A5049919230- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Atmospheric chemistry and aerosols
- Metabolomics and Mass Spectrometry Studies
- Atmospheric and Environmental Gas Dynamics
- Petroleum Processing and Analysis
- Atmospheric Ozone and Climate
- Analytical Chemistry and Chromatography
- Vehicle emissions and performance
- Advanced Chemical Sensor Technologies
- Nutritional Studies and Diet
- Gut microbiota and health
- Chromatography in Natural Products
- Hydrocarbon exploration and reservoir analysis
- Advanced Chemical Physics Studies
- Air Quality Monitoring and Forecasting
- Indoor Air Quality and Microbial Exposure
- Fungal Biology and Applications
- Diet and metabolism studies
- Pharmacological Effects of Natural Compounds
- Carcinogens and Genotoxicity Assessment
- Identification and Quantification in Food
- Fermentation and Sensory Analysis
- Per- and polyfluoroalkyl substances research
- Ginseng Biological Effects and Applications
Mahidol University
2019-2024
Siriraj Hospital
2019-2024
Environment and Climate Change Canada
2015-2021
Oregon State University
2008-2014
Atmospheric particulate matter with diameter <2.5 um (PM2.5) was collected at Peking University (PKU) in Beijing, China before, during, and after the 2008 Olympics analyzed for black carbon (BC), organic (OC), lower molecular weight (MW < 300) MW302 Polycyclic Aromatic Hydrocarbons (PAHs), nitrated PAHs (NPAHs) oxygenated (OPAHs). In addition, direct indirect acting mutagenicity of PM2.5 potential DNA damage to human lung cells were also measured. Significant reductions BC (45%), OC (31%),...
The heterogeneous reactions of ambient particulate matter (PM)-bound polycyclic aromatic hydrocarbons (PAHs) and nitro-PAHs (NPAHs) with NO3/N2O5, OH radicals, O3 were studied in a laboratory photochemical chamber. Ambient PM2.5 PM10 samples collected from Beijing, China, Riverside, California, exposed under simulated atmospheric long-range transport conditions for NO3 radicals. Changes the masses 23 PAHs 20 NPAHs, as well direct indirect-acting mutagenicity PM (determined using Salmonella...
This air synthesis review presents the current state of knowledge on sources, fates, and effects for polycyclic aromatic compounds (PACs) related chemicals released to in oil sands region (OSR) Alberta, Canada. Through implementation Joint Canada–Alberta Oil Sands Monitoring Program 2012 a vast amount new information PACs has been acquired through directed monitoring research projects reported scientific community public. addresses questions cumulative informs sustainable management resource...
Reactions of ambient particles collected from four sites within the Los Angeles, CA air basin and Beijing, China with a mixture N2O5, NO2, NO3 radicals were studied in an environmental chamber at pressure temperature. Exposures system resulted degradation particle-bound PAHs formation molecular weight (mw) 247 nitropyrenes (NPYs) nitrofluoranthenes (NFLs), mw 273 nitrotriphenylenes (NTPs), nitrobenz[a]anthracenes (NBaAs), nitrochrysene (NCHR), 297 nitrobenzo[a]pyrene (NBaP). The distinct...
Based on distinct land-use categories, a sampling campaign was carried out at eight locations across Toronto and the Greater Area in 2016-2017. Source sectors' dependent patterns of atmospheric concentrations 9 organophosphate esters (OPEs), polybrominated diphenyl ethers (PBDEs) 5 novel flame retardants (NFRs) showed dominance OPEs PBDEs highly commercialised urban traffic sites, while NFRs, were dominant residential sites. Overall, average Σ9OPEs (1790 pg/m3) two orders magnitude higher...
A pilot study was initiated in 2018 under the Global Atmospheric Passive Sampling (GAPS) Network named GAPS-Megacities. This included 20 megacities/major cities across globe with goal of better understanding and comparing ambient air levels persistent organic pollutants other chemicals emerging concern, to which humans residing large are exposed. The first results from initial period sampling reported for 19 several classes flame retardants (FRs) including organophosphate esters (OPEs),...
The heterogeneous reactions of benzo[a]pyrene-d12 (BaP-d12), benzo[k]fluoranthene-d12 (BkF-d12), benzo[ghi]perylene-d12 (BghiP-d12), dibenzo[a,i]pyrene-d14 (DaiP-d14), and dibenzo[a,l]pyrene (DalP) with NO2, NO3/N2O5, OH radicals were investigated at room temperature atmospheric pressure in an indoor Teflon chamber novel mono-NO2-DaiP mono-NO2-DalP products identified. Quartz fiber filters (QFF) used as a reaction surface the filter extracts analyzed by GC/MS for nitrated-PAHs (NPAHs) tested...
Extracts of passive air samples collected from 15 sampling network sites across the Athabasca Oil Sands region were used to explore application in vitro assays for mutagenicity (Salmonella mutation assays) and cytotoxicity (lactate dehydrogenase assay) assess toxicity mixture. The monitoring polycyclic aromatic compounds (PACs) PAC transformation products, including nitrated hydrocarbons (NPAHs) oxygenated (OPAHs) was then linked potential air. PACs during April May 2014 elevated near mining...
