A5034056465- Ocular Surface and Contact Lens
- Contact Dermatitis and Allergies
- melanin and skin pigmentation
- Allergic Rhinitis and Sensitization
- Olfactory and Sensory Function Studies
Friedrich-Alexander-Universität Erlangen-Nürnberg
2022-2024
Meibomian gland dysfunction (MGD) is one of the main causes dry eye disease. To better understand physiological functions human meibomian glands (MGs), present study compared MGs with free sebaceous (SGs) and hair-associated SGs humans using morphological, immunohistochemical, liquid chromatography—mass spectrometry (LCMS)-based lipidomic approaches. Eyelids MGs, nostrils, lips, external auditory canals SGs, scalp body donors were probed antibodies against cytokeratins (CK) 1, 8, 10, 14,...
The meibomian glands (MGs) within the eyelids produce a lipid-rich secretion that forms superficial layer of tear film. Meibomian gland dysfunction (MGD) results in excessive evaporation film, which is leading cause dry eye disease (DED). To develop research model similar to physiological situation MGs, we established new 3D organotypic slice culture (OSC) mouse MGs (mMGs) and investigated effects melanocortins on exocrine secretion. Tissue viability, lipid production morphological changes...