A5046001540- Political and Social Dynamics in Chile and Latin America
- Laser-Plasma Interactions and Diagnostics
- Ion Transport and Channel Regulation
- Plasma Diagnostics and Applications
- Physiological and biochemical adaptations
- Nuclear Physics and Applications
- Organ Donation and Transplantation
- Laser-induced spectroscopy and plasma
- Renal Transplantation Outcomes and Treatments
- Atomic and Molecular Physics
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Neurobiology and Insect Physiology Research
- Ion-surface interactions and analysis
- Cellular transport and secretion
- Electrolyte and hormonal disorders
- Organ Transplantation Techniques and Outcomes
- Receptor Mechanisms and Signaling
- Chronic Kidney Disease and Diabetes
- Nitric Oxide and Endothelin Effects
- Antimicrobial Peptides and Activities
- Renal and Vascular Pathologies
- Drug Transport and Resistance Mechanisms
- Neuropeptides and Animal Physiology
- Renal function and acid-base balance
Temple University
2001-2024
Mount Desert Island Biological Laboratory
1982-2024
Advanced Center for Chronic Diseases
2018-2024
University of Chile
2015-2024
Millennium Institute on Immunology and Immunotherapy
2023-2024
Leiden University
2002-2022
Universidad de Londres
2022
University of Cologne
2022
Tulane University
2022
Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde
2022
Injections of radiocontrast agents are a frequent cause acute decreases in renal function, occurring most often patients with chronic insufficiency and diabetes mellitus.
We studied the role of catecholamines in regulation potassium homeostasis nine healthy subjects given intravenous chloride (0.5 meq per kilogram body weight) presence and absence propranolol. Potassium infusion elevated serum 0.6±0.09 liter (mean ±S.E.M.). Addition propranolol augmented rise (0.9±0.05 liter) prolonged elevation without decreasing urinary excretion. In a separate study, same load was administered with concomitant epinephrine five subjects. Epinephrine markedly blunted...
During the last 25 years Chilean society has experienced profound socioeconomic, political and even cultural changes. From 1964 to 1970 there was a ‘revolution in liberty’ under Eduardo Frei, from ‘Chilean road socialism’ Salvador Allende, 1973 1989 ‘silent revolution’ Augusto Pinochet.
Abstract Ouabain circulating in blood inhibits Na‐K‐ATPase the gills of seawater eels at a concentration similar to that necessary for inhibition vitro. By contrast, much higher is required when ouabain applied exterior gill. Inhibition by external occurs only drug gains access circulation fish, as evidenced simultaneous kidney. These results suggest gill chloride cells faces inward, lining intracytoplasmic tubular channels continuous with extracellular fluid. intact salt water almost...
Plasma potassium rises during muscular exercise and falls rapidly when is stopped. Since the sympathoadrenal system stimulated with exertion both α- β-adrenergic agonists affect internal homeostasis, we studied influence of catecholamines on shifts after exercise. Six healthy subjects were given maximal stress tests under three conditions: no medication (control), β-blockade propranolol, α-blockade phentolamine. Compared a peak rise in plasma 1.23±0.27 mmol per liter (mean ±S.E.M.) control...
The neutron emission from a small and fast plasma focus operating in deuterium is presented. system operates at low energy the hundred of joules range (880 nF capacitor bank, 38 nH, 20–35 kV, 176–539 J, ∼300 ns current rise time). neutrons were measured by means silver activation counter, total yield versus gas filling pressure was obtained. For discharges 30 kV charging voltage, maximum (1.06±0.13)×106 per shot 9 mbar.
Elevated testosterone concentrations induce cardiac hypertrophy but the molecular mechanisms are poorly understood. Anabolic properties of involve an increase in protein synthesis. The mammalian target rapamycin complex 1 (mTORC1) pathway is a major regulator cell growth, relationship between action and mTORC1 cells remains unknown. Here, we investigated whether hypertrophic effects mediated by signaling cultured cardiomyocytes. Testosterone increases phosphorylation mTOR its downstream...
