography (PAT), because they strongly absorb light where is more transparent.
The aim of this work is to improve the understanding interaction between photoacoustic waves and skin. We employ with 1 MPa amplitude center frequencies 100 MHz transiently perturb model lipid membranes stratum corneum mini pigs. structure transient perturbation observed tentatively attributed a temperature rise mechanism. also try show that dynamic acoustic radiation force mechanism can explain induced by in Indeed, 15 bar pressure gradients across 5 corneocytes (approx. μm wide) are shown...
A skin depth map was built reconstructing photoacoustic signals at several wavelengths of visible and infrared light. The mapping technique used to follow the diffusion through near-infrared absorbing dyes. Such dyes can be useful for photodynamic therapy (PDT) lesions are investigated as contrast agents tomography (PAT), because they strongly absorb light where is more transparent.