Michael Nugent

ORCID: 0000-0002-7469-4389
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About
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Research Areas
  • Hydrogels: synthesis, properties, applications
  • Bone Tissue Engineering Materials
  • Electrospun Nanofibers in Biomedical Applications
  • biodegradable polymer synthesis and properties
  • Anesthesia and Sedative Agents
  • Nanoparticle-Based Drug Delivery
  • 3D Printing in Biomedical Research
  • Titanium Alloys Microstructure and Properties
  • Advanced Polymer Synthesis and Characterization
  • Advanced Cellulose Research Studies
  • Anesthesia and Neurotoxicity Research
  • Graphene and Nanomaterials Applications
  • Electrohydrodynamics and Fluid Dynamics
  • Microfluidic and Capillary Electrophoresis Applications
  • Cardiac, Anesthesia and Surgical Outcomes
  • Cardiac Imaging and Diagnostics
  • Cardiac Ischemia and Reperfusion
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Nitric Oxide and Endothelin Effects
  • Advanced Drug Delivery Systems
  • RNA Interference and Gene Delivery
  • Non-Destructive Testing Techniques
  • Metal and Thin Film Mechanics
  • Wound Healing and Treatments
  • Advanced Materials and Mechanics

Athlone Institute of Technology
2015-2024

Aboriginal Health Council of South Australia
2024

Sunderland Royal Hospital
2024

Technological University of the Shannon: Midlands Midwest
2022-2024

Johns Hopkins Medicine
2024

Johns Hopkins University
2024

Ngaanyatjarra Health Service
2021-2022

Shaker Heights Public Library
2016-2019

The University of Texas at Austin
2014

Linde (United States)
1998-1999

The effects of midazolam maleate and diazepam on cerebral metabolism circulation were examined for each drug in six dogs maintained N2O 70 per cent halothane less than 0.1 cent. Midazolam at 0.2 mg/kg 0.3 (the ED 100 induction anesthesia humans) did not decrease metabolic rate oxygen (CMRO2) but blood flow (CBF) to about 55 control. Additional administrations (2.0, 5.0, 10.0 maleate, 3.0 7.5 diazepam) resulted dose-related decreases CMRO2 a maximum control after maleate. Concomitant with the...

10.1097/00000542-198203000-00003 article EN Anesthesiology 1982-03-01

Microfibrillated cellulose as a reinforcement agent has been investigated extensively due to their unique characteristics, which can reorder the structure of polymers and hydrogels leading improved mechanical properties with minimal disadvantages in terms targeted original applications. However, effect using macro- micro-fibrillated onto polyvinyl alcohol is still unknown, because ability for both be produced from freeze-thawing mechanisms – hydrogen bonding - there potential synergism....

10.1016/j.carbpol.2020.116612 article EN publisher-specific-oa Carbohydrate Polymers 2020-06-11

Wound infections are the main complication when treating skin wounds. This work reports a novel antimicrobial material using green synthesized zinc oxide nanoparticles (ZnONPs) incorporated in polymeric fibers for wound healing purposes. ZnONPs promising nanomaterial with high activity against range of microorganisms, including drug-resistant bacteria. The electrospun were obtained polyacrylic acid (PAA) and polyallylamine hydrochloride (PAH) loaded from Ilex paraguariensis leaves spherical...

10.3390/ma14112889 article EN Materials 2021-05-27

10.1016/j.jmbbm.2008.12.003 article EN Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials 2008-12-16

The effectiveness of tannic acid as antimicrobial and wound healing for burns have been shown a century; however, uncontrolled target dosage may result in undesirable side-effects. Remarkably, polyphenols compounds crosslinked with polymeric materials produce strong composite containing the beneficial properties this tannin. However, investigation crosslink structure its antibacterial regenerative are still unknown when using nanocellulose by mechanical defibrillation; additionally, due to...

10.1007/s10856-021-06536-4 article EN cc-by Journal of Materials Science Materials in Medicine 2021-06-01

The authors sought to determine if isoflurane would attenuate effects of three different types vasoconstrictors on isolated segments canine epicardial coronary arteries removed from healthy dogs. As the endothelium has a major role in regulating artery tone, and as it modulates effect many vasoactive substances, experiments were conducted both normal rings whose had been mechanically removed. In addition, is thought be damaged human atherosclerosis. Rings suspected organ chambers filled with...

10.1097/00000542-198710000-00012 article EN Anesthesiology 1987-10-01

To determine the site of isoflurane-associated coronary vasodilatation, authors measured epicardial artery diameter and examined effects isoflurane on arteriolar tone. Angiograms left system were obtained in seven fentanyl-pentobarbital anesthetized dogs quantitated with a computerized analysis system. Cross-sectional areas proximal, mid, distal anterior descending proximal circumflex arteries at three arterial pressures, then measurement repeated following administration 0.75%, 1.5%, 2.25%...

10.1097/00000542-198703000-00003 article EN Anesthesiology 1987-03-01

Innovations on the field of smart hydrogels are now being held with loads advantages. With recent progress, polymers can be used market for specific target/objectives desired medicine. However, has not been fully overviewed ground drug delivery. In this study, a novel pH‐sensitive hydrogel delivery was investigated. Polyvinyl‐alcohol (PVA) polyacrylic acid (PAA) blended adding synthetic hydroxyapatite (Hap) freeze‐thawed cycles and its effects were studied in terms mechanical strength,...

10.1002/pat.3593 article EN Polymers for Advanced Technologies 2015-07-14

Messick, Joseph M. JR, MD; Newberg, Leslie A. Nugent, Michael Faust, Ronald J. MD Author Information

10.1213/00000539-198502000-00008 article EN Anesthesia & Analgesia 1985-02-01

Microfibrillated cellulose films have been gathering considerable attention due to their high mechanical properties and cheap cost. Additionally, it is possible include compounds within the fibrillated structure in order confer desirable properties. Ilex paraguariensis A. St.-Hil, yerba mate leaf extract has reported possess a quantity of caffeoylquinic acids that may be beneficial for other applications instead its conventional use as hot beverage. Therefore, we investigate effect blending...

10.3390/polym12122807 article EN Polymers 2020-11-27

Polyvinyl alcohol/polyacrylic acid (PVA/PAA) bilayer hydrogel nanofibres were successfully fabricated by electrospinning and physically crosslinked via heat treatment. The effects of the thermal annealing process on structure, morphology, swelling, properties hydrophilicity electrospun investigated. In addition, these membranes also used to incorporate doxorubicin clarithromycin for osteosarcoma treatment, one in each layer. These drugs because it is hypothesized this work that a synergism...

10.1016/j.mtchem.2021.100549 article EN cc-by Materials Today Chemistry 2021-08-27
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