The clinical manifestations of nervous system involvement in systemic lupus erythematosus (neuropsychiatric SLE [NPSLE]) are highly diverse, and their etiology is incompletely understood. aim this study was to provide an inventory abnormalities on conventional brain magnetic resonance imaging (MRI) NPSLE interpret the findings relation possible underlying pathogenetic mechanisms.MR images first episode active 74 patients were retrospectively reviewed. All fulfilled American College...

Objectives. Neuropsychiatric (NP) involvement is a poorly understood manifestation of SLE. We studied post-mortem histopathology in relation to clinical NPSLE syndromes and complement deposition brains SLE patients controls. Furthermore, we investigated the correlation between cerebral ex vivo 7 T MRI findings NPSLE. Methods. A nationwide search for autopsy material yielded brain tissue from 16 18 patients. Brains obtained 24 who died acute cardiac events served as Apart histopathological...

<h3>Background</h3> Different pathogenetic pathways have been proposed for neuropsychiatric (NP) manifestations in systemic lupus erythematosus (SLE). <h3>Objective</h3> To describe the patient characteristics of a large cohort patients with SLE NP (NPSLE) single centre and to review whether these other data are compatible immune-mediated mechanisms. <h3>Methods</h3> A total 212 were identified from MRI scans brain ordered suspected NPSLE. Data collected medical records. syndromes classified...

Systemic lupus erythematosus is an inflammatory autoimmune disease with multi-organ involvement. Central nervous system involvement in systemic common and results several neurological psychiatric symptoms that are poorly linked to standard magnetic resonance imaging outcome. Magnetic methods sensitive tissue microstructural changes, such as diffusion tensor magnetization transfer imaging, show some correlation neuropsychiatric (NPSLE) symptoms. Histological examination of NPSLE brains...

To determine the 5-year outcomes of early remission induction therapy followed by targeted treatment aimed at drug-free (DFR) in patients with arthritis.In 12 hospitals, 610 (<2 years) rheumatoid arthritis (RA) or undifferentiated (UA) started on methotrexate (MTX) 25 mg/week and prednisone (60 mg/day tapered to 7.5 mg/day). Patients not (Disease Activity Score <1.6 after 4 months) were randomised (single blind) arm 1, adding hydroxychloroquine 400 sulfasalazine 2000 mg/day, 2, switching MTX...

Abstract Objective In patients with systemic lupus erythematosus (SLE) and nephritis, the presence of antiphospholipid antibodies (aPL) is considered to be an indication increased risk thrombotic microangiopathy, a serious complication SLE. Previous studies have demonstrated critical role for activation classical pathway complement that leads injury in aPL. This study was undertaken investigate whether C4d deposition nephritis related circulating aPL renal microthrombi. Methods Deposition...

To describe clinical phenotypes in neuropsychiatric systemic lupus erythematosus (NPSLE).Data were prospectively collected the Leiden NPSLE referral clinic, where patients suspected of having are assessed a standardized multidisciplinary manner. In consensus meetings, all medical specialists agreed on therapeutic strategy based pathogenetic mechanism individual patient. An algorithm illustrates process decision-making during meeting. Clinical described, classified by mechanism.One hundred...

To determine the contribution of reassessment in attribution process neuropsychiatric (NP) events to SLE or other aetiologies a large, prospective and multidisciplinary assessed NPSLE cohort compare these results with available models for NP occurring SLE. Three hundred four consecutive patients presenting were evaluated. All subjects underwent standardized medical, neuropsychological, laboratory radiological examination on inclusion dates. Diagnosis was always established by consensus. The...

Antibodies specifically affect the amygdala in a mouse model of systemic lupus erythematosus (SLE). The aim our study was to investigate whether there is also specific involvement human SLE.We analyzed group 37 patients with neuropsychiatric SLE (NP-SLE), 21 SLE, and 12 healthy control participants diffusion weighted imaging (DWI). In addition, subset eight patients, plasma available determine their anti-NMDAR antibody status. From structural magnetic resonance data, hippocampus were...

This study aims to examine the needs and preferences regarding delivery of health care services information provision their determinants in patients with systemic sclerosis (SSc). A questionnaire was sent 77 SSc outpatients, comprising 27 items on within domains physical, psychological, social support, employment/daily activities, or other problems 13 needs. Moreover, patients' were listed. Additional assessments included sociodemographic characteristics, physical functioning (SSc Health...

