A5044796983- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Gene Regulatory Network Analysis
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Neonatal and fetal brain pathology
- Early Childhood Education and Development
- S100 Proteins and Annexins
- Process Optimization and Integration
University of California, Irvine
2019-2024
Rockefeller University
2019
Several mental illnesses, characterized by aberrant stress reactivity, often arise after early-life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit maturation, provoking these enduring vulnerabilities. We find that increases functional excitatory synapses onto stress-sensitive hypothalamic corticotropin-releasing hormone (CRH)-expressing neurons, resulting from disrupted developmental synapse pruning adjacent microglia. Microglial process dynamics and...
Genetic polymorphisms of the L-type voltage-gated calcium channel (VGCC) are associated with psychiatric disorders including major depressive disorder. Alterations S100A10 (p11) level also implicated in etiology However, existence an endogenous regulator brain regulating p11, VGCC, and behavior has not been known. Here we report that Ahnak, whose function obscure, stabilizes p11 Anxa2 proteins hippocampus prefrontal cortex rodent brain. Protein levels highly positively correlated Together...
Early-life adversity (ELA) is associated with increased risk for mood disorders, including depression and substance use disorders. These disorders are characterized by impaired reward-related behaviors, suggesting compromised operations of brain circuits. However, the regions engaged ELA that mediate these enduring consequences remain largely unknown. In an animal model ELA, we identified aberrant reward-seeking a discovery provides framework assessing underlying circuits.Employing TRAP2...
Abstract Early-life adversity increases risk for mental illnesses including depression and substance use disorders, disorders characterized by dysregulated reward behaviors. However, the mechanisms which transient ELA enduringly impacts circuitries are not well understood. In mice, leads to anhedonia-like behaviors in males augmented motivation palatable food sex-reward cues females. Here, of genetic tagging demonstrated robust, preferential, sex-specific activation paraventricular nucleus...
Abstract The developmental origins of stress-related mental illnesses are well-established, and early-life stress/adversity (ELA) is an important risk factor. However, it unclear how ELA impacts the maturation salient brain circuits, provoking enduring vulnerability to stress disorders. Here we find that increases number function excitatory synapses onto stress-sensitive hypothalamic corticotropin-releasing hormone (CRH)-expressing neurons, implicate disrupted synapse pruning by microglia as...
Abstract Background Early-life adversity (ELA) is associated with increased risk for mood disorders including depression and substance use disorders. These are characterized by impaired reward-related behaviors, suggesting compromised operations of brain circuits. However, the regions engaged ELA that mediate these enduring consequences remain largely unknown. In an animal model ELA, we have identified aberrant reward-seeking a discovery provides framework assessing underlying Methods...