A5017956360- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Pain Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Axon Guidance and Neuronal Signaling
- Botulinum Toxin and Related Neurological Disorders
- Angiogenesis and VEGF in Cancer
- Spinal Cord Injury Research
- Neurogenetic and Muscular Disorders Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Hereditary Neurological Disorders
Universidad de Sevilla
2017-2024
University College London
2024
Medawar Building for Pathogen Research
2024
Texas A&M Health Science Center
2018
Karolinska Institutet
2018
Ruhr University Bochum
2018
University of Kansas
2018
Chronic pain presents an enormous personal and economic burden there is urgent need for effective treatments. In a mouse model of chronic neuropathic pain, selective silencing key neurons in spinal signalling networks with botulinum constructs resulted reduction behaviours associated the peripheral nerve. However, to establish clinical relevance it was important know how long this period lasted. Now, we show that neuronal concomitant mechanical thermal hypersensitivity lasts up 120d...
Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease characterized by severe muscle weakness mainly due to degeneration and death of motor neurons. A peculiarity the neurodegenerative processes variable susceptibility among distinct neuronal populations, exemplified contrasting resilience neurons innervating ocular system more vulnerable facial hypoglossal The crucial role vascular endothelial growth factor (VEGF) as neuroprotective in nervous well-established since deficit...
Extraocular motoneurons resist degeneration in diseases such as amyotrophic lateral sclerosis. The main objective of the present work was to characterize presence neurotrophins extraocular and muscles adult rat. We also compared these results with those obtained from other cranial motor systems, facial hypoglossal, which indeed suffer neurodegeneration. Immunocytochemical analysis used describe expression nerve growth factor, brain-derived neurotrophic factor neurotrophin-3 oculomotor,...
Vascular endothelial growth factor (VEGF) was initially characterized by its activity on the vascular system. However, there is growing evidence indicating that VEGF also acts as a neuroprotective factor, and administration to neurons suffering from trauma or disease able rescue them cell death. We questioned whether could maintain damaged in neurotransmissive mode evaluating synthesis of their neurotransmitter, action would be direct through well-known angiogenic activity. Adult rat...
Recent studies show a relationship between the deficit of vascular endothelial growth factor (VEGF) and motoneuronal degeneration, such as that occurring in amyotrophic lateral sclerosis (ALS). VEGF delivery protects motoneurons from cell death delayed neurodegeneration animal models ALS. Strikingly, extraocular lesser vulnerability to ALS compared other cranial or spinal motoneurons. Therefore, present study investigates possible differences its main receptor VEGFR-2 Flk-1 non-extraocular...