A5080821032- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Psychedelics and Drug Studies
- Biochemical Analysis and Sensing Techniques
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Human auditory perception and evaluation
- Circadian rhythm and melatonin
- Neurotransmitter Receptor Influence on Behavior
- Cardiovascular Syncope and Autonomic Disorders
- Cannabis and Cannabinoid Research
- Diet and metabolism studies
- Nicotinic Acetylcholine Receptors Study
- Advanced Chemical Sensor Technologies
- Regulation of Appetite and Obesity
Universidad de la República de Uruguay
2015-2024
Universidad de Montevideo
2019
Abstract In most mammals, the sleep-wake cycle is constituted by three behavioral states: wakefulness (W), non-REM (NREM) sleep, and REM sleep. These states are associated with drastic changes in cognitive capacities, mostly determined function of thalamo-cortical system. The intra-cranial electroencephalogram or electocorticogram (ECoG), an important tool for measuring activity during W present study we analyzed broad-band ECoG recordings rat means a time-series complexity measure that easy...
Abstract Recent studies have shown that slow cortical potentials in archi‐, paleo‐ and neocortex can phase‐lock with nasal respiration. In some of these areas, gamma activity (γ: 30–100 Hz) is also coupled to the animal's It has been hypothesized functional relationships play a role coordinating distributed neural activity. similar way, inter‐cortical interactions at γ frequency associated as binding mechanism by which brain generates temporary opportunities necessary for implementing...
Abstract Recently, a novel type of fast cortical oscillatory activity that occurs between 110 and 160 Hz (high‐frequency oscillations ( HFO )) was described. are modulated by the theta rhythm in hippocampus neocortex during active wakefulness REM sleep. As theta‐ coupling increases , role for memory consolidation has been proposed. However, global properties such as cortex‐wide topographic distribution cortico‐cortical coherence remain unknown. In this study, we recorded electroencephalogram...
During cognitive processes, there are extensive interactions between various regions of the cerebral cortex.Oscillations in gamma frequency band (30-100 Hz) electroencephalogram involved binding spatially separated but temporally correlated neural events, which results a unified perceptual experience.Like wakefulness, REM sleep is characterized by oscillations EEG.Dreams, that considered special type activity or protoconsciousness, mostly occur during this state.The power band, assessed fast...
Abstract Higher cognitive functions require the integration and coordination of large populations neurons in cortical subcortical regions. Oscillations gamma band (30–45 Hz) electroencephalogram ( EEG ) have been involved these functions. In previous studies, we analysed extent functional connectivity between areas employing ‘mean squared coherence' analysis band. We demonstrated that coherence is maximal during alert wakefulness almost absent rapid eye movement REM sleep. The nucleus pontis...
Cognitive processes are carried out during wakefulness by means of extensive interactions between cortical and subcortical areas. In psychiatric conditions, such as psychosis, these altered. Interestingly, REM sleep where most dreams occurs, shares electrophysiological, pharmacological, neurochemical features with psychosis. Because this fact, is considered a natural model Ketamine non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist that at sub-anesthetic dose induces...
The sleep-wake cycle is constituted by three behavioral states: wakefulness (W), non-REM (NREM) and REM sleep. These states are associated with drastic changes in cognitive capacities, mostly determined the function of thalamo-cortical system, whose activity can be examined means intra-cranial electroencephalogram (iEEG). With purpose to study depth basal iEEG adult rats, we analyzed spectral power coherence during W sleep paleocortex (olfactory bulb), neocortical areas. We also laterality...
Ibogaine is a psychedelic alkaloid that has attracted large scientific interest because of its antiaddictive properties in observational studies humans as well animal models. Its subjective effect been described intense, vivid dream-like experiences occurring while awake; hence, ibogaine often referred to an oneirogenic psychedelic. While this unique profile hypothesized aid the effects, electrophysiological signatures state remain unknown. We previously showed rats promotes waking with...
There is increasing evidence that the level of consciousness can be captured by neural informational complexity: for instance, complexity, as measured Lempel Ziv (LZ) compression algorithm, decreases during anaesthesia and non-rapid eye movement (NREM) sleep in humans rats, when compared with LZ awake REM sleep. In contrast, higher under effect psychedelics, including subanaesthetic doses ketamine. However, it both unclear how this result would modulated varying ketamine doses, whether...
Abstract Recent studies have shown that slow cortical potentials in archi-, paleo- and neocortex, can phase-lock with nasal respiration. In some of these areas, gamma activity (γ: 30-100 Hz) is also coupled to the animal’s It has been hypothesized this interaction plays a role coordinating distributed neural activity. similar way, inter-cortical interactions at γ frequency associated as binding mechanism by which brain generates temporary opportunities necessary for implementing cognitive...
Abstract There is increasing evidence that level of consciousness can be captured by neural informational complexity: for instance, complexity, as measured the Lempel Ziv (LZ) compression algorithm, decreases during anesthesia and non-rapid eye movement (NREM) sleep in humans rats, when compared to LZ awake REM sleep. In contrast, higher under effect psychedelics, including subanesthetic doses ketamine. However, it both unclear how this result would modulated varying ketamine doses, whether...
Abstract The states of sleep and wakefulness are critical physiological processes associated with different brain patterns activity. intracranial electroencephalogram allows us to measure these changes, thus, it is a tool for its study. Recently, we showed that the electrocortical temporal complexity decreased from sleep. Nevertheless, origin this complex activity remains controversial topic due existence possible artifacts contaminating signals. In work, decreases during sleep,...
Abstract Ibogaine is a psychedelic alkaloid that has attracted scientific interest because of its important antiaddictive properties evidenced in observational studies humans, and models for substance-use-disorders rodents. Its subjective effect been described as intense vivid dream-like experiences occurring while awake; hence, ibogaine often referred to an oneirogenic psychedelic. While this unique profile hypothesized aid the effects past, electrophysiological signatures state remain...
Abstract The electrical activity of the brain, characterized by its frequency components, reflects a complex interplay between periodic (oscillatory) and aperiodic components. These components are associated with various neurophysiological processes, such as excitation-inhibition balance (aperiodic activity) or interregional communication (oscillatory activity). However, we do not fully understand whether these truly independent if different neuromodulators modulate them in ways....