A5046456780- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- Neuroscience and Neural Engineering
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Cytomegalovirus and herpesvirus research
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Immune Cell Function and Interaction
- HIV Research and Treatment
- T-cell and B-cell Immunology
- HIV/AIDS drug development and treatment
Washington University in St. Louis
2019-2025
Ragon Institute of MGH, MIT and Harvard
2024
Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. To determine its role in pathogenesis, we generated mice with mutant alleles: an 8-nucleotide deletion that produces truncated, soluble form (Mxra8Δ8/Δ8) 97-nucleotide abolishes expression (Mxra8Δ97/Δ97). Mxra8Δ8/Δ8 Mxra8Δ97/Δ97 fibroblasts show reduced CHIKV infection culture, have decreased of musculoskeletal tissues CHIKV,...
CHIKV is a reemerging mosquito-transmitted virus that in the last decade has spread into Europe, Asia, Pacific Region, and Americas. Joint pain, swelling, stiffness can endure for months to years after infection, epidemics have severe economic impact. Elucidating mechanisms by which subverts antiviral immunity establish maintain persistent infection may lead development of new therapeutic strategies against chronic disease. In this study, we found establishes maintains joint-associated...
Priming CD8+ T cells against tumors or viral pathogens results largely from cross-presentation of exogenous antigens by type 1 conventional dendritic (cDC1s). Although monocyte-derived DCs and cDC2s can cross-present in vitro, their physiological relevance remains unclear. Here, we used genetic models to evaluate the role cDC subsets presentation cell-associated immune complex CD4+ vivo. For antigens, cDC1s were necessary sufficient prime both cells. In contrast, for either cDC1 cDC2, but...
Ross River virus (RRV) and other alphaviruses cause chronic musculoskeletal syndromes that are associated with viral persistence, which suggests deficits in immune clearance mechanisms, including CD8
Broadly neutralizing antibodies (bNAbs) have shown great promise for prevention and treatment of HIV infection. Breadth bNAb neutralization, measured
Abstract Arthritogenic alphaviruses have infected millions of people globally. Following acute infection, symptoms joint pain, swelling, and stiffness can last for months or even years, likely due to persistence viral RNA antigen, which also is seen in mice. Intriguingly, wild-type CD8−/− mice show a similar lack clearance RNA. Despite this, mechanism this CD8+ T cell evasion has not been identified. We hypothesized that there are defects the generation, function, migration cells after...