A5015833740- Parasitic Infections and Diagnostics
- Coccidia and coccidiosis research
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Child Nutrition and Water Access
University of Vermont
2018-2024
Cryptosporidiosis is a leading cause of life-threatening diarrhea in children, and the only currently approved drug ineffective malnourished children immunocompromised people. Large-scale phenotypic screens are ongoing to identify anticryptosporidial compounds, but optimal approaches prioritize inhibitors establish mechanistically diverse development pipeline unknown. Here, we present panel medium-throughput mode action assays that enable testing compounds several stages Cryptosporidium life...
Cryptosporidiosis causes life-threatening diarrhea in infants, but the best available treatment is only modestly efficacious. Rodents infected with relevant Cryptosporidium species do not develop diarrhea, which complicates drug development. parvum infection of dairy calves, however, an illness like that seen infants. Here, clinical and microbiologic anti-Cryptosporidium efficacy piperazine-based compound MMV665917 was demonstrated neonatal calves. Oral administration (22 mg/kg once daily)...
The apicomplexan parasite Cryptosporidium is a leading cause of childhood diarrhea in developing countries. Current treatment options are inadequate and multiple preclinical compounds being actively pursued as potential drugs for cryptosporidiosis. Unlike most apicomplexans, spp. sequentially replicate asexually then sexually within single host to complete their lifecycles. Anti-cryptosporidial generally identified or tested through vitro phenotypic assays that only assess the asexual...
Despite significant progress in recent decades toward ameliorating the excess burden of diarrheal disease globally, childhood diarrhea remains a leading cause morbidity and mortality low-and-middle-income countries (LMICs). Recent large-scale studies etiology these populations have revealed widespread co-infection with multiple enteric pathogens, both acute asymptomatic stool specimens. We applied methods from network science ecology to better understand underlying structure among infants...
Abstract The apicomplexan parasite Cryptosporidium is a leading cause of childhood diarrhea in developing countries. Current treatment options are inadequate and multiple preclinical compounds being actively pursued as potential drugs for cryptosporidiosis. Unlike most apicomplexans, spp. sequentially replicate asexually then sexually within single host to complete their lifecycles. Anti-cryptosporidial generally identified or tested through vitro phenotypic assays that only assess the...