A5014346426- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Nutritional Studies and Diet
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Advanced Chemical Sensor Technologies
- Tryptophan and brain disorders
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Identification and Quantification in Food
- Advanced Proteomics Techniques and Applications
- Phytochemicals and Antioxidant Activities
- Analytical Chemistry and Chromatography
- Spectroscopy and Chemometric Analyses
- Dietary Effects on Health
- Biochemical Analysis and Sensing Techniques
- Mass Spectrometry Techniques and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Computational Drug Discovery Methods
- Isotope Analysis in Ecology
- Metabolism and Genetic Disorders
- Fermentation and Sensory Analysis
- Mitochondrial Function and Pathology
- Heavy metals in environment
- Nutrition and Health in Aging
Universidad de Cádiz
2022-2024
Hospital Universitario Puerta del Mar
2022-2024
Biomedical Research and Innovation Institute of Cadiz
2022-2024
Universitat de Barcelona
2018-2024
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2018-2024
Instituto de Salud Carlos III
2018-2024
Universidad de Huelva
2014-2023
Institute of Agrifood Research and Technology
2020-2022
Centro Nacional de Microbiologia
2022
Universidad de Sevilla
2021
The food industry demands novel green solvents for the extraction of bioactive compounds, particularly from residues agrifood industry. Herein, an ultrasound-assisted method has been developed environmentally friendly phenolic compounds blueberry leaves using natural deep eutectic (NADES). After screening multiple NADES, best efficiencies in terms total phenol content and antioxidant activity were provided by NADES composed lactate, sodium acetate, water (3:1:2), choline chloride oxalic acid...
There is high interest in the discovery of early diagnostic biomarkers Alzheimer's disease, for which metabolomics exhibits a great potential. In this work, metabolomic approach based on ultrafiltration and analysis by CE‐MS has been used to obtain representative fingerprints polar metabolites from serum samples order distinguish between patients with mild cognitive impairment, healthy controls. By use partial least squares discriminant it was possible classify according disease stage then...
Metal dyshomeostasis is closely related to Alzheimer's disease, so the characterization of metal profiles in these patients special interest for studying associated neurodegenerative processes and discover potential markers disease. An analytical approach, based on non-denaturing precipitation proteins, has been optimized fractionation high molecular mass (HMM) low (LMM) metal-species from serum, which were subjected multielemental analysis by inductively coupled plasma spectrometry...
The exposome, defined as the cumulative measure of external exposures and associated biological responses throughout lifespan, has emerged in recent years a cornerstone biomedical sciences. Metabolomics stands out here one most powerful tools for investigating interplay between genetic background, exogenous, endogenous factors within human health. However, to address complexity novel methods are needed characterize metabolome. In this work, we have optimized validated multianalyte...
Fatty acids play prominent roles in brain function as they participate structural, metabolic and signaling processes. The homeostasis of fatty related pathways is known to be impaired cognitive decline dementia, but the relationship between these disturbances common risk factors, namely ɛ4 allele apolipoprotein E (ApoE-ɛ4) gene sex, remains elusive.In order investigate early alterations associated with acid-related serum metabolome, we here applied targeted metabolomics analysis on a nested...
The implementation of quality control strategies is crucial to ensure the reproducibility, accuracy, and meaningfulness metabolomics data. However, this pivotal step often overlooked within workflow frequently relies on use nonstandardized poorly reported protocols. To address current limitations in respect, we have developed QComics, a robust, easily implementable reportable method for monitoring controlling data quality. protocol operates various sequential steps aimed (i) correct...
The MaPLE study was a randomized, controlled, crossover trial involving adults ≥60 y.o. (n = 51) living in residential care facility during an 8-week polyphenol-rich (PR)-diet. Results from the showed that PR-diet reduced intestinal permeability (IP) older by inducing changes to gut microbiota (GM). present work aimed at studying serum metabolome trial, as further necessary step depict complex crosstalk between dietary polyphenols, GM, and barrier.Serum monitored using semi-targeted...