P. K. M. Koya

ORCID: 0000-0002-8596-1235
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Research Areas
  • Radiation Therapy and Dosimetry
  • Carcinogens and Genotoxicity Assessment
  • Effects of Radiation Exposure
  • Congenital Anomalies and Fetal Surgery
  • Birth, Development, and Health
  • Radioactivity and Radon Measurements
  • Prenatal Screening and Diagnostics
  • Radiation Dose and Imaging
  • DNA Repair Mechanisms
  • Global Maternal and Child Health
  • Demographic Trends and Gender Preferences
  • Obesity, Physical Activity, Diet
  • Nuclear Issues and Defense
  • Radioactive contamination and transfer
  • Effects and risks of endocrine disrupting chemicals
  • Congenital Heart Disease Studies
  • Migration and Labor Dynamics
  • Child Nutrition and Water Access
  • Nuclear and radioactivity studies
  • Electromagnetic Fields and Biological Effects
  • Genomic variations and chromosomal abnormalities
  • Autopsy Techniques and Outcomes

Bhabha Atomic Research Centre
2002-2023

Bhabha Atomic Research Center Hospital
2012

Cytogenetic studies using cord blood samples from newborns high-level natural radiation areas of the Kerala coast in Southwest India have been progress since 1986. A total 963,940 metaphases 10,230 screened for various types chromosomal aberrations. Comparison 8,493 (804,212 cells) (dose rate >1.5 mGy/year) and 1,737 (159,728 normal-level (</=1.5 did not show any significant difference frequency dicentrics, translocations, inversions or other aberrations known to be associated with exposure....

10.2307/3580136 article EN Radiation Research 1999-12-01

In the densely populated monazite-bearing sands of Kerala, on southwest coast India, natural radiation dose rates range from 1. 0 to over 35.0 mGy per year in certain well-defined high-level areas. As a part program assess health effects this naturally occurring human populations, monitoring newborns is being undertaken determine incidence congenital malformations. From August 1995 December 1998, total 36,805 were screened, including 212 (0.58%) stillbirths. There 36,263 singletons, 536...

10.2307/3580135 article EN Radiation Research 1999-12-01

Journal Article Deposition-based passive monitors for assigning radon, thoron inhalation doses epidemiological studies Get access Y. S. Mayya, Mayya * 1Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai, India *Corresponding author: mayyays@barc.gov.in Search other works by this author on: Oxford Academic PubMed Google Scholar R. Mishra, Mishra Prajith, Prajith A. C. Gole, Gole B. K. Sapra, Sapra M. P. Chougaonkar, Chougaonkar Nair, Nair 2Regional Cancer...

10.1093/rpd/ncs196 article EN Radiation Protection Dosimetry 2012-08-28

A population-based 1:3 age-matched case-control study was conducted during 2006–2009 to assess the role of high-level natural radiation (>1 mSv/year) on congenital mental retardation and cleft lip/palate in southwest coastal area Kerala. Dosimetry carried out house where parents resided conception subsequent two trimesters pregnancy subject. Conditional logistic regression did not suggest any statistically significant association either (n = 445) or 116) with radiation. The odds among those...

10.1667/rr2699.1 article EN Radiation Research 2011-12-21

The present study investigates whether the chronic low-dose radiation exposure induces an in vivo radio-adaptive response individuals from high-level natural areas (HLNRA) of Kerala coast. Peripheral blood samples 54 adult male aged between 26 and 65 years were collected for with written informed consent. Each whole sample was divided into three, one sham irradiated, second third exposed to challenging doses 1.0 2.0 Gy gamma radiation, respectively. Cytokinesis-block micronucleus (CBMN)...

10.1093/mutage/gew057 article EN Mutagenesis 2016-10-24

To study, characterize and compare chromosome aberrations karyotype anomalies among newborns from high (> 1.5 mGy/y) normal (≤ level natural radiation areas of monazite-sand bearing southwest coast Kerala in India.Cord blood samples were collected selected Government hospitals heparinized vials cultures set up employing standard microculture techniques, slides prepared, coded stained with giemsa. Well spread metaphases analyzed for anomalies.A total 1,267,788 27,295 mothers aged 17-45 years...

10.3109/09553002.2013.747014 article EN International Journal of Radiation Biology 2012-11-07

Background: Single Nucleotide Polymorphisms (SNPs) at DNA repair genes are considered as potential biomarkers of radio-sensitivity. The coastal belt Kerala in south west India has a patchy distribution monazite its beach sand that contains Th-232 and decay products. Thus, radiation levels this area vary from <1.0mGy to 45.0mGy/year. areas with external gamma dose >1.5mGy/year High-Level Natural Radiation Areas (HLNRA) ≤ 1.5mGy/year Normal Level Area (NLNRA).Objective: In the present study,...

10.1080/09553002.2020.1739771 article EN International Journal of Radiation Biology 2020-03-09

Abstract Background The human population residing in monazite bearing Kerala coast are exposed to chronic low dose and rate external gamma radiation due Th232 deposits its beach sand. level this area varies from &lt; 1.0 45.0 mGy/year. This serves as an ideal source for conducting large-scale epidemiological studies assessing risk of exposure on population. areas with a ≤1.50 mGy/year considered normal natural (NLNRAs) &gt; 1.50 mGy/year, high (HLNRAs). HLNRAs were further stratified into...

10.1186/s41021-021-00231-0 article EN cc-by Genes and Environment 2022-01-04

Journal Article Inhalation and external doses in coastal villages of high background radiation area Kollam, India Get access S. Ben Byju, Byju 1Department Physics, Fatima Mata National College, Kerala 691001, Search for other works by this author on: Oxford Academic PubMed Google Scholar P. K. M. Koya, Koya 2Low Level Radiation Research Laboratory, Bhabha Atomic Centre, B. Sahoo, Sahoo 3Radiological Physics Advisory Division, Mumbai 400085, J. Jojo, Jojo * *Corresponding author:...

10.1093/rpd/ncs