A5038924906- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Protist diversity and phylogeny
- Microbial Metabolic Engineering and Bioproduction
- Parasitic Infections and Diagnostics
- Genomics and Chromatin Dynamics
- Gene Regulatory Network Analysis
- RNA Research and Splicing
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Insect symbiosis and bacterial influences
- CRISPR and Genetic Engineering
- Plant Parasitism and Resistance
- Echinoderm biology and ecology
University of Oxford
2016-2018
Genomes are composed of long strings nucleotide monomers (A, C, G and T) that either scavenged from the organism's environment or built metabolic precursors. The biosynthesis each differs in atomic requirements with different nucleotides requiring quantities nitrogen atoms. However, impact relative availability dietary on genome composition codon bias is poorly understood. Here we show differential availability, due to differences inputs, a major determinant synonymous use both bacterial...
Antisense transcription is widespread in genomes. Despite large differences gene size and architecture, we find that yeast human genes share a unique, antisense transcription-associated chromatin signature. We asked whether this signature related to biological function for transcription. Using quantitative RNA-FISH, observed changes sense transcript distributions nuclei cytoplasm as levels were altered. To determine the mechanistic underlying these distributions, developed mathematical...
Most amino acids are encoded by multiple synonymous codons. However, codons not used equally, and this biased codon use varies between different organisms. It has previously been shown that both selection acting to increase translational efficiency decrease biosynthetic cost contribute differences in bias. it is unknown how these two factors interact or they affect molecular sequence evolution. Through analysis of 1320 bacterial genomes, we show genes subject multi-objective selection-driven...
Abstract Background Most amino acids are encoded by multiple synonymous codons. However codons not used equally and this biased codon use varies between different organisms. It has previously been shown that both selection acting to increase translational efficiency decrease biosynthetic cost contribute differences in bias. However, it is unknown how these two factors interact or they affect molecular sequence evolution. Results Through analysis of 1,320 bacterial genomes we show genes...
Abstract Antisense transcription is widespread in genomes. Despite large differences gene size and architecture, we find that yeast human genes share a unique, antisense transcription-associated chromatin signature. We asked whether this signature related to biological function for transcription. Using quantitative RNA-FISH, observed changes sense transcript distributions nuclei cytoplasm as levels were altered. To determine the mechanistic underlying these distributions, developed...