A5050597052- Virus-based gene therapy research
- Surgical Simulation and Training
- RNA modifications and cancer
- Respiratory viral infections research
- Meningioma and schwannoma management
- Ear Surgery and Otitis Media
- Biochemical and Molecular Research
- Augmented Reality Applications
- Glaucoma and retinal disorders
- Advanced Radiotherapy Techniques
- Advanced Vision and Imaging
- Anatomy and Medical Technology
- Facial Nerve Paralysis Treatment and Research
- Tracheal and airway disorders
- Thyroid and Parathyroid Surgery
- Advanced Image Processing Techniques
- Corneal surgery and disorders
- Chronic Lymphocytic Leukemia Research
- Thyroid Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Anomalies
- Corneal Surgery and Treatments
- Acute Lymphoblastic Leukemia research
- Glioma Diagnosis and Treatment
- Radiation Dose and Imaging
Johns Hopkins Medicine
2019-2025
Johns Hopkins University
2019-2025
Oxford University Press (United Kingdom)
2020
University of California, San Francisco
2017
Hong Kong Sanatorium and Hospital
2015-2016
Stereo depth estimation relies on optimal correspondence matching between pixels epipolar lines in the left and right images to infer depth. In this work, we revisit problem from a sequence-to-sequence perspective replace cost volume construction with dense pixel using position information attention. This approach, named STereo TRansformer (STTR), has several advantages: It 1) relaxes limitation of fixed disparity range, 2) identifies occluded regions provides confidence estimates, 3)...
Abstract Objective Preoperative planning for otologic or neurotologic procedures often requires manual segmentation of relevant structures, which can be tedious and time‐consuming. Automated methods segmenting multiple geometrically complex structures not only streamline preoperative but also augment minimally invasive and/or robot‐assisted in this space. This study evaluates a state‐of‐the‐art deep learning pipeline semantic temporal bone anatomy. Study Design A descriptive network. Setting...
Abstract Objective To compare long‐term health‐related quality of life (HRQOL) after Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) and transcervical approach (TCA) thyroidectomy. Study Design Prospective cohort study. Setting Tertiary referral center. Methods A web‐based survey was distributed to patients at our institution who met the criteria for TOETVA underwent thyroidectomy by or TCA between August 2017 October 2021. All participants were least 6 months postsurgery....
Objective This study investigates the accuracy of an automated method to rapidly segment relevant temporal bone anatomy from cone beam computed tomography (CT) images. Implementation this segmentation pipeline has potential improve surgical safety and decrease operative time by augmenting preoperative planning interfacing with image‐guided robotic systems. Study Design Descriptive predicted segmentations. Setting Academic institution. Methods We have developed a computational based on...
Teprotumumab is a fully human IgG1 monoclonal antibody against insulin-like growth factor-1 receptor (IGF-1R). It has been approved by the FDA to treat thyroid eye disease (TED) reducing extraocular muscle and orbital fat volume. In clinical trials, hearing loss was noted as side effect in 7 12% of patients, but no formal audiometric investigations these patients were reported. Furthermore, manufacturer offer guidelines for monitoring. This case report first describe sensorineural (SNHL)...
Abstract Objective Inaccurate patient triage contributes to suboptimal clinical capacity management and delays in care, which cancer patients may significantly increase morbidity mortality. We developed a natural language processing (NLP) model as an adjunctive tool for head neck (H&N) workflows. This study assesses the model's ability categorize appointments based on available documentation. Study Design A retrospective cohort study. Setting An academic institution. Methods total of 83...
Background: Mandibular bilateral sagittal split osteotomy (BSSO) is a common procedure used in orthognathic surgery. The greatest complication of BSSO damage to the inferior alveolar nerve, resulting facial numbness and poor quality life. This study aimed create low-cost, biomechanically accurate 3D-printed mandible model for surgical training prevent such complications. Methods: A 3D was created from CT scans printed using 12 different resin mixtures. Biomechanical testing performed...
Surgical simulators not only allow planning and training of complex procedures, but also offer the ability to generate structured data for algorithm development, which may be applied in image-guided computer assisted interventions. While there have been efforts on either developing platforms surgeons or generation engines, these two features, our knowledge, offered together. We present developments a cost-effective synergistic framework, named Asynchronous Multibody Framework Plus (AMBF+),...
