A5023058239- Kruppel-like factors research
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
- FOXO transcription factor regulation
- Virus-based gene therapy research
- Cell Adhesion Molecules Research
- Chronic Myeloid Leukemia Treatments
- Genomics and Chromatin Dynamics
- Pluripotent Stem Cells Research
Wannan Medical College
2022
First Affiliated Hospital of Wannan Medical College
2022
Abstract Our previous study illustrated that nuclear factor IX (NFIX) promotes glioblastoma (GBM) progression by inducing migration and proliferation of GBM cells. However, the underlying mechanism how NFIX regulates cell remains obscure. In this study, we uncovered Go-Ichi-Ni-San 1 (GINS1) is upregulated positively correlated with in human specimen. silencing downregulates expression GINS1, which pivotal for cell-cycle Replenishment GINS1 largely rescues NFIX-null effect on proliferation....
<p>S1. Full images of immunoblotting. S2. NFIX knockdown has no effect on p53 and p21 expression. S3. Knockdown GINS1 by shRNAs in U87 cells. S4. represses proliferation GL261 cells S5. rescues the delayed growth NFIX-null tumor. S6. directly up-regulated gene occupying its promoter</p>
<p>S1. Full images of immunoblotting. S2. NFIX knockdown has no effect on p53 and p21 expression. S3. Knockdown GINS1 by shRNAs in U87 cells. S4. represses proliferation GL261 cells S5. rescues the delayed growth NFIX-null tumor. S6. directly up-regulated gene occupying its promoter</p>
<div>Abstract<p>Our previous study illustrated that nuclear factor IX (NFIX) promotes glioblastoma (GBM) progression by inducing migration and proliferation of GBM cells. However, the underlying mechanism how NFIX regulates cell remains obscure. In this study, we uncovered Go-Ichi-Ni-San 1 (GINS1) is upregulated positively correlated with in human specimen. silencing downregulates expression GINS1, which pivotal for cell-cycle Replenishment GINS1 largely rescues NFIX-null effect...
<div>Abstract<p>Our previous study illustrated that nuclear factor IX (NFIX) promotes glioblastoma (GBM) progression by inducing migration and proliferation of GBM cells. However, the underlying mechanism how NFIX regulates cell remains obscure. In this study, we uncovered Go-Ichi-Ni-San 1 (GINS1) is upregulated positively correlated with in human specimen. silencing downregulates expression GINS1, which pivotal for cell-cycle Replenishment GINS1 largely rescues NFIX-null effect...