A5059609281- Single-cell and spatial transcriptomics
- Immune cells in cancer
- T-cell and B-cell Immunology
- Bioinformatics and Genomic Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Sarcoidosis and Beryllium Toxicity Research
- Gene Regulatory Network Analysis
- Molecular Biology Techniques and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- RNA modifications and cancer
- Chemokine receptors and signaling
- Occupational exposure and asthma
- Bacterial Genetics and Biotechnology
- Animal Genetics and Reproduction
- Chromosomal and Genetic Variations
- Genetic Associations and Epidemiology
- Gene expression and cancer classification
- RNA and protein synthesis mechanisms
Neurological Research Institute
2025
Baylor College of Medicine
2021-2025
Texas Children's Hospital
2025
Beijing Institute of Genomics
2016
Chinese Academy of Sciences
2016
Sichuan University
2013-2015
Chengdu University
2013
Craniofacial microsomia (CFM) is a rare congenital anomaly that involves immature derivatives from the first and second pharyngeal arches. The genetic pathogenesis of CFM still unclear. Here we interrogate 0.9 million variants in 939 cases 2,012 controls China. After genotyping an additional 443 1,669 controls, identify 8 significantly associated loci with most significant SNP rs13089920 (logistic regression P=2.15 × 10(-120)) 5 suggestive loci. above 13 loci, harboured by candidates ROBO1,...
Abstract INTRODUCTION Physical exercise is a primary defense against age‐related cognitive decline and Alzheimer's disease (AD). METHODS We conducted single‐nucleus transcriptomic chromatin accessibility analyses (snRNA‐seq snATAC‐seq) on the hippocampus of mice carrying mutations in amyloid precursor protein gene (APP NL‐G‐F ) following prolonged voluntary wheel‐running exercise. RESULTS Exercise mitigates amyloid‐induced changes transcriptome through cell type–specific regulatory networks...
Spatial transcriptomics, situated at the intersection of genomics and spatial biology, offers profound insights into organization gene expression within tissues. However, its potential has been constrained by either limited resolution or throughput. While single-cell RNA-seq allows for in-depth profiling cellular expression, crucial information is often sacrificed during sample collection. In a groundbreaking fusion these two techniques, our research introduces glmSMA computational...
Spatial transcriptomics, situated at the intersection of genomics and spatial biology, offers profound insights into organization gene expression within tissues. However, its potential has been constrained by either limited resolution or throughput. While single-cell RNA-seq allows for in-depth profiling cellular expression, crucial information is often sacrificed during sample collection. In a groundbreaking fusion these two techniques, our research introduces glmSMA computational...
The prokaryotic pangenome partitions genes into core and dispensable genes. order of genes, albeit assumed to be stable under selection in general, is frequently interrupted by horizontal gene transfer rearrangement, but how a core-gene-defined genome maintains its stability or flexibility remains investigated. Based on data from 30 species, including 425 genomes six phyla, we grouped syntenic blocks the context according their across multiple isolates. A subset often species specific...
Physical exercise represents a primary defense against age-related cognitive decline and neurodegenerative disorders like Alzheimer's disease (AD). To impartially investigate the underlying mechanisms, we conducted single-nucleus transcriptomic chromatin accessibility analyses (snRNA-seq ATAC-seq) on hippocampus of mice carrying AD-linked NL-G-F mutations in amyloid precursor protein gene (APP
Spatial transcriptomics, situated at the intersection of genomics and spatial biology, offers profound insights into organization gene expression within tissues. However, its potential has been constrained by either limited resolution or throughput. While single-cell RNA-seq allows for in-depth profiling cellular expression, crucial information is often sacrificed during sample collection. In a groundbreaking fusion these two techniques, our research introduces glmSMA computational...
Abstract Spatial gene-expression is a crucial determinant of cell fate and behavior. Recent imaging sequencing-technology advancements have enabled scientists to develop new tools that use spatial information measure at close single-cell levels. Yet, while Fluorescence In-situ Hybridization (FISH) can quantify transcript numbers resolution, it limited small number genes. Similarly, slide-seq was designed spatial-expression profiles the level but has relatively low gene-capture rate. And...
Abstract Spatial gene-expression is a crucial determinant of cell fate and behavior. Recent imaging sequencing-technology advancements have enabled scientists to develop new tools that use spatial information measure at close single-cell levels. Yet, while Fluorescence In-situ Hybridization (FISH) can quantify transcript numbers resolution, it limited small number genes. Similarly, slide-seq was designed spatial-expression profiles the level but has relatively low gene-capture rate. And...