Abstract Nasopharyngeal carcinoma (NPC) is a squamous cell with proclivity for systemic dissemination, leading many patients to present advanced stage disease and fail available treatments. There notable lack of targeted therapies NPC, despite working knowledge multiple proteins integral roles in NPC cancer biology. These include EZH2, Snail, eIF4E, IMPDH, which are all overexpressed correlated poor prognosis. known be modulated by ribavirin, an FDA-approved hepatitis C antiviral that has...
The introduction of image-guided surgical navigation (IGSN) has greatly benefited technically demanding procedures by providing real-time support and guidance to the surgeon during surgery. To develop effective IGSN, a careful selection information medium present this is needed. However, not trivial task due broad array available options. address problem, we have developed an open-source library that facilitates development multimodal systems in wide range relying on medical imaging data....
Currently, no consensus exists as to whether patients who develop infection of the surgical site after undergoing instrumented fusion should have their implants removed at time wound debridement. Instrumentation removal may eliminate a potential nidus, but also destabilize patient's spine. The authors sought summarize existing evidence by systematically reviewing published studies that compare outcomes between washout and instrumentation with alone. primary objectives were determine 1) from...
Hypothesis Automated image registration techniques can successfully determine anatomical variation in human temporal bones with statistical shape modeling. Background There is a lack of knowledge about inter-patient the bone. Statistical models (SSMs) provide powerful method for quantifying structures medical images but are time-intensive to manually develop. This study presents SSMs bone anatomy using automated image-registration techniques. Methods Fifty-three cone-beam CTs were included...
Medulloblastoma, the most common pediatric brain malignancy, has Sonic Hedgehog (SHH) and group 3 (Myc driven) subtypes that are associated with activity of eukaryotic initiation factor 4E (eIF4E), a critical mediator translation, enhancer zeste homolog 2 (EZH2), histone methyltransferase master regulator transcription. Recent drug repurposing efforts in multiple solid hematologic malignancies have demonstrated eIF4E EZH2 both pharmacologically inhibited by FDA-approved antiviral ribavirin....
Objective Proposed methods of minimally invasive and robot‐assisted procedures within the temporal bone require measurements surgically relevant distances angles, which often time‐consuming manual segmentation preoperative imaging. This study aims to describe an automatic measurement extraction pipeline cone‐beam computed tomography (CT) scans. Study Design Descriptive measurements. Setting Academic institution. Methods A propagation template composed 16 CT scans was formed with anatomical...
Cochlear implants (CIs) are a well-established treatment modality for hearing loss due to neurofibromatosis type 2 (NF2). Our aim is investigate variables that affect longitudinal performance of CIs among patients with NF2.
Approximately 6% of adults eligible for cochlear implantation (CI) undergo surgery. This study aims to understand how general perceptions about CI contribute barriers causing this low utilization rate.Participants completed an online survey regarding their implantation. They were asked rank CIQOL-10 Global priorities and corresponding risk tolerance minor complications (changes in taste, vertigo) major (infections requiring hospitalization, meningitis, reimplantation, facial paralysis,...
Virtual fixtures can be enforced in cooperative-control robotic mastoidectomies with submillimeter accuracy.Otologic procedures are well-suited for assistance due to consistent osseous landmarks. We have previously demonstrated the feasibility of robots (CCRs) mastoidectomy. CCRs manipulate instruments simultaneously surgeon, allowing surgeon control augmentation motion. also enforce virtual fixtures, which safety barriers that prevent motion into undesired locations. Previous studies...
Atypical teratoid rhabdoid tumors (ATRTs) are aggressive pediatric brain with no current standard of care and an estimated median patient survival 12 to 18 months. Previous genetic analyses have implicated cyclin D1 enhancer zeste homolog 2 (EZH2), a histone methyltransferase that is in many cancers, as key drivers tumorigenicity ATRTs. Since the effects EZH2 facilitated by host cyclin-dependent kinases (CDKs), authors sought investigate potential therapeutic targeting CDKs ATRTs multi-CDK...