A5073063749- Protein Interaction Studies and Fluorescence Analysis
- Metal complexes synthesis and properties
- Lanthanide and Transition Metal Complexes
- Bee Products Chemical Analysis
- Medicinal plant effects and applications
- Genetic factors in colorectal cancer
- Phagocytosis and Immune Regulation
- Insect Utilization and Effects
- Healthcare and Venom Research
- Drug Transport and Resistance Mechanisms
- Cell death mechanisms and regulation
- Colorectal Cancer Treatments and Studies
- Nanoparticle-Based Drug Delivery
- Phytochemical and Pharmacological Studies
- Pharmacological Effects of Natural Compounds
- Medicinal Plant Research
- Phytochemicals and Medicinal Plants
- Phytochemical compounds biological activities
- Gastric Cancer Management and Outcomes
- Insect Pest Control Strategies
- Essential Oils and Antimicrobial Activity
University of Kragujevac
2022-2025
Background/Objectives: Multidrug resistance is one the leading problems in cancer treatment, where overexpression of P-gp and other drug efflux pumps regarded as primary cause. With intention to develop transporter inhibitors, natural products such phenolics have shown great potential diverse attention recently. Among these, isorhamnetin (ISO), an O-methylated flavonol, predominantly found fruits leaves various plants. Thus, this study aimed investigate effects ISO on mRNA expression...
In this study, the anticancer effect of Melittin was demonstrated through its antiproliferative and proapoptotic effects on HT-29 cells, as well ability to reverse multidrug resistance. directly affects death receptor-dependent apoptotic pathway via increase Fas receptor protein expression, Caspase 8 gene expression activity 8. Results decreased 9 multi-fold increased Bcl-2 suggest that mitochondria inner are not involved in execution induced apoptosis, redox regulation apoptosis based...
Abstract With the aim to reveal antitumor drug which possesses improved activity compared with cisplatin, we synthesized new dinuclear gold(III) complex 1,5-naphthyridine as bridging ligand. Further, newly was characterized by various techniques confirm structure. The stability of this in water and PBS buffer investigated UV-Vis spectroscopy. DNA binding studies were examined UV-Vis, fluorescence spectroscopy viscosity measurements. competitive EB or HOE done results showed that interacts...
The insect silk protects the larvae that produce it. This implies it may contain biologically active substances can be used in medicine. In this paper, cytotoxic and proapoptotic potential of Indian meal moth (Plodia interpunctella) extract was examined after 72 h exposure to SW-480 human colorectal adenocarcinoma cell line. Apoptosis by monitoring morphological changes fluorescent staining, acridine orange/ethidium bromide, DAPI, as well flow cytometry. results showed has a very good...
Medicinal plants have widely been used as a natural source of remedies for treating several diseases, including colorectal cancer. Ocimum minimum L. is very important dietary plant in traditional and modern medicine, due to its health beneficial effect realized by cytotoxic, proapoptotic, antioxidant/prooxidant, antiviral antimicrobial activity. The biological activity O. flowers has evaluated HCT116 carcinoma cells through antiproliferative MTT assay, pro-apoptotic AO/EB concentrations...