Abstract. Conventional passive air samplers (PAS) and dry deposition (PAS-DD) were deployed along a 90 km south–north transect at five sites in the Athabasca oil sands region (AOSR) during October to November 2015. The purpose was compare characterize performance of two sampling methods for targeted compounds across range site types. Samples analyzed polycyclic aromatic (PACs), nitrated hydrocarbons (NPAHs), oxygenated PAHs (OPAHs). ΣPAC ΣNPAH concentrations highest PAS PAS-DD AMS5, which is...
Short-chain fatty acids (SCFAs) are involved in important physiological processes such as gut health and immune response, changes SCFA levels can be indicative of disease. Despite the importance SCFAs human disease, reference values for fecal plasma concentrations healthy individuals scarce. To address this gap current knowledge, we developed a simple reliable derivatization-free GC-TOFMS method quantifying individuals. We targeted six linear- seven branched-SCFAs, obtaining recoveries...
A new method is presented for measuring atmospheric concentrations of trace metals in airborne particulate matter using polyurethane foam (PUF) disk passive air samplers (PUF-PASs) and dry deposition (PAS-DDs), which until now have mainly been used to assess organic pollutants air. field calibration study was conducted at one the sites where measurements were available conventional methods. Uptake profiles PUF-PASs PAS-DDs linear over full 56 days that deployed. The results confirm ability...
Two dimensional GC (GC × GC)-time-of-flight mass spectrometry (TOFMS) has been used to improve accurate metabolite identification in the chemical industry, but this method not applied as readily biomedical research. Here, we evaluated and validated performance of high resolution GC-TOFMS against that for metabolomics analysis two different plasma matrices, from healthy controls (CON) diabetes mellitus (DM) patients with kidney failure (DM KF). We found outperformed traditional terms...
Hericium erinaceus is an edible mushroom with diverse pharmaceutical applications. Although this attractive source of natural products for cancer treatment, little known about the bioactive compounds from mushroom, which may possess antibreast activity. Here, we report isolation and structure elucidation new compounds, 5'-hydroxyhericenes A-D (1-4) as inseparable mixture, together (5-16) fruiting body H. erinaceus. Based on NMR spectroscopic data MS fragmentation analysis, a previously...
The collision cross-sections (CCS) measurement using ion mobility spectrometry (IMS) in combination with mass (MS) offers a great opportunity to increase confidence metabolite identification. However, owing the lack of sensitivity and resolution, IMS has an analytical challenge studying CCS values very low-molecular-weight metabolites (VLMs ≤ 250 Da). Here, we describe method ultrahigh-performance liquid chromatography (UPLC) coupled traveling wave mobility-quadrupole-time-of-flight...
Mining-related activities in the Alberta Oil Sands Region (AOSR) are known to emit polycyclic aromatic hydrocarbons (PAHs) and related compounds ambient air. This is a concern due toxicity of PAHs, including their transformation products such as nitrated (NPAHs) oxygenated (OPAHs) PAHs. first study that provided more extensive outlook into sources, occurrence air, spatial seasonal patterns NPAHs OPAHs AOSR by using passive air sampling. A sampling campaign from 2013 2016 revealed...
The current gold standard for classifying lupus nephritis (LN) progression is a renal biopsy, which an invasive procedure. Undergoing series of biopsies monitoring disease and treatments unlikely suitable patients with LN. Thus, there urgent need non-invasive alternative biomarkers that can facilitate LN class diagnosis. Such will be very useful in guiding intervention strategies to mitigate or treat Urine samples were collected from two independent cohorts. Patients classified into...
Pyranonaphthoquinones (PNQs) are important structural scaffolds found in numerous natural products. Research interest these specialized metabolites lies their occurrence and therapeutic activities. Nonetheless, research progress has thus far been hindered by the lack of analytical standards methods for both qualitative quantitative analysis. We report here that various parts Ventilago harmandiana rich sources PNQs. developed an ultraperformance liquid chromatography–electrospray ionization...
In the present study, suitability and sensitivity of different in vitro toxicity endpoints were determined to evaluate distinguish specific contributions polycyclic aromatic carbon (PAC) mixtures from various sites Toronto (Canada), pulmonary toxicity. Air samples collected for two-month periods April 2014 March 2015 one location, August 2016 2017 multiple locations reflecting geographical areas Toronto, Greater Area, with varying source emissions including background, traffic, urban,...
Abstract Two-dimensional gas chromatography–time-of-flight mass spectrometry (GC × GC–TOFMS) provides a large amount of molecular information from biological samples. However, the lack comprehensive compound library or customizable bioinformatics tool is currently challenge in GC GC–TOFMS data analysis. We present an open-source deep learning (DL) software called contour regions interest (ROI) identification, simulation and untargeted metabolomics profiler (CRISP). CRISP integrates multiple...