A5052484889- Acute Myeloid Leukemia Research
- Genomics and Chromatin Dynamics
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- DNA Repair Mechanisms
- DNA and Nucleic Acid Chemistry
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- RNA and protein synthesis mechanisms
- Genetic factors in colorectal cancer
- Glycosylation and Glycoproteins Research
- Genomic variations and chromosomal abnormalities
- Immunodeficiency and Autoimmune Disorders
- Glutathione Transferases and Polymorphisms
- RNA modifications and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chromosomal and Genetic Variations
- Childhood Cancer Survivors' Quality of Life
- Lipoproteins and Cardiovascular Health
- BRCA gene mutations in cancer
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- Hemoglobinopathies and Related Disorders
- Parasitic infections in humans and animals
Newcastle University
2014-2025
University of Stirling
2024
University of Edinburgh
2006-2021
Western General Hospital
2001-2021
Clinical Research Institute
2021
University of Newcastle Australia
2021
Prince of Wales Hospital
2020
Institute of Genetics and Cancer
2017-2019
University of Chicago
2010-2019
Papua New Guinea Institute of Medical Research
2015
We show here that the solenoid is maintained by combination of linker histones and nonglobular, highly basic "tails" core histones, which play only a minor part in formation nucleosome (Whitlock Simpson, 1977. J. Biol. Chem. 252:6,516--6,520; Lilley Tatchell, Nucleic Acids Res. 4:2,039--2,055; Whitlock Stein, 1978. 253:3,857--3,861). Polynucleosomes contain devoid tails remain substantially unfolded under conditions otherwise favorable for solenoids. The can be replaced extraneous...
Glutathione S -transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some which are suspected human carcinogens. Functional polymorphisms exist in at least three genes that encode GSTs, GSTM1, GSTT1, GSTP1. We hypothesize, therefore, GSTs alter susceptibility to chemotherapy-induced carcinogenesis, specifically therapy-related acute myeloid leukemia (t-AML), a devastating complication long-term...
3-methyladenine (3MeA) DNA glycosylases remove 3MeAs from alkylated to initiate the base excision repair pathway. Here we report generation of mice deficient in 3MeA glycosylase encoded by Aag ( Mpg ) gene. Alkyladenine turns out be major not only for cytotoxic lesion, but also mutagenic 1, N 6 -ethenoadenine (ɛA) and hypoxanthine lesions. appears liver, testes, kidney, lung, ɛA kidney; another may expressed lung. Although alkyladenine has capacity 8-oxoguanine lesions, it does appear...
A comprehensive study was undertaken in a rural community the state of Morelos, Mexico to evaluate health education as an intervention measure against Taenia solium. An educational program developed promote recognition and knowledge transmission parasite improve hygienic behavior sanitary conditions that foster transmission. The effects were evaluated by measuring changes practices prevalence human taeniasis swine cysticercosis before after campaign. strategy implemented with active...
Chicken erythrocyte chromatins containing a single species of linker histone, H1 or H5, have been prepared, using reassembly techniques developed previously. The reconstituted complexes possess the conformation native chicken chromatin, as judged by chemical and structural criteria; saturation is reached when two molecules histone are bound per nucleosome, in which resulting material resembles its appearance electron microscope quantitatively linear condensation factor relative to free DNA....