A5101493737- Mesenchymal stem cell research
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Autophagy in Disease and Therapy
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Various Chemistry Research Topics
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Tumors and Oncological Cases
- Dysphagia Assessment and Management
- Vitamin D Research Studies
- MicroRNA in disease regulation
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Airway Management and Intubation Techniques
- Gastrointestinal disorders and treatments
- Neurogenesis and neuroplasticity mechanisms
- Ear and Head Tumors
- Tissue Engineering and Regenerative Medicine
- Alzheimer's disease research and treatments
- Circular RNAs in diseases
- Inorganic and Organometallic Chemistry
Medical University of South Carolina
2003-2025
Ralph H. Johnson VA Medical Center
2021-2024
Augusta University
2010-2022
Augusta University Health
2010-2022
Charlie Norwood VA Medical Center
2011-2022
Iowa City Public Library
2022
American College of Clinical Pharmacy
2022
University of North Carolina at Pembroke
2022
Georgia Regents Medical Center
2013-2015
Boise VA Medical Center
2004-2014
The chemokine stromal-derived factor-1 (SDF-1, also known as CXCL12) and its receptor CXCR4 have been implicated in homing of stem cells to the bone marrow marrow-derived sites injury. Bone infiltrate brain give rise long-term resident following Therefore, SDF-1 expression patterns 40 mice were examined relative ischemic injury using a stroke model. Mice received transplants from green fluorescent protein (GFP) transgenic donors later underwent temporary middle cerebral artery suture...
Microvesicle- and exosome-mediated transport of microRNAs (miRNAs) represents a novel cellular molecular pathway for cell-cell communication. In this study, we tested the hypothesis that these extracellular vesicles (EVs) their miRNAs might change with age, contributing to age-related stem cell dysfunction. EVs were isolated from bone marrow interstitial fluid (supernatant) young (3-4 months) aged (24-28 mice determine whether size, concentration, miRNA profile altered age in vivo. Results...
Background and Purpose — After an ischemic event, bone marrow–derived cells may be involved in reparative processes. There is increasing evidence that stem a source of endothelial organ-specific cells. Our objectives were to determine whether neurons after cerebral ischemia. Methods We transplanted marrow from male C57 BL/6-TgN (ACTbEGFP)1Osb mice, which express green fluorescent protein (GFP), into female BL/6J mice. The recipient mice then underwent suture occlusion the middle artery...
Robust neuroprotective effects have been shown for minocycline. Whether it also protects nonneuronal cells or tissues is unknown. More importantly, the mechanisms of minocycline protection appear multifaceted and remain to be clarified. Here we show that can protect kidney epithelial in vitro kidneys from ischemic injury vivo. We further Bcl-2 a key molecular determinant protection. Minocycline protected against apoptosis induced by hypoxia, azide, cisplatin, staurosporine. The occurred at...
We previously reported increased monocyte/macrophage infiltration, reactive oxygen species accumulation, and nuclear factor-κB (NF-κB) activation in mineralocorticoid (deoxycorticosterone acetate [DOCA]) hypertensive rats. tested the hypothesis that prolonged antioxidant administration inhibits superoxide lowers blood pressure, reduces NF-κB DOCA-salt DOCA rats exhibited a significant increase systolic pressure compared with sham Aortic rings from (O 2 − ) production In addition, treatment...
Minocycline, a semi-synthetic tetracycline antibiotic, is an effective neuroprotective agent in animal models of cerebral ischemia when given high doses intraperitoneally. The aim this study was to determine if minocycline at reducing infarct size Temporary Middle Cerebral Artery Occlusion model (TMCAO) lower intravenous (IV) that correspond human clinical exposure regimens.Rats underwent 90 minutes TMCAO. Minocycline or saline placebo administered IV starting 4, 5, 6 hours post Infarct...
Abstract Subcortical Lewy bodies are the pathological hallmark of idiopathic Parkinson's disease. This study sought to determine extent which each neurofilament subunit [low (NF‐L), mid (NF‐M), or high (NF‐H)] was present in by using light, confocal, and electron microscopy. A battery 37 antineurofilament antibodies, characterized as specificity, epitope domain, phosphorylation status, employed probe substantia nigra from 15 disease cases. All antibodies labelled bodies. The epitopes...
AbstractIn recent studies, we and others showed that autophagy is critical to estrogen receptor positive (ER+) breast cancer cell survival the development of antiestrogen resistance. Consequently, new approaches are warranted for targeting in cells undergoing therapy. Because crosstalk has been demonstrated between autophagy- proteasome-mediated pathways protein degradation, this study investigated how proteasome inhibitor bortezomib affects antiestrogen-treated ER+ cells. Bortezomib, at...
Granulocyte colony-stimulating factor (G-CSF) is renoprotective during acute kidney injury (AKI) induced by ischemia and cisplatin nephrotoxicity; however, the underlying mechanism not entirely clear. Rhabdomyolysis another important clinical cause of AKI, due to release nephrotoxins (e.g., heme) from disrupted muscles. The current study has determined effects G-CSF on rhabdomyolysis-associated AKI using in vivo vitro models. In C57BL/6 mice, intramuscular injection glycerol which was...
Leptin receptors are abundant in human skeletal muscle, but the role of leptin muscle growth, development and aging is not well understood. Here we utilized a novel mouse model lacking all functional receptor isoforms (POUND mouse, Lepr(db/lb)) to determine muscle.Skeletal mass fiber diameters were examined POUND mice, primary myoblast cultures used effects altered signaling on proliferation differentiation. ELISA assays, integrated pathway analysis mRNA microarrays, reverse phase protein...
Abstract Lewy bodies are filamentous neuronal inclusions characteristic of Parkinson's disease, and neurofilament triplet proteins the major components filaments in bodies. Since found abnormally phosphorylated partially degraded, formation may be due to defective metabolism these proteins, this could lead impairments structure function rich processes (i.e., large caliber axons). To gain further insights into neurofilaments we evaluated mRNA levels by semiquantitative situ hybridization...
After ischemic stroke, hypertension increases the risk of recurrence, hemorrhage and fatal cerebral edema, but blood pressure (BP) lowering in acute stroke period is controversial due to fears infarct extension worsened outcomes.To determine whether BP with candesartan, initiated at reperfusion, can reduce neurovascular damage improve outcome a model after experimental stroke.Male Wistar rats (280-305 g) underwent 3 h middle artery occlusion (MCAO). At either saline (n = 18) or candesartan 1...
Abstract Background Mechanisms that affect recovery from fetal and neonatal hypoxic-ischemic (H-I) brain injury have not been fully elucidated. The incidence of intrapartum asphyxia is approximately 2.5%, but the occurrence adverse clinical outcome much lower. One factors which may account for this relatively good process neurogenesis, has described in adult animals. We used a mouse model to assess new cells hippocampus after H-I injury. Results Neonatal mice underwent permanent unilateral...
Antibiotic-induced shifts in the indigenous gut microbiota influence normal skeletal maturation. Current theory implies that actions on bone occur through a direct gut/bone signaling axis. However, our prior work supports gut/liver axis contributes to effects bone. Our purpose was investigate of minocycline, systemic antibiotic treatment for adolescent acne, pubertal/postpubertal Sex-matched specific pathogen-free (SPF) and germ-free (GF) C57BL/6T mice were administered clinically relevant...