Articular manifestations are common in systemic lupus erythematosus (SLE) whereas erosive disease is not. Antibodies to cyclic citrullinated peptide (anti-CCP) citrulline-dependent rheumatoid arthritis (RA), the opposite suggested SLE, as reactivity with arginine (CAP) typically present. targeting carbamylated proteins (anti-CarP) may occur anti-CCP/rheumatoid factor (RF)-negative cases long before clinical onset of RA. We analysed these antibody specificities sera from European patients SLE...

C1q deficiency is a rare immunodeficiency, which strongly associated with the development of systemic lupus erythematosus (SLE). A mutation in one genes can either lead to complete or low levels polypeptide form low-molecular weight (LMW) C1q. Patients mainly present cutaneous and renal involvement. Although less frequent, neuropsychiatric (NP) involvement has also been reported 20% C1q-deficient patients. This appears be absent other deficiencies early components complement classical...

Objective Assess quality of life in patients with systemic lupus erythematosus (SLE) presenting neuropsychiatric symptoms (neuropsychiatric SLE, NPSLE). Methods Quality was assessed using the Short-Form 36 item Health Survey (SF-36) visiting Leiden NPSLE clinic at baseline and follow-up. SF-36 subscales summary scores were calculated compared general Dutch population other chronic diseases. Results At baseline, 248 SLE patients, whom 98 had (39.7%). Follow-up data available for 104 (42%), 64...

•In SLE patients, LV systolic function as measured by GLS is significantly impaired.•Impaired in patients associated with cardiovascular events.•Assessment of may improve risk-stratification patients. BackgroundSystemic lupus erythematosus (SLE) a chronic autoimmune disorder potential involvement. The aim this study was to assess left ventricular (LV) large cohort using standard echocardiographic measurements and global longitudinal strain (GLS) two-dimensional speckle-tracking analysis....

Abstract Background We present a study protocol for randomized, double-blind, placebo-controlled trial that investigates the hypothesis if intervention in symptomatic phase preceding clinical arthritis (clinically suspect arthralgia (CSA)) is effective preventing progression from subclinical inflammation to clinically apparent persistent arthritis. Currently, rheumatoid (RA) can be recognized and diagnosed when (joint swelling) has become detectable at physical examination. Importantly, this...

Introduction We aimed to investigate risk factors for fatigue in patients with systemic lupus erythematosus (SLE) and neuropsychiatric symptoms order identify potential interventional strategies. Methods Patients visiting the SLE (NPSLE) clinic of Leiden University Medical Center between 2007–2019 were included. In a multidisciplinary consensus meeting, classified as having inflammatory origin (inflammatory phenotype) or other (non-inflammatory phenotype). Fatigue was assessed SF-36 vitality...

The aim of this study was to determine whether there are differences in white matter integrity between systemic lupus erythematosus (SLE) patients and healthy controls, as determined using tract-based spatial statistics (TBSS) analysis diffusion tensor imaging data.Twelve with SLE (mean age 42 years [range 15-61 years]) diagnosed according the American College Rheumatology 1982 revised criteria for 28 controls 46 21-61 were included study. Magnetic resonance performed on a 3.0T scanner....

The objective of this paper is to analyse serum levels anti-C1q, C1q circulating immune complexes (CIC), complement activation and components in systemic lupus erythematosus (SLE) patients during the first central nervous system neuropsychiatric (NP) event define possible association between these results clinical laboratory characteristics.A total 280 suspected having NP involvement due SLE were recruited Leiden NPSLE-clinic. All classified according ACR 1982 revised criteria for...

Objective We aimed to evaluate all-cause and cause-specific mortality in patients with systemic lupus erythematosus (SLE) neuropsychiatric (NP) symptoms the Netherlands between 2007–2018. Methods Patients visiting tertiary referral NPSLE clinic of Leiden University Medical Center were included. NP attributed SLE requiring treatment (major NPSLE) or other mild causes (minor/non-NPSLE). Municipal registries checked for current status (alive/deceased). Standardized ratios (SMRs) 95% confidence...

Objective The effect of serum autoantibodies on the brain systemic lupus erythematosus (SLE) patients remains unclear. We investigated whether autoantibodies, individually and assessed in groups, are associated with specific brain-MRI abnormalities or these structural changes other SLE-related traditional cardiovascular disease risk factors. Methods All underwent 3Tesla-MRI. White matter hyperintensities (WMHs), ischemic lesions, inflammatory-like lesions cerebral atrophy were scored. Serum...