The specific activity of sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) in homogenates rat kidneys increases when the dietary intake potassium is chronically increased. effect seen first and most prominent outer medulla, but large loads elicit an increase cortex as well. Levels Na-K-ATPase brian, liver, muscle, by contrast, are unaffected loading. Although changes enzyme kidney resemble those reportedly produced aldosterone, they not induced experimental sodium...
Saliva is a key factor that contributes to the high efficiency of wound healing in oral mucosa. This not only attributed physical cues but also presence specific peptides saliva, such as histatins. Histatin-1 38 aa antimicrobial peptide, highly enriched human which has been previously reported promote migration keratinocytes and fibroblasts vitro. However, participation histatin-1 other crucial events required for healing, angiogenesis, unknown. Here we demonstrate promotes shown vivo, using...
Polyene antibiotics such as amphotericin and nystatin increase membrane permeability thus the amount of oxygen consumed in active electrolyte transport. In isolated perfused rat kidneys, polyenes produced extensive injury to medullary thick ascending limb, a segment nephron with limited supply. This damage was prevented if reabsorptive transport inhibited by ouabain. Cell death under these circumstances appears be mediated increased demand for activity.
Neutron emission from a deuterium plasma pinch generated in very small focus (6 mm anode diameter) operating at only tens of joules is presented. A maximum current 50 kA achieved 140 ns after the beginning discharge, when device charged J (160 nF capacitor bank, 38 nH, 20–30 kV, 32–72 J). Although stored energy low, estimated density and per particle are same order as higher devices. The dependence neutron yield on filling pressure was obtained for discharges with 67 bank. Neutrons were...
Since β-adrenergic stimulation enhances extrarenal potassium uptake, we postulated an opposite effect of the α-adrenergic nervous system. Seven healthy subjects were given intravenous chloride (0.5 mmol per kilogram body weight), in presence and absence α-agonist phenylephrine. After alone, level rose to 0.64±0.03 (mean ±S.E.M.); phenylephrine augmented rise (0.93±0.09 mmol, P<0.025) prolonged it, without changing urinary excretion. Subsequent administration together with α-antagonist...
Background and objectives Living donor kidney transplantation, the treatment of choice for ESRD, is underused by women blacks. To better understand sex differences in context potential barriers to living Dialysis Patient Transplant Questionnaire was administered two urban, predominantly black hemodialysis units. Design, setting, participants, & measurements The designed study transplantation from previously validated questions. Between July 2008 January 2009, 116 patients on hemodialysis,...
// Patricio Silva 1 , Pablo Mendoza Solange Rivas Jorge Díaz Carolina Moraga Andrew F.G. Quest 2, 3 Vicente A. Torres 1, 2 Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile Advanced Center Chronic Diseases (ACCDiS), Medicine, Molecular Studies the Cell (CEMC) and Program Biology, Biomedical Correspondence to: Torres, e-mail: vatorres@med.uchile.cl Keywords: Rab5, hypoxia, migration, metastasis, tumor Received: November 10,...
Abstract Active transport of chloride in the salt secreting rectal gland dogfish Squalus acanthias is markedly stimulated by addition theophylline (0.01 to 5 mM) or dibutyryl cyclic AMP (0.05 during vitro perfusion. The effect occurs promptly and may persist for two hours. Specific hormonal effectors have not yet been identified. isolated perfused thus offers a unique opportunity examine cellular mechanisms active secretion.
High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding HFD increases the concentration of saturated fatty acid palmitic (PA) in hypothalamus. We previously showed that, hypothalamic neuronal cells, exposure to PA inhibits autophagic flux, which whole process from synthesis autophagosomes, up their lysosomal fusion and degradation. However, mechanism by impairs autophagy neurons remains unknown. Here, we show that PA-mediated reduction flux not caused...
Abstract Background Testosterone regulates nutrient and energy balance to maintain protein synthesis metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined that testosterone increased glucose uptake—via AMP-activated kinase (AMPK)—after acute treatment cardiomyocytes. However, whether elevated uptake is involved long-term changes of or required during cardiomyocyte growth remained unknown. In this study, hypothesized...