A5101879455- Near-Field Optical Microscopy
- Orbital Angular Momentum in Optics
- Metamaterials and Metasurfaces Applications
- Optical Coatings and Gratings
- Plasmonic and Surface Plasmon Research
- Force Microscopy Techniques and Applications
- Sperm and Testicular Function
- Silk-based biomaterials and applications
- Micro and Nano Robotics
- Supramolecular Self-Assembly in Materials
- Reproductive Biology and Fertility
- Biochemical and Structural Characterization
- Digital Holography and Microscopy
- Cellular Mechanics and Interactions
- Integrated Circuits and Semiconductor Failure Analysis
- Cerebrospinal fluid and hydrocephalus
- Hemoglobin structure and function
- Antimicrobial Peptides and Activities
- Diabetic Foot Ulcer Assessment and Management
- Blood properties and coagulation
- Characterization and Applications of Magnetic Nanoparticles
- Lipid Membrane Structure and Behavior
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Lymphatic System and Diseases
- Microfluidic and Bio-sensing Technologies
Chinese Academy of Sciences
2003-2025
National Center for Nanoscience and Technology
2012-2023
University of Chinese Academy of Sciences
2022-2023
Center for NanoScience
2022
Forschungszentrum Jülich
2005-2010
Heinrich Heine University Düsseldorf
2010
Institute of Theoretical Physics
2003-2005
Chinese Academy of Social Sciences
2004
Laminar blood flow represents the normal physiological state of circulation, but it also acts as a natural barrier for effective diffusion drugs to lesion site. Here, we report bioinspired strategy in which reconfigurable vortexlike swarms magnetic swimming nanobots actively disrupt laminar deliver manner similar how bacteria seek food. The drug was released from cavity biodegradable, submicron pentosan flask‐like nanobots, aggregates dynamic rotating fluid under field. nanobot swarm...
During chemotaxis and phototaxis, sperm, algae, marine zooplankton, other microswimmers move on helical paths or drifting circles by rhythmically bending cell protrusions called motile cilia flagella. Sperm of invertebrates navigate in a chemoattractant gradient adjusting the flagellar waveform and, thereby, swimming path. The is periodically modulated Ca2+ oscillations. How signals elicit steering responses shape path unknown. We unveil signal transfer between changes intracellular...
Abstract The generation of a sub-diffraction longitudinally polarized spot is great interest in various applications, such as optical tweezers, super-resolution microscopy, high-resolution Raman spectroscopy, and high-density data storage. Many theoretical investigations have been conducted into the tight focusing with high-numerical-aperture aplanatic lenses combination filters. Optical super-oscillation provides new approach to light beyond diffraction limit. Here, we propose planar binary...
Optical super-resolution diffractive metalenses have been promising candidates for realizing optical imaging and a microscope beyond the Abbe diffraction limit. An achromatic metalens is particularly important practical applications; however, it remains challenging to achieve high-numerical-aperture subwavelength focusing. Herein, holographic approach of multiwavelength focusing proposed. Through wavefront engineering synthesis, demonstrated at five different wavelengths 520, 555, 632.8,...
Abstract Recently, developments in superoscillatory optical devices have allowed for label‐free far‐field super‐resolution technology by allowing engineering of point‐spread functions beyond the traditional Abbe diffraction limit. However, such are optimized normal‐incident operation, which inevitably leads to a comparatively slow imaging acquisition rate application microscopy. Here, metalens is demonstrated with high numerical aperture that can focus oblique incident light into hot spot...
Inspired by the self-assembly phenomena in nature, instructed of exogenous small molecules a biological environment has become prevalent process to control cell fate. Despite mounting examples versatile bioactivities, underlying mechanism remains less understood, which is large hindered difficulties identification those dynamic assemblies situ. Here, with direct stochastic optical reconstruction microscopy, we are able elucidate morphology transformation enzyme-instructed supramolecular situ...
Laminar blood flow represents the normal physiological state of circulation, but it also acts as a natural barrier for effective diffusion drugs to lesion site. Here, we report bioinspired strategy in which reconfigurable vortexlike swarms magnetic swimming nanobots actively disrupt laminar deliver manner similar how bacteria seek food. The drug was released from cavity biodegradable, submicron pentosan flask-like nanobots, aggregates dynamic rotating fluid under field. nanobot swarm...
Quasi-non-diffracting beams are attractive for various applications, including optical manipulation, super-resolution microscopes, and materials processing. However, it is a great challenge to design generate super-long quasi-non-diffracting with sub-diffraction sub-wavelength size. In this paper, method based on the idea of compressing normalized angular spectrum developed, which makes possible provides practical tool beam super-oscillatory transverse It also presents clear physical picture...
A three-dimensional (3D) hollow spot is of great interest for a wide variety applications such as microscopy, lithography, data storage, optical manipulation, and manufacturing. Based on conventional high-numerical-aperture objective lenses, various methods have been proposed the generation 3D spots different polarizations. However, optics are bulky, costly, difficult to integrate. More importantly, they diffraction-limited in nature. Owing their unique properties small size, light weight,...
Sub-diffraction quasi-non-diffracting beams with sub-wavelength transverse size are attractive for applications such as optical nano-manipulation, nano-fabrication, high-density storage, and super-resolution microscopy. In this paper, we proposed an optimization-free design approach demonstrated the possibility of generating sub-diffraction different polarizations by a binary-phase Fresnel planar lens. More importantly, method significantly simplifies procedure generation sub-diffracting...
