Abnormalities in insulin hormone levels leads to a hyperglycemic condition of diabetic mellitus. Hyperglycemia seriously induces organ and system destructions. The excessive accumulation collagen fiber deposits occurs inflammatory reorganization processes chronic liver diseases type I insulin-dependent diabetes. Regarding the research objective, glabridin (GLB), an active compound licorice, was used as daily supplement (40 mg/kg) order decrease hepatocyte destruction deposition tissue...

BACKGROUND Small blood vessels in the eyes are more susceptible to injury, which can lead complications. However, since diabetic retinopathy is often a serious clinical condition, most of this study focuses on vascular system choroid. As part study, we looked at how gymnemic acid (from Gymnema sylvestre ) and glabridin Glycyrrhiza glabra , or licorice) might help rats’ choroid structural change vessels. AIM To explore effects changes choroidal layer choriocapillaris as well expression...

Diabetes-related osteoporosis has been known to be a consequence of oxidative stress caused by excessive reactive oxygen species (ROS) production in the tissues. Despite increase number individuals with diabetes-related year on year, there is still no effective drug that does not induce adverse side effects. Glabridin, which exerts hypoglycemic effects and possesses antioxidant properties, may have beneficial treatment osteoporosis. In this study, we aimed investigate preventive glabridin...

Background: Diabetic nephropathy (DN) is primarily caused by hyperglycemia-induced angiogenesis and fibrosis. It has been reported that edible bird's nest (EDB), a traditional Chinese medicine, may prevent insulin resistance. However, its influence on diabetic remains unclear. This research investigated the impact of EDB glomeruli peritubular capillaries in induced rat models. Methods: Wistar rats were injected with streptozotocin (STZ) to induce diabetes mellitus (DM). rodents treated at...

(Malayan pit viper) is a medically important snake species that widely distributed across Southeast Asia. Systemic coagulopathy causing severe haemorrhage and local tissue injury commonly observed following

An understanding of snake venom pharmacokinetics is essential for determining clinical outcomes envenoming and developing therapeutic approaches to the treatment envenoming, especially regarding timing optimal dosage antivenom administration. Daboia siamensis (Eastern Russell’s viper) causes systemic coagulopathy severe hemorrhage including acute kidney injury. These toxic can be diminished by administration high quantities viper antivenom. This study aimed determine correlation between...

The brain is a vital organ that requires constant blood supply. Stroke occurs when the supply to specific parts of reduced; diabetes an autonomous risk factor for stroke. present study aimed investigate potential vascular protective effect gymnemic acid (GM) by assessing morphological changes microvasculature, along with VEGFA and angiopoietin-1 (Ang-1) protein expression in brains diabetic rats. Rats were divided into five groups, including control, control rats (CGM), rendered single...

Diabetes is characterized by high blood glucose level termed hyperglycemia affecting skeletal muscle structure and function an unclear molecular mechanism.This study aimed to investigate the effect underlying mechanism(s) of on both in vitro vivo.Treatment with hyperglycemic condition (25 mM) for 48 h significantly inhibited C2C12 myoblast proliferation detected MTT assay whilst flow cytometry revealed interruption cell cycle at subG1 G2/M phases.An exposure decreased myosin heavy chain...

Background: A high prevalence of atherosclerotic vascular lesions has been associated with renal disease and diabetes is a major cause for increasing deaths from cardiovascular disease. The present study aimed to determine the beneficial effects gymnemic acids on kidney microvasculature establish their anti-angiogenic properties that are related expression endothelial growth factor (VEGF) protein segmental interlobar arteries in induced diabetic rats. Methods: Rats were divided into five...

Diabetic mellitus is a complex and serious disorder characterized by poor glycemic control leading to tendon architectural alterations inflammation. This study aimed investigate the protective effects of glabridin, polyphenolic flavonoid, on architecture inflammation Achilles in streptozotocin-induced type 1 diabetic rats. Type diabetes was induced single intraperitoneal injection streptozotocin (60 mg/kg b.wt.). After confirmation state, rats were divided into four groups; normal control, +...

The grey oyster mushroom [Pleurotus sajor-caju (Fr.) Sing.], an edible mushroom, has been known as a source of bioactive compounds, including polysaccharides. Polysaccharides from this have shown to possess antidiabetic activity both in vivo and vitro. However, mechanism partially purified or polysaccharides the gray not characterized. In study, we extracted mushrooms used them investigate context C2C12 myotubes. Using Fourier Transform Infrared spectroscopy (FTIR) analysis enzymatic assay,...

Background: Vascular diseases from diabetes typically result in conditions that interfere with the microvascular functions, such as erectile dysfunction (ED) of penis. It is unrevealed which morphological changes microvasculature penis may treatment and supplementation curcumin.Objective: This study aims to determine effects curcumin, active compound turmeric, on penile experimentally induced diabetic rats.Methods: Rat were divided into three groups, control © (DM). Diabetic rats...

This study was to explore the effects of glabridin and gymnemic acid on structural changes choroidal layer as well expression VEGF CD31 in diabetic rats. The animals were separated into five groups: control group (C), (DM), rats treated with 40 mg/kg body weight (DM+GB), 400 (DM+GM), glyburide 4 (DM+GR). There has been an increase thickness both choroid wall arteries group. A decrease vascularity neovascularization can be found DM After eight weeks experimentation, arteries, diameter lumen...

Diabetic eye disease, known as diabetic retinopathy (DR), is one of the problems that can arise from having high blood sugar for an extended period. This study aimed to investigate effect edible bird's nest (EBN) on retinal angiogenesis in rats.

Abstract Small blood vessels in the eyes are more susceptible to injury, which can lead complications. However, since diabetic retinopathy is often a serious clinical condition, most of this study focuses on vascular system choroid. As part study, we looked at how gymnemic acid (from Gymnema sylvestre ) and glabridin Glycyrrhiza glabra , or licorice) might help rats’ choroid thickness vessels. The aim was explore effects structural changes choroidal layer as well expression VEGF CD31 rats....

Abnormalities in the secretion of insulin are cause pathology and complications diabetic patients. The aim this study was to investigate anti-diabetic effect polysaccharide extracts from split gill mushroom type 2 diabetes rats administered a low dose streptozotocin (STZ) combination with high-fat diet.

Abstract Calloselasma rhodostoma (Malayan pit viper) is a medically important snake species found widely distributed across Southeast Asia. Systemic coagulopathy causing severe hemorrhage, and local tissue injury, are commonly following C. envenoming. However, the unusual nephrotoxicity congestive heart failure have been reported in patient who had long length of hospital stay. In this study, we determined effect envenoming on cardiovascular disturbances morphological changes liver, kidney...

Diabetes mellitus is characterised by high blood glucose level termed hyperglycaemia (HG). It has been reported to affect skeletal muscle inducing atrophy and protein degradation leading impairment of function. This study aimed investigate the effects HG on expression myogenic regulatory factor genes in progenitor cells muscle. The number C2C12 myoblasts cultured condition was significantly decreased compared control dose time dependent manner. In addition, Ki-67 positive nuclei after...

Several studies highlight beneficial effect of glabridin as an anti-hyperglycemic agent. However, the protective mechanisms on improvement pancreatic islets damage due to streptozotocin (STZ) exposure have not been adequately investigated. In present study, we aimed elucidate effects restoration islet architecture, at least in part by restoring collagen I and fibronectin, through activation protein kinase Cs (PKCs) transforming growth factor (TGF)-β1 STZ-induced β-cell injuries....