A5025044372- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Hair Growth and Disorders
- Skin Protection and Aging
- melanin and skin pigmentation
- Skin and Cellular Biology Research
- Silk-based biomaterials and applications
- Burn Injury Management and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Planarian Biology and Electrostimulation
- Reconstructive Surgery and Microvascular Techniques
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Esophageal and GI Pathology
- Cutaneous Melanoma Detection and Management
- Genetic and rare skin diseases.
- Bone fractures and treatments
- Advancements in Transdermal Drug Delivery
- Corneal Surgery and Treatments
- Pluripotent Stem Cells Research
- Pressure Ulcer Prevention and Management
- Tracheal and airway disorders
- Surgical Sutures and Adhesives
- Angiogenesis and VEGF in Cancer
- Lymphatic System and Diseases
University Children's Hospital Zurich
2015-2025
University of Zurich
2009-2025
Universitätskinderklinik
2019
Zero to Three
2014
Boston Children's Hospital
2014
Marymount University
2006
Initial take, development, and function of transplanted engineered tissue substitutes are crucially dependent on rapid adequate blood perfusion. Therefore, the development rapidly efficiently vascularized grafts is vital for engineering regenerative medicine. Here we report construction a network highly organotypic capillaries in substitutes. We employed three-dimensional culture system consisting human microvascular endothelial cells. These were reproducibly expanded at high purity...
Extensive full-thickness skin loss, associated with deep burns or other traumata, represents a major clinical problem that is far from being solved. A promising approach to treat large defects the use of tissue-engineered analogues nearly normal anatomy and function. In addition excellent biological properties, such substitutes should exhibit optimal structural mechanical features. This study aimed test novel dermo-epidermal based on collagen type I hydrogels, physically strengthened by two...
In our laboratory, we have been using human pigmented dermo-epidermal skin substitutes for short-term experiments since several years. Little is known, however, about the long-term biology of such constructs after transplantation. We constructed human, melanocyte-containing different (light and dark) pigmentation types studied them in a animal experiment. Developmental maturational stages epidermal dermal compartment as well signs homoeostasis were analysed 15 weeks Keratinocytes,...
Abstract Limited donor sites and poor long-term outcomes with standard treatment for large skin defects remain a huge problem. An autologous, bilayered, laboratory-grown substitute (denovoSkin) was developed to overcome this problem has shown be safe in 10 pediatric patients Phase I clinical trial after transplantation. The goal of article report on 48-month results. participants the phase were followed up at yearly visits 5 years Safety parameters, including occurrence adverse events,...
It has been shown in vitro that melanocyte proliferation and function palmoplantar skin is regulated by mesenchymal factors derived from fibroblasts. In this study, we investigated vivo the influence of mesenchymal-epithelial interactions human tissue-engineered substitutes reconstructed palmar- nonpalmoplantar-derived Tissue-engineered dermo-epidermal analogs based on collagen type I hydrogels were populated with either palmar or nonpalmoplantar fibroblasts seeded melanocytes keratinocytes....
Background: Extended avulsion injuries are associated with significant loss of skin and subcutaneous fat, leaving the reconstructive surgeon challenge substituting all tissues lost in best possible way. We wanted to test whether combined use a Vacuum Assisted Closure system (VAC) Integra Dermal Regeneration Template (IDRT) matched required treatment profile encompassing initial control infection, remodeling body contours, reconstruction near normal skin.
Self-filling, hydrogel-based osmotic tissue expanders have been successfully used for several years, mainly in adult patients. We wanted to test this novel device pediatric plastic and reconstructive surgery.Between November 2004 September 2009, we implanted 53 following standard surgical principles a total of 30 children adolescents with burn scars, congenital nevi, alopecia, or foot deformities.All reached their predicted volume within 6 weeks 51 (96.2%) produced sufficient amount...