A5003423371- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Magnesium in Health and Disease
- Dialysis and Renal Disease Management
- Bone health and treatments
- Bone health and osteoporosis research
- Thyroid and Parathyroid Surgery
- Medical Imaging and Pathology Studies
- Pharmacological Effects and Toxicity Studies
- Genetic Syndromes and Imprinting
- Electrolyte and hormonal disorders
- Potassium and Related Disorders
- Trace Elements in Health
- Bone and Joint Diseases
- Pancreatitis Pathology and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Dermatological and Skeletal Disorders
- Neurological and metabolic disorders
- Vitamin C and Antioxidants Research
- COVID-19 and healthcare impacts
- Iron Metabolism and Disorders
- Membrane-based Ion Separation Techniques
- Renal Diseases and Glomerulopathies
- Heart Failure Treatment and Management
- Renal function and acid-base balance
Hospital de São João
2015-2025
Universidade do Porto
2015-2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2016-2024
Hospital da Senhora da Oliveira Guimarães
2024
Hospital Prof. Dr. Fernando Fonseca
2024
National Statistical Institute of Portugal
2017-2023
Charité - Universitätsmedizin Berlin
2022
Iscte – Instituto Universitário de Lisboa
2022
NIHR Birmingham Biomedical Research Centre
2021
University of Birmingham
2021
Disturbances in mineral metabolism play a central role the development of renal bone disease. In 54-wk, randomized, open-label study, 119 hemodialysis patients were enrolled to compare effects sevelamer hydrochloride and calcium carbonate on bone. Biopsy-proven adynamic disease was most frequent abnormality at baseline (59%). Serum phosphorus, calcium, intact parathyroid hormone well controlled both groups, although consistently lower higher among who randomly assigned sevelamer. Compared...
Background and objectives: There is increasing evidence that altered bone metabolism associated with cardiovascular calcifications in patients stage 5 chronic kidney disease on hemodialysis (HD). This study was conducted to evaluate the association between volume, turnover, coronary HD patients. Design, setting, participants, & measurements: In a cross-sectional study, biopsies multislice computed tomography were performed 38 Bone volume/total activation frequency, formation rate/bone...
Secondary hyperparathyroidism (SHPT) is associated with increased bone turnover, risk of fractures, vascular calcifications, and cardiovascular all-cause mortality. The classical treatment for SHPT includes active vitamin D compounds phosphate binders. However, achieving the optimal laboratory targets often difficult because sterols suppress parathyroid hormone (PTH) secretion, while also promoting calcium intestinal absorption. Calcimimetics increase sensitivity calcium-sensing receptor, so...
Calcimimetics decrease parathyroid hormone (PTH) secretion in patients with secondary hyperparathyroidism. The PTH should cause a reduction bone turnover; however, the direct effect of calcimimetics on cells, which express calcium-sensing receptor (CaSR), has not been defined. In this study, we evaluated effects CaSR activation by calcimimetic (AMG 641) vitro and vivo. To create "clamp," total parathyroidectomy was performed rats without uremia induced 5/6 nephrectomy, followed continuous...
Chronic kidney disease (CKD) is often associated with a mineral and bone disorder globally described as CKD-Mineral Bone Disease (MBD), including renal osteodystrophy, the latter ranging from high turnover, in case of secondary hyperparathyroidism (SHPT), to low turnover. The present article summarizes important subjects that were covered during 'The Parathyroid Day Kidney Disease' CME course organized Paris September 2017. It includes latest insights on parathyroid gland growth, hormone...
Disordered mineral and bone metabolism is a common complication of chronic kidney disease (CKD). Bone biopsy remains the gold standard tool for evaluating renal osteodystrophy (ROD), but it an invasive procedure. Despite growing interest in ability newer biomarkers to discriminate between different forms ROD, data on pre-dialysis patients are scarce.
Purpose: Bone biopsy is the only technique capable of comprehensively assessing all bone parameters, including turnover, microarchitecture, and mineralization, yet its clinical utility debated. This study evaluates role in routine diagnostic therapeutic applications. Methods: A retrospective analysis was conducted on 22 horizontal transiliac biopsies from 20 patients referred for rheumatology consultation between August 2016 May 2022. Diagnoses included osteoporosis, adynamic disease,...
Introduction Adults with end-stage kidney disease (ESKD) treated haemodialysis experience mortality of between 15% and 20% each year. Effective interventions that improve health outcomes for long-term dialysis patients remain unproven. Novel testable determinants in are needed. Nutrition dietary patterns potential factors influencing other settings warrant exploration multinational studies men women dialysis. We report the protocol “DIETary intake, death hospitalisation adults HaemoDialysis...
Women of all ages and elderly patients both genders comprise an increasing proportion the haemodialysis population. Worldwide, significant differences in practice patterns treatment results exist between among younger versus older patients. Although efforts to mitigate sex-based have been attempted, disparities still exist.This retrospective cohort study included 1247 prevalent DaVita units Portugal (five dialysis centres, n = 730) Poland (seven 517). Demographic data, patterns, vascular...