A5016394431- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Nerve injury and regeneration
Universitätsklinikum Würzburg
2023
Axon degeneration and functional decline in myelin diseases are often attributed to loss of but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation contribute demyelination axonal damage. Here we study mice with distinct defects the proteolipid protein 1 gene that develop damage which driven by cytotoxic T cells targeting oligodendrocytes. We show persistent ensheathment perturbed poses a risk for axon degeneration, neuron loss,...
Myelin defects lead to neurological dysfunction in various diseases and normal aging. Chronic neuroinflammation often contributes axon-myelin damage these conditions can be initiated and/or sustained by perturbed myelinating glia. We have previously shown that distinct
Abstract Axon degeneration and functional decline in myelin diseases are often attributed to loss of but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation contribute demyelination axonal damage. Here we study mice with distinct defects the proteolipid protein 1 gene that develop damage which driven by cytotoxic T cells targeting oligodendrocytes. We show persistent ensheathment perturbed poses a risk for axon degeneration, neuron loss,...
Summary Myelin defects lead to neurological dysfunction in various diseases and normal aging. Chronic neuroinflammation often contributes axon-myelin damage these conditions can be initiated and/or sustained by perturbed myelinating glia. We have previously shown that distinct mutations the PLP1 gene result neurodegeneration is largely driven adaptive immune cells. Here we characterize CD8 + CNS-associated T cells myelin mutants using single-cell transcriptomics identify population...