A5024370409- Thyroid Disorders and Treatments
- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Historical and Environmental Studies
- Cancer survivorship and care
- Thyroid Cancer Diagnosis and Treatment
- Cardiovascular and exercise physiology
- Immune Response and Inflammation
- Growth Hormone and Insulin-like Growth Factors
- Exercise and Physiological Responses
- T-cell and B-cell Immunology
- Health and Lifestyle Studies
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Diverse academic and cultural studies
- Sports Performance and Training
- Diabetes and associated disorders
- Childhood Cancer Survivors' Quality of Life
- Italian Fascism and Post-war Society
- Nutrition and Health in Aging
- Galectins and Cancer Biology
- interferon and immune responses
- Hormonal and reproductive studies
- Neuroendocrine Tumor Research Advances
- Lymphatic System and Diseases
University of Chieti-Pescara
2016-2025
Azienda USL di Pescara
2024
Don Carlo Gnocchi Foundation
2022
National Institutes of Health
1995-2007
National Cancer Institute
2007
Chamber of Deputies
2005
National Institute of Diabetes and Digestive and Kidney Diseases
1997-2004
United States Nuclear Regulatory Commission
1998
Royal London Hospital
1992-1993
Queen Mary University of London
1992-1993
Graves' disease (GD) is caused by persistent, unregulated stimulation of thyrocytes thyroid-stimulating antibodies (TSAbs) that activate the TSH receptor (TSHR). We previously reported first small-molecule antagonist human TSHR and showed it inhibited signaling stimulated sera from four patients with GD.Our objective was to develop a better use determine whether inhibition TSAb activation general phenomenon.We aimed chemically modify ligand inhibits 30 GD sera. measured in two vitro systems:...
Toll-like receptors (TLRs) initiate an innate immune response. TLR3 on dendritic cells recognize double-stranded (ds) RNA and then signal increases in cytokines recognition molecules important for cell interactions. In this report, we demonstrate mRNA protein are expressed Fisher rat thyroid line-5 (FRTL-5) functional because incubating with polyinosine-polycytidylic acid causes 1) transcriptional activation of both the nuclear factor kappaB (NF-kappaB)/Elk1 interferon (IFN) regulatory...
Because physical exercise has been widely used for primary and secondary preventions of cardiometabolic diseases arising with menopause, the aim our study was to determine whether participation in aerobic is linked modification spontaneous activity this compensation affects training-related body adaptations.Both before after a 13-week walking training program, 34 postmenopausal women (mean ± SD age, 55.89 3.57 y) were analyzed lipids, adipokines, glucose, insulin plasma levels, as well...
In this study we examined the effect of synthetic peptide thymosin-alpha1 (T(alpha)1) on MHC class I expression in FRTL-5 cells. Treatment with T(alpha)1 increased surface molecules and mRNA, which reached its peak (153 +/- 8 % control value) after 12 h. Chloramphenicol acetyltransferase (CAT) analysis, following transfection a plasmid containing regulatory sequence (or deletion derivatives) CAT reporter gene, electrophoretic mobility shift assay experiments demonstrated that action was at...
A functional thyroid-stimulating autoantibodies (TSAb) assay using a hormone receptor chimera (Mc4) appears to be clinically more useful than the commonly used assay, binding that measures all antibodies without discrimination, in diagnosing patient with Graves' disease (GD).The objective of study was investigate whether an Mc4 can predict relapse/remission hyperthyroidism after antithyroid drug (ATD) treatment patients GD.An prospectively track TSAb activity GD treated ATD over 5-yr...
Quercetin is the most abundant flavonoid present in fruits and vegetables. For its antiproliferative, antiviral, anti-inflammatory antioxidants activities, it an active ingredient of several herbal remedies available as a nutraceutical. Experimental studies performed vitro have demonstrated that quercetin inhibits growth function normal thyroid cells may act disruptor. These effects also been confirmed vivo using rodent models. Some reported ability to interfere with metabolism hormones,...
[Purpose] The aims of this study were to verify the effects on upper limb circumferences and total body extracellular water 10 weeks Nordic Walking (NW) (W), both alone combined with a series exercises created for breast cancer survivors, ISA method. [Subjects Methods] Twenty survivors randomly assigned 4 different training groups evaluated circumferences, water. [Results] who performed NW, method, method (but not alone) showed significantly reduced arm forearm homolateral surgical...
Background: Neonatal thyrotropin (TSH) on dried blood spot (DBS), the most common screening strategy for primary congenital hypothyroidism (CH), is influenced by numerous factors that may hinder a true CH diagnosis. A second test can thus be performed to clarify initial findings, although its application varies among programs. Objectives: The aim of this study was evaluate effect maternal and neonatal TSH levels offer practical recommendations. Methods: We retrospectively analyzed data...
The major histocompatibility complex (MHC) class I gene cAMP response element (CRE)-like site, −107 to −100 base pairs, is a critical component of previously unrecognized silencer, −127 −90 bp, important for thyrotropin (TSH)/cAMP-mediated repression in thyrocytes. TSH/cAMP induced-silencer activity associated with the formation novel complexes 38-base pair whose appearance requires CRE and involves ubiquitous thyroid-specific proteins as follows: CRE-binding protein, Y-box protein termed...
Quercetin is the most consumed flavonoid present in fruits and vegetables. There has been increased interest possible health benefits of quercetin other flavonoids. Because it reported that these compounds have some antithyroid properties, we were interested whether, by what mechanism, might regulate thyroid cell growth function. In this report show inhibits association with inhibition insulin-modulated phosphatidylinositol 3-kinase-Akt kinase activity. Furthermore, decreases TSH-modulated...
We hypothesized that physical exercise in postmenopausal women could interfere with the molecular interrelationship of immune-endocrine system and be effective even whom training determined a reduction spontaneous activity (SPA). For this reason, we investigated effects an aerobic program on plasma dehydroepiandrosterone sulfate (DHEA-S) cytokine levels relationship to SPA modification.Thirty-two (mean [SD] age, 56.38 [4.33] y) were enrolled study. Inclusion criteria as follows: age younger...