A5007277218- Saffron Plant Research Studies
- Analytical chemistry methods development
- Neurological Disease Mechanisms and Treatments
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Analytical Chemistry and Chromatography
- Flavonoids in Medical Research
- Neurological Disorders and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Advanced biosensing and bioanalysis techniques
- Hydrogels: synthesis, properties, applications
- Forensic Toxicology and Drug Analysis
- Glaucoma and retinal disorders
- Nanoparticle-Based Drug Delivery
- Traditional Chinese Medicine Analysis
- Surfactants and Colloidal Systems
- RNA Interference and Gene Delivery
- Advancements in Transdermal Drug Delivery
- Medicinal Plants and Bioactive Compounds
- Hedgehog Signaling Pathway Studies
- Biosensors and Analytical Detection
- Ocular Infections and Treatments
- Ginkgo biloba and Cashew Applications
- Carbon and Quantum Dots Applications
- Quantum Dots Synthesis And Properties
Mashhad University of Medical Sciences
2015-2024
Target (United States)
2022
Iran University of Science and Technology
2015
Cerebral ischemia produces brain damage and related behavioral deficits such as memory. In this study, a rat model of chronic cerebral hypoperfusion was used to determine whether saffron extract crocin, which are potent antioxidants free radical scavengers, can reduce vascular cognitive impairment. Male adult Wistar rats were administered different doses an aqueous solution crocin or hydroalcohol intraperitoneally (i.p.) 5 days after permanent occlusion the common carotid arteries. Spatial...
Cancer is known as one of the most significant causes death worldwide, and, in spite novel therapeutic methods, continues to cause a considerable number deaths. Targeted molecular diagnosis and therapy using aptamers with high affinity have become popular techniques for pathological angiogenesis cancer scientists. In this paper, several aptamer-based diagnostic such aptamer–nanomaterial conjugation, aptamer–drug conjugation (physically or covalently), biosensors, which been successfully...
In this study, total crocin was extracted from saffron stigmas using crystallization method. Ethanol 80% selected as the best extraction solvent. Crystallization process carried out in one and two steps at different temperatures. used medium. Crocin crystals obtained first had low purity thus were subjected to second crystallization. The higher yielded -5 degrees C. of studied UV-visible spectrophotometery HPLC comparison with Fluka product methanolic extract stigmas. results indicated that...
A new molecularly imprinted polymer for extraction of crocin from saffron stigmas was prepared using gentiobiose (a glycoside moiety in structure) as a template. Crocin binding to (Gent-MIP) studied comparison with blank nonimprinted aqueous media. Affinity the Gent-MIP more than at all concentrations. In Scatchard analysis, number sites each gram (maximum sites) and dissociation constant were 18.4 micromol/g 11.2 microM, respectively. The then used sorbent an SPE method isolation...
This study investigated the effects of different celery (Apium graveolens) seed extracts on blood pressure (BP) in normotensive and deoxycorticosterone acetate–induced hypertensive rats. The hexanic, methanolic, aqueous-ethanolic were administered intraperitoneally their BP heart rate (HR) evaluated comparison with spirnolactone as a diuretic positive control. Also, amount n-butylphthalide (NBP), an antihypertensive constituent, each extract was determined by HPLC. results indicated that all...
The effects of saffron (Crocus sativus L.) on mood disorders have already been established. More recently, its anti-neoplastic provoked a great attention. This study aims to assess the crocin administration during doxorubicin-based chemotherapy breast cancer anxiety, depression, and toxicity profile. Seventy-two patients with non-metastatic Her2/neu positive or triple negative were enrolled randomly assigned receive either 30 mg/day placebo [2:2]. Beck's Depression Anxiety Inventories used...
Abstract The aim of this work was to study the influence methacrylic acid (MAA) as a comonomer and application molecular imprinting technique on loading release properties weakly crosslinked 2‐hydroxyethyl methacrylate (HEMA) hydrogels, with view toward their use reloadable soft contact lenses for administration prednisolone acetate (PA). hydrogels were prepared HEMA (95.90–98.30 mol %) backbone monomer, ethylene glycol dimethacrylate (140 m M ) crosslinker, MAA (0, 50, 100, or 200...
Abstract Two clozapine (CLZ) imprinted polymers were prepared by bulk and precipitation methods. Methacrylic acid ethylene glycol dimethacrylate (EDMA) used as functional crosslinker monomers, respectively. The mean diameter particle size distribution of the (P‐MIP) nonimprinted (P‐NIP) particles obtained in method examined. A conventional batch‐adsorption test was applied for characterization CLZ–polymer interaction. Dissociation constant ( K D ) maximum binding sites B max calculated using...
In the present work a series of imprinted (MIPs) and non-imprinted (NIPs) hydrogels were prepared using 2-hydroxyethyl methacrylate (HEMA) as backbone monomer, ethylene glycol dimethacrylate (EGDMA) cross-linker methacrylic acid (MAA) functional monomer dorzolamide (DZD) template molecule. Different concentrations MAA (0, 100, 200, 400 mM) used for preparation NIPs. Two DZD: molar ratios (1:8 1:4) mM also applied in imprinting process. The (0.4 mm thickness) synthesized by thermal...
Purpose: In the present work, effect of monomer composition on silver nanoparticles' (SNPs) binding capacity hydrogels was investigated and their antibacterial efficacy evaluated.Materials methods: Three series poly-hydroxyethyl methacrylate (HEMA) were prepared using methacrylic acid (MAA), methacrylamide (MAAM), 4-vinylpyridine (4VP) as co-monomers, ethylene glycol dimethacrylate (EGDMA) cross-linker. SNPs evaluated in different concentrations (2, 10, 20 ppm). vitro activity SNP-loaded...