A5054372400- Phytochemicals and Antioxidant Activities
- Protein Hydrolysis and Bioactive Peptides
- Edible Oils Quality and Analysis
- Essential Oils and Antimicrobial Activity
- Biochemical effects in animals
- Landslides and related hazards
- Antimicrobial Peptides and Activities
- Metabolomics and Mass Spectrometry Studies
- Pomegranate: compositions and health benefits
- Neuroscience and Neuropharmacology Research
- Advanced Photocatalysis Techniques
- Chromatography in Natural Products
- Analytical Chemistry and Chromatography
- Bioactive Compounds in Plants
- Multiple Myeloma Research and Treatments
- Probiotics and Fermented Foods
- Ion Channels and Receptors
- Food composition and properties
- Fermentation and Sensory Analysis
- Phytochemistry and Biological Activities
- Eicosanoids and Hypertension Pharmacology
- Proteins in Food Systems
- Hormonal Regulation and Hypertension
- Hops Chemistry and Applications
- Ion channel regulation and function
University of Salerno
2016-2025
University of Palermo
2024-2025
University of Genoa
2018-2023
Villa Pineta Hospital
2017-2018
University of Reggio Calabria
2016-2017
Grain sorghum (Sorghum bicolor) is a gluten-free cereal grown around the world and food staple in semi-arid subtropical regions. Sorghum diverse crop with range of pericarp colour including white, various shades red, black, all which show health-promoting properties as they are rich sources antioxidants such polyphenols, carotenoids, well micro- macro-nutrients. This work examined grain composition three varieties possessing colours (white, black) Mediterranean region. To determine...
Lycium barbarum, known as goji berry or wolfberry, is a fruit long associated with health benefits, showing plethora of effects ranging from antioxidant, anticancer, anti-inflammatory, and immunomodulatory effects. Its potential attributed to the significant presence polysaccharides, glycopeptides, polyphenols, flavonoids, carotenoids, their derivatives. These compounds effectively counteract action free radicals, positively influencing cellular balance intracellular signaling, contributing...
In this paper we present the design, synthesis, and biological evaluation of a new series peptidomimetics acting as potent anti-SARS-CoV-2 agents. Starting from our previously described Main Protease (M
Bovine milk possesses a protein system constituted by two major families of proteins: caseins (insoluble) and whey proteins (soluble). Caseins ( α S1 , S2 β κ ) are the predominant phosphoproteins in ruminants, accounting for about 80% total protein, while proteins, representing approximately 20% fraction, include -lactoglobulin, -lactalbumin, immunoglobulins, bovine serum albumin, lactoferrin, lactoperoxidase, together with other minor components. Different bioactivities have been...
Inflammation and oxidative stress are always more recognized as responsible for chronic disease at the intestinal level. Currently, a growing interest is addressed to discovery of diet-derived products which have anti-inflammatory antioxidant properties. This work aims characterize pharmacological potential dehydrated potatoes. For this purpose, simulated gastrointestinal digestion was carried out. The bioaccessible peptides were fractionated on basis their molecular weight tested epithelial...
Many studies have explored the extraction of bioactive compounds from different onion solid wastes, such as bulb, skin, and peel. However, leaves received limited attention despite their potential a valuable source nutraceutical compounds. This study aimed to valorise, for first time, agricultural waste in form spring (CN, Cipollotto Nocerino) obtain antioxidant-rich polyphenolic extracts. A Box-Behnken design (BBD) was used assess impact microwave-assisted (MAE) variables (temperature,...
Extracellular vesicles (EVs) are promising tools for nanomedicine and nanobiotechnology. The purification of mammalian-derived EVs involves intensive processes, their therapeutic application raises multiple safety regulatory issues. Plants have the potential to serve as nonconventional sources therapeutically relevant EVs. In this context, we recently identified hairy roots (HRs) medicinal plants a novel biotechnological platform produce human health.
Gain-of-function (GoF) variants in KCNT1 channels cause severe, drug-resistant forms of epilepsy. Quinidine is a known blocker, but its clinical use limited due to severe drawbacks. To identify novel blockers, homology model human was built and used screen an in-house library compounds. Among the 20 molecules selected, five (
Lycium barbarum, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also an important source of bioactive compounds such polysaccharides, carotenoids, phenolics, various other non-nutritive compounds. These constituents give it a multitude health benefits, including antioxidant, anti-inflammatory, anticancer properties. However, the precise biochemical mechanisms responsible effects remain unclear, comprehensive...
Arthrospira platensis, better known as Spirulina, is one of the most important microalgae species. This cyanobacterium possesses a rich metabolite pattern, including high amounts natural pigments. In this study, we applied combined strategy based on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS) and Ultra High-Performance Liquid Chromatography (UHPLC) for qualitative/quantitative characterization Spirulina pigments in three different commercial dietary supplements....
Redox signaling regulates different gastrointestinal (G.I.) epithelium functions. At the intestinal level, loss of redox homeostasis in epithelial cells (IECs) is responsible for pathogenesis and development a wide diversity G.I. disorders. Thus, manipulation oxidative stress IECs could represent an important pharmacological target diseases. In this study, peptides released from vitro gastro digestion buffalo-milk commercial dairy products were identified evaluated their bioactive...
Since the discovery of compound BIX01294 over 10 years ago, only a very limited number nonquinazoline inhibitors H3K9-specific methyltransferases G9a and G9a-like protein (GLP) have been reported. Herein, we report identification novel chemotype for G9a/GLP inhibitors, based on underinvestigated 2-alkyl-5-amino- 2-aryl-5-amino-substituted 3H-benzo[e][1,4]diazepine scaffold. Our research efforts resulted in 12a (EML741), which not maintained high vitro cellular potency its quinazoline...
Colorectal cancer (CRC) mortality is mainly caused by patient refractoriness to common anti-cancer therapies and consequent metastasis formation. Besides, the notorious toxic side effects of chemotherapy are a concurrent obstacle be tackled. Thus, new treatment approaches needed effectively improve outcomes. Compelling evidence demonstrated that stem cells (CSCs) responsible for failure relapse. New natural showed capabilities selectively target CSC subpopulation rendering them targetable...
5-Fluorouracil (5-FU) is a pyrimidine analogue used as an antineoplastic agent to treat multiple solid tumors. Despite its use and efficacy, it also has important side effects in healthy cells, including skin reactions, related pro-oxidant pro-inflammatory potential. Although there are numerous remedies for chemotherapy-induced the efficacy of these treatments remains limited. In this study we focused on pomegranate (Punica granatum L.) juice extract (PPJE) oxidative inflammatory state...
Neuronal Kv7 channels represent important pharmacological targets for hyperexcitability disorders including epilepsy. Retigabine is the prototype activator clinically approved seizure treatment; however, severe side effects associated with long-term use have led to its market discontinuation. Building upon recently described cryoEM structure of Kv7.2 complexed retigabine and on previous structure–activity relationship studies, a small library analogues has been designed, synthesized,...
A research platform for food authentication was set up by combining stable isotope ratio analysis, metabolomics gas and liquid mass-spectrometry NMR investigations, chemometric analyses excellences. This multi-analytical approach tested on samples of elephant garlic (Allium ampeloprasum L.), a species belonging to the same genus common sativum mainly produced in southern Tuscany-(TA). The isotopic composition allowed product be geographically characterized. Flavonoids, like (+)-catechin,...