A5101889648- Lipid Membrane Structure and Behavior
- Mechanical and Optical Resonators
- Microfluidic and Bio-sensing Technologies
- Proteins in Food Systems
- Metabolism and Genetic Disorders
- Protein Hydrolysis and Bioactive Peptides
- Mitochondrial Function and Pathology
- Microfluidic and Capillary Electrophoresis Applications
- Microbial Inactivation Methods
- Cancer, Hypoxia, and Metabolism
- Nanopore and Nanochannel Transport Studies
Hôpital Pellegrin
2024
Centre Hospitalier Universitaire de Bordeaux
2024
Delft University of Technology
2015-2019
Cell lipid membranes are the site of vital biological processes, such as motility, trafficking, and sensing, many which involve mechanical forces. Elucidating interplay between bioprocesses forces requires use tools that apply measure piconewton-level forces, e.g., optical tweezers. Here, we introduce combination tweezers with free-standing bilayers, fully accessible on both sides membrane. In vicinity bilayer, trapping would normally be impossible due to distortions caused by pockets...
We report a simple, cost-effective, and reproducible method to form free-standing lipid bilayer membranes in microdevices made with Norland Optical Adhesive 81 (NOA81). Surface treatment either alkylsilane or fluoroalkylsilane enables the self-assembly of stable 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC) membranes. Capacitance measurements are used characterize follow its formation...
Nonketotic hyperglycinemia (NKH) is a rare, autosomal recessive metabolic disorder usually associated with mutations in genes