A5033044099- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Prostate Cancer Diagnosis and Treatment
- DNA Repair Mechanisms
- Drug Transport and Resistance Mechanisms
- Genetics and Neurodevelopmental Disorders
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Reproductive System and Pregnancy
- Cardiomyopathy and Myosin Studies
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Pregnancy and Medication Impact
- Cancer Mechanisms and Therapy
- Prenatal Screening and Diagnostics
- Memory and Neural Mechanisms
- Pregnancy and preeclampsia studies
- Olfactory and Sensory Function Studies
- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Biopolymer Synthesis and Applications
- Pulmonary Hypertension Research and Treatments
Qingdao University
2010-2024
Qingdao Municipal Hospital
2010-2024
Kaiser Permanente Sacramento Medical Center
2020
The University of Texas Southwestern Medical Center
2019
Ghrelin is an orexigenic brain-gut hormone promoting feeding and regulating energy metabolism in human rodents. An increasing number of studies have reported that ghrelin its identified receptor, the growth secretagogue receptor 1a (GHS-R1a), produces remarkably wide complex functions biological effects on specific populations neurons central nervous system. In this study, we sought to explore vivo acute exposure lateral amygdala (LA) at physiological behavioral levels. extracellular...
Abstract Aim Active changes in neuronal DNA methylation and demethylation appear to act as controllers of synaptic scaling glutamate receptor trafficking learning memory formation. methyltransferases (DNMTs), including proteins encoded by Dnmt1 , Dnmt3a Dnmt3b are dominant enzymes carrying out methylation. Our previous study demonstrated the important roles that DNMT1 DNMT3a play function memory. In this study, we aim explore role DNMT3b its-mediated processes. Methods was knocked down...
Abstract Background Increasing evidence has been confirmed that small nucleolar RNAs (SnoRNAs) play critical roles in tumorigenesis and exhibit prognostic value clinical practice. However, there is short of systematic research on SnoRNAs ovarian cancer (OV). Material/Methods 379 OV patients with RNA‐Seq parameters from TCGA database 5 paired tissues were embedded our study. Cox regression analysis was used to identify construct prediction model. SNORic adopted examine the copy number...
The aim of the present study was to investigate expression pattern four DNA methyltransferases (DNMT1, DNMT3A, DNMT3B and DNMT3L) in placenta chorionic villi early embryo growth arrest patients. Chorionic villous specimens were obtained from 40 pregnant patients diagnosed with healthy women who underwent selective pregnancy termination. Reverse transcription‑quantitative polymerase chain reaction, immunohistochemistry western blot analysis performed characterize mRNA protein DNMTs cells. It...
The aim of the present study was to investigate protein expression profiling pregnane X receptor (PXR) and ATP-binding cassette sub-family B member 1 (ABCB1; also known as MDR1 or P-gp), in peripheral blood mononuclear cells (PBMCs) cancerous tissues cases non-small cell lung cancer (NSCLC). Furthermore, aimed assess feasibility predicting drug resistance through medium PBMCs. Of subjects included study, 37 were histopathologically diagnosed with NSCLC 17 control patients without cancer....
MFAP2 has been reported to play an oncogenic role in several types of human cancers. However, the expression profile various cancers and its impact on prognosis immune infiltration remain unclear. In this study, mRNA protein normal tissues, tumor cell lines, 33 malignant tissues were analyzed comprehensively using Genotype-Tissue Expression (GTEx), Cancer Cell Line Encyclopedia (CCLE), The Genome Atlas (TCGA), Oncomine UALCAN databases, different grades stages was assessed Gene Profiling...
Squamous differentiation of prostate cancer, which accounts for less than 1% all cases, is typically associated with androgen deprivation treatment (ADT) or radiotherapy. This entity aggressive and exhibits poor prognosis due to limited response traditional treatment. However, the underlying molecular mechanisms etiology are not fully understood. Previous findings suggest that squamous cell may potentially arise from adenocarcinoma (AC), but further validation required confirm this...
Transmembrane protein 16A was involved in the development of monocrotaline-induced pulmonary arterial hypertension model through ERK1/2 activation, and it considered as potential target for treatment. A rat established by intraperitoneal administration monocrotaline. Noninvasive pulsed-wave Doppler histological analysis performed, revealed proliferation remodeling arterioles right ventricle hypertrophy. In addition, transmembrane 16A, proliferating cell nuclear antigen-a proliferate marker,...
Abstract Background: The challenge of expanding haematopoietic stem/progenitor cells (HSPCs) in vitro has limited the clinical application this technology. Human hair follicle mesenchymal stem (hHFMSCs) can be reprogrammed to generate intermediate by introducing only OCT4 (hHFMSCs ). Prestimulating these with a low concentration cytokines FLT3 and SCF leads generation distinct subset, named floating hHFMSCs , which maintain self-renewal induced undergo erythropoiesis, suggesting that are...
Abstract Background Reduced sensitivity to chemotherapeutic agents caused by multidrug resistance is the main obstacle in treatment of non-small cell lung cancer (NSCLC). Activated NF-κB/PXR pathway stimulated procytokine TNF-α implicated formation phenotype. However, underlying mechanisms are obscure, and results concluded various tumors conflicted. Herein, we explored effects on activation development NSCLC. Methods Cancerous tissues were used evaluate expression inflammatory stroma cells...
Abstract Background: Increasing evidence has been confirmed that small nucleolar RNAs (SnoRNAs) play critical roles in tumorigenesis and exhibit prognostic value clinical practice. However, there is short of systematic research on SnoRNAs ovarian cancer (OV). Material/methods: 379 OV patients with RNA-Seq parameters from TCGA database 5 paired tissues were embedded our study. Cox regression analysis was used to identify construct prediction model. SNORic adopted examine the copy number...