Superoscillatory optical devices have been widely investigated in the past several years. Due to their unique focusing properties, ones that focus cylindrically polarized waves are attractive for such applications as super-resolution imaging and particle manipulation. However, superoscillatory lenses reported of light suffer from difficulties related precise coaxial alignment, which might lead substantial distortions features. Moreover, conventional polarization converters only a narrow...
Abstract Optical hollow beams are suitable for materials processing, optical micromanipulation, microscopy, and lithography. However, conventional diffraction-limited. The generation of sub-wavelength using a high numerical aperture objective lens pupil filters has been theoretically proposed. Although sub-diffraction spot reported, nondiffracting transverse dimensions have not yet experimentally demonstrated. Here, planar based on binary-phase modulation is proposed to overcome these...
Oriented arrangement of single crystals plays a key role in improving the performance their functional devices. Herein we describe method for exceptionally fast fabrication (mm/min) ultralong aligned dipeptide (several centimeters). It combines an induced nucleation step with continuous withdrawal substrate, leading to specific evaporation/composition conditions at three-phase contact line, which makes growth process controllable. These fibers possess uniform cross section active optical...
Diabetes is associated with vascular remodeling and increased thrombin generation. Thrombin promotes smooth muscle cell (SMC) mitogenesis migration via protease-activated receptors (PAR)-1, PAR-3, PAR-4. We investigated the effect of high glucose on expression function receptors.In human SMCs, (25 versus 5.5 mmol/L) induced a rapid sustained increase in PAR-4 mRNA, protein, surface expression. PAR-1 PAR-3 were not changed. High pretreatment (48 hours) enhanced or PAR-4-activating peptide but...
Abstract Objective Interstitial fluid in extracellular matrices may not be totally fixed but partially flow through long‐distance oriented fibrous connective tissues via physical mechanisms. We hypothesized there is a interstitial transport network beyond vascular circulations. Materials and methods first used 20 volunteers to determine hypodermic entrant points visualize extravascular pathway by MRI. then investigated the pathways initiating from point of thumb cadavers chest compressor....
Exact knowledge of the numerical aperture is crucial in many applications using high-aperture objectives such as confocal microscopy, optical trapping, or advanced sub-wavelength imaging methods. We propose and apply a precise straightforward method for measuring this fundamental parameter microscope with apertures above unity. Our exploits peculiarities fluorescence emission molecules at glass/air interface.
Breaking the traditional Abbe diffraction limit to realize super-resolution is attractive for many applications. In past decades, based on concept of optical superoscillation, different types superoscillation lenses have been demonstrated with focal spot size smaller than limit, showing promising potentials realizing imaging and microscopy. Although inverse design methods without optimization procedure proposed, resulting transmission functions usually consist both amplitude phase, making it...
OBJECTIVES: Although the microcirculatory dysfunctions of edema formation are well documented, draining pattern dermal lacks information. This study was to assess potential drainage pathways interstitial fluid in patients with ankle using anatomical and histologica l methods. METHODS AND RESULTS: Four amputees lower leg participated this study. Fluorescent imaging agent injected into lateral dermis one volunteered patient before amputation three legs after amputation. Physiologically...
Nondiffracting light beams receive substantial attention in various areas due to their properties of diffractionless propagation and achievable subwavelength beam size. Extending the distance compressing size nondiffracting are crucial practical applications. However, it remains challenging achieve with a subdiffracting transverse long controllable intensity profiles both longitudinal directions. Here, we propose an optimization method generate ultralong-superoscillation full control...
Superoscillation metalenses have demonstrated promising prospects in breaking the theoretical diffraction limitations on resolution of optical devices and systems. However, most reported superoscillation a very small field view several tenths degree, which greatly limits their applications imaging microscopy. Therefore, it is critical importance to achieve absolute high by increasing numerical apertures (NAs) Unfortunately, similar case traditional optics, challenging realize large at NA,...
Tissue channels as a part of microcirculation system have been proposed over three decades, playing an important role in fluid transportation reported. Adventitia inferior vena cava (IVC) is typical hierarchical porous media with abundant tissue channels. Its behaviors attract massive research interest. However, the mechanism driving force and microstructure was lack deep research.This study to investigate microstructural basis within (IVC).Rat IVC samples were extracted fixed on gelatin...
Far-field super-resolution lenses are attractive due to their great potential in the application of label-free far-field optical super-resolution. In past decades, there has been a fast development superoscillatory lenses, which allows engineering point-spread functions beyond traditional Abbe diffraction limit. With decrease focal spot size, sidebands will inevitably increase, especially when size is close 0.358λ/NA, where NA numerical aperture. However, it critical importance reduce while...
A wide variety of practical applications utilize three-dimensional (3D) hollow spots. To improve their performance, it is critical to independently control the transverse and longitudinal size a 3D spot. Here, we propose method creating superoscillation spot by properly engineering spatial polarization distribution. cylindrical vector wave can be generated sizes controlled individually optimizing fronts radial azimuthal components in wave. metalens integrated with functions conversion...
Using the maximum-entropy method, we calculate end-to-end distance distribution of force stretched chain from moments distribution, which can be obtained extension-force curves recorded in single-molecule experiments. If one knows expansion extension through $(n-1)$th power force, it is enough information to $n$ distribution. We examine method with three stretching models, Gaussian chain, free-joined and excluded-volume on two-dimension lattice. The reconstructs all distributions precisely....