A5019111660- Neurobiology and Insect Physiology Research
- Cellular Mechanics and Interactions
- Cancer Treatment and Pharmacology
- Axon Guidance and Neuronal Signaling
- Retinal Development and Disorders
- Cellular transport and secretion
- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Physiological and biochemical adaptations
- Circadian rhythm and melatonin
- Multiple Myeloma Research and Treatments
- Pain Mechanisms and Treatments
Columbia University
2019-2023
Howard Hughes Medical Institute
2013
Columbia University Irving Medical Center
2013
Neuronal communication depends on the precisely orchestrated release of neurotransmitter at specialized sites called active zones (AZs). A small number scaffolding and cytoskeletal proteins comprising cytomatrix zone (CAZ) are thought to organize architecture functional properties AZs. The majority CAZ evolutionarily conserved, underscoring fundamental similarities in neurotransmission all synapses. However, core Piccolo Bassoon have long been believed exclusive vertebrates, raising...
Significance Paclitaxel is a common chemotherapeutic agent and often causes form of sensory dysfunction termed chemotherapy-induced peripheral neuropathy (CIPN). There no approved therapy to counteract CIPN, although the CIPN symptoms interfere with effective cancer treatment impose long-term health economic burdens for survivors. As chemotherapy still first-line many patients, understanding basis critical. Using complementary approaches in Drosophila mouse neurons, we characterized...
Left/right asymmetric features of animals are either randomly distributed on the left or right side within a population (“antisymmetries”) found stereotypically one particular an animal (“directional asymmetries”). Both types asymmetries can be in nervous systems, but whether regulatory programs that establish these share any mechanistic is not known. We describe here unprecedented molecular link between two Caenorhabditis elegans . The zinc finger transcription factor die-1 expressed...
ABSTRACT Synaptic connections between neurons are often formed in precise subcellular regions of dendritic arbors with implications for information processing within neurons. Cell–cell interactions widely important circuit wiring; however, their role specificity is not well understood. We studied the axon–axon targeting and wiring Drosophila somatosensory circuitry. Axons nociceptive gentle touch terminate adjacent, non-overlapping layers central nervous system (CNS). Nociceptor receptor...
Abstract Axon and dendrite placement connectivity is guided by a wide range of secreted surface molecules in the developing nervous system. Nevertheless, extraordinary complexity connections brain requires that this repertoire be further diversified to precisely uniquely regulate cell-cell interactions. One important mechanism for molecular diversification alternative splicing. Drosophila Down syndrome cell adhesion molecule (Dscam2 ) undergoes type-specific splicing produce two...
Summary Chemotherapy induced peripheral neuropathy (CIPN) is a major side effect from cancer treatment with no known method for prevention or cure in clinics. CIPN primarily affects unmyelinated nociceptive sensory terminals. Despite the high prevalence of CIPN, molecular and cellular mechanisms that lead to are still poorly understood. Here, we used genetically tractable Drosophila model primary neurons isolated adult mouse examine underlying identify protective pathways. We found chronic...