A5091016192- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Breast Lesions and Carcinomas
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Reconstructive Facial Surgery Techniques
- Medical Imaging Techniques and Applications
- COVID-19 and healthcare impacts
- Mindfulness and Compassion Interventions
- BRCA gene mutations in cancer
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cancer Genomics and Diagnostics
- Economic and Financial Impacts of Cancer
- Clinical practice guidelines implementation
- Anesthesia and Pain Management
- Cancer Treatment and Pharmacology
- Drug Transport and Resistance Mechanisms
- Advances in Oncology and Radiotherapy
- Colorectal and Anal Carcinomas
- Cancer Risks and Factors
- Head and Neck Cancer Studies
Royal Stoke University Hospital
2014-2024
University Hospitals of North Midlands NHS Trust
2015-2024
Tawam Hospital
2024
East Cheshire NHS Trust
2024
United Lincolnshire Hospitals NHS Trust
2024
James Cook University Hospital
2023
Keele University
2015-2020
Royal Liverpool and Broadgreen University Hospital NHS Trust
2017
Birmingham City Hospital
2012-2013
University Hospitals Birmingham NHS Foundation Trust
2013
Abstract Introduction Prepectoral techniques are becoming standard of care for implant-based breast reconstruction due to reduced impact on chest wall function and improved patient satisfaction. Evidence support these benefits, however, is lacking. Here, patient-reported outcomes (PROs) prepectoral (PPBR) in the Pre-BRA cohort reported. Methods Women undergoing PPBR after mastectomy cancer or risk reduction between July 2019 December 2020 were recruited. Participants completed BREAST-Q...
The last two decades have seen significant changes in surgical management of breast cancer. offer immediate reconstruction (IBR) following mastectomy is currently standard practice. Skin sparing and nipple with implant-based IBR emerged as oncologically safe treatment options. Prepectoral implant placement complete coverage acellular dermal matrix (ADM) eliminates the need to detach muscle from underlying chest wall contrast subpectoral technique. We report short-term outcomes a multicentre...
Perforator artery flaps based on the branches of intercostal arteries and lateral thoracic can be used for reconstruction after breast-conserving surgery (BCS). Although described more than a decade ago, these have not been adopted widely in clinical practice. We report short-term long-term surgical outcomes partial breast using chest wall perforator from prospective multicenter audit.All patients operated BCS or January 2015 to October 2018 were included analysis. Oncoplastic surgeons with...
The ATP-binding cassette transporter A1 (ABCA1) facilitates cholesterol efflux from cells, a key process in reverse transport. Whereas previous investigations focused on mutations causing impaired ABCA1 function, we assessed the role of human carotid atherosclerotic disease.We compared mRNA and protein levels ABCA1, one its regulators, liver X receptor alpha (LXRalpha), between minimally grossly arterial tissue. We established LXRalpha gene expression by real-time quantitative polymerase...
Background: Implant-based immediate breast reconstruction (IBR) is the most common technique for post-mastectomy reconstructions in United Kingdom (UK). Subpectoral implant placement conventional method of reconstruction. Placement subcutaneous pocket covered by an acellular dermal matrix (ADM) a relatively recent approach. We report comparative analysis prepectoral versus subpectoral approach implant-based IBR from single institution UK. Methods: Retrospective prospectively maintained data...
Prepectoral breast reconstruction (PPBR) has recently been introduced to reduce postoperative pain and improve cosmetic outcomes in women having implant-based procedures. High-quality evidence support the practice of PPBR, however, is lacking. Pre-BRA an IDEAL stage 2a/2b study that aimed establish safety, effectiveness, stability PPBR before definitive evaluation RCT. The short-term safety endpoints at 3 months after surgery are reported here.Consecutive patients electing undergo immediate...
Background: Atherosclerotic plaque behaviour is influenced by intraplaque inflammation, matrix turnover, and the lipid core volume. Peroxisome proliferator activated receptor γ (PPARγ) modulates atherosclerosis its anti-inflammatory anti-protease activity. PPARγ promotes efflux through liver X α (LXRα) ATP binding cassette transporter A1 (ABCA1). Matrix metalloproteinase 9 (MMP-9) cyclooxygenase 2 (COX-2) are implicated in instability. Aims: To assess expression of these genes occlusive...
Parotid gland metastases from breast cancer are an extremely rare and unusual event with a limited number of cases recorded in the literature. A 71-year-old woman history ductal adenocarcinoma left presented to maxillofacial clinic asymptomatic swelling parotid gland. The presentation occurred 21 years after she underwent treatment for recurrent cancer. Investigations led diagnosis metastasis which was oestrogen receptor progesterone positive negative. Positron emission tomography scan...
BACKGROUND:Axillary Ultrasound (AUS) is now performed as a protocol in every newly diagnosed breast cancer most European countries. It an inexpensive and sensitive tool hands of trained operator. All AUS negative patients undergo Sentinel Lymph Node Biopsy (SLNB), while positive pati ents bypass SLNB axillary nodal clearance (ANC) standard protocol. We wish to analyse these two groups see if ANC can be foregone patients. AIMS AND OBJECTIVES:To compare the disease burden early patients, with...
ATP-binding cassette transporter A1 (ABCA1) mediates the transport of cholesterol and phospholipids from cells to lipid-poor HDL maintains cellular lipid homeostasis. Impaired ABCA1 function plays a role in disorders, cardiovascular disease, atherosclerosis, metabolic disorders. Despite clinical importance ABCA1, no method is available for quantifying protein. We developed sensitive indirect competitive ELISA measuring protein human tissues using commercial peptide polyclonal anti-ABCA1...
A 79-year-old woman presented with a 4 day history of central abdominal pain and vomiting. Clinical examination revealed distended abdomen predominantly right sided tenderness. Following an initial period supportive treatment pending further imaging, evolving signs became evident. Based on the suspicion perforated hollow viscus, emergency laparotomy was carried out. Operative findings were Meckel’s diverticulum evidence pressure necrosis perforation near its apex, which due to 6 cm...
Acute pancreatitis is recognised to cause both local and extra pancreatic systemic complications. Sequelae like pseudocyst of the pancreas can further be complicated by infection, intracystic haemorrhage rupture with high mortality morbidity. Extra manifestations include alterations in blood coagulation factors pro-thrombotic tendencies. We report an atypical presentation a into peritoneal cavity, presenting acute onset paraplegia. Considering serious consequences this pathology, index...
Objective: Chronic venous disease has made a considerable socio-economical impact in the developed world due to its high prevalence and cost of management. Venous hypertension gives rise significant signs symptoms that are indications for treatment. Though mainstay treatment currently is surgery, it may not be ideal choice some cases considering heterogeneous spectrum disease. Recent alternative endovenous treatments have shown lot promise successfully treating this condition. The aim review...