Jonathan M. Holmes

ORCID: 0000-0002-7663-2034
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About
Contact & Profiles
Research Areas
  • Ophthalmology and Eye Disorders
  • Ophthalmology and Visual Impairment Studies
  • Glaucoma and retinal disorders
  • Visual perception and processing mechanisms
  • Retinopathy of Prematurity Studies
  • Cerebral Venous Sinus Thrombosis
  • Intraocular Surgery and Lenses
  • Pituitary Gland Disorders and Treatments
  • Retinal Diseases and Treatments
  • Corneal surgery and disorders
  • Retinal and Optic Conditions
  • Cerebrospinal fluid and hydrocephalus
  • Neonatal Respiratory Health Research
  • Neonatal Health and Biochemistry
  • Advanced Differential Geometry Research
  • Child Abuse and Related Trauma
  • Neonatal and fetal brain pathology
  • Ophthalmology and Visual Health Research
  • Vestibular and auditory disorders
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Retinal and Macular Surgery
  • Migraine and Headache Studies
  • Tactile and Sensory Interactions
  • Meningioma and schwannoma management
  • Spaceflight effects on biology

University of Arizona
2020-2025

Johns Hopkins University
2020-2023

Cleveland Clinic
2022

Mayo Clinic
2012-2021

University of Cambridge
2021

Hampshire Constabulary
2021

Mayo Clinic in Arizona
2009-2019

WinnMed
1996-2019

Harvard University Press
2013

John F. Kennedy University
2013

To evaluate the effectiveness of treatment amblyopia in children aged 7 to 17 years.At 49 clinical sites, 507 patients with amblyopic eye visual acuity ranging from 20/40 20/400 were provided optimal optical correction and then randomized a group (2-6 hours per day prescribed patching combined near activities for all plus atropine sulfate 12 years) or an (optical alone). Patients whose improved 10 more letters (> =2 lines) by 24 weeks considered responders.In 7- 12-year-olds (n = 404), 53%...

10.1001/archopht.123.4.437 article EN Archives of Ophthalmology 2005-04-01

To compare 2 hours vs 6 of daily patching as treatments for moderate amblyopia in children younger than 7 years.In a randomized multicenter (35 sites) clinical trial, 189 years with the range 20/40 to 20/80 were assigned receive either or combined at least 1 hour per day near visual activities during patching.Main Outcome Measure Visual acuity amblyopic eye after 4 months.Visual improved similar amount both groups. The improvement from baseline months averaged 2.40 lines each group (P =.98)....

10.1001/archopht.121.5.603 article EN Archives of Ophthalmology 2003-05-01

Nuclear extracts derived from HeLa and Drosophila melanogaster KC cell lines have been found to correct single base-base mispairs within open circular DNA heteroduplexes containing a strand-specific, site-specific incision located 808 base pairs the mismatch. Correction in both extract systems is strand specific, being highly biased incised strand. Different homologous set of were processed with different efficiencies (G.T greater than G.G approximately equal A.C C.C), correction was...

10.1073/pnas.87.15.5837 article EN Proceedings of the National Academy of Sciences 1990-08-01

Identifying policies that will cut or constrain US health care spending and growth dominates reform efforts, yet little is known about whether the drivers of levels are same. Policies produce a one-time reduction in level spending, for example by making hospitals more efficient, may do to reduce subsequent annual growth. To identify factors causing grow fastest, we focused on three conditions Medicare population: heart attacks, congestive failure, hip fractures. We found postacute...

10.1377/hlthaff.2012.1262 article EN Health Affairs 2013-05-01

<h3>Importance</h3> A binocular approach to treating anisometropic and strabismic amblyopia has recently been advocated. Initial studies have yielded promising results, suggesting that a larger randomized clinical trial is warranted. <h3>Objective</h3> To compare visual acuity (VA) improvement in children with treated iPad game vs part-time patching. <h3>Design, Setting, Participants</h3> multicenter, noninferiority was conducted community institutional practices from September 16, 2014,...

10.1001/jamaophthalmol.2016.4262 article EN JAMA Ophthalmology 2016-11-03

10.1097/00002341-200209000-00015 article EN Ophthalmic Plastic and Reconstructive Surgery 2002-09-01

<h3>Objective</h3> To evaluate the reliability of a new visual acuity testing protocol for children using isolated surrounded HOTV optotypes. <h3>Methods</h3> After initial pilot and modification, was evaluated Baylor-Video Acuity Tester (BVAT) to present At 6 sites, testability in 178 aged 2 7 years subset 88 children. Twenty-eight percent were classified as having amblyopia. <h3>Results</h3> Using modified protocol, ranged from 24% 2-year-olds 96% 5- 7-year-olds. Test-retest high...

10.1001/archopht.119.9.1345 article EN Archives of Ophthalmology 2001-09-01

<h3>Objective</h3> To compare patching and atropine sulfate as treatments for moderate amblyopia in children 18 months after completion of a 6-month randomized trial. <h3>Methods</h3> In randomized, multicenter (47 sites) clinical trial, 419 younger than 7 years with (20/40 to 20/100 the affected eye) were assigned receive either or eye drops 6 months. Between 2 years, treatment was at discretion investigator. <h3>Main Outcome Measure</h3> Visual acuity amblyopic sound years....

10.1001/archopht.123.2.149 article EN Archives of Ophthalmology 2005-02-01

Among cranial nerve palsies, a third palsy is important because subset caused by life-threatening aneurysms. However, there significant disagreement regarding its incidence and the reported etiologies.To determine etiologies of acquired using population-based method.All newly diagnosed cases from January 1, 1978, through December 31, 2014, in Olmsted County, Minnesota, were identified Rochester Epidemiology Project, record-linkage system medical records for all patient-physician encounters...

10.1001/jamaophthalmol.2016.4456 article EN JAMA Ophthalmology 2016-11-28

Intravitreous bevacizumab (0.25 to 0.625 mg) is increasingly used treat type 1 retinopathy of prematurity (ROP), but there remain concerns about systemic toxicity. A much lower dose may be effective while reducing risk.To find a intravitreous that was than previously for severe ROP, in this study, and could tested future larger studies.Between May 2015 September 2016, 61 premature infants with ROP or both eyes were enrolled masked, multicenter, phase de-escalation study. One eye 10 14...

10.1001/jamaophthalmol.2017.1055 article EN JAMA Ophthalmology 2017-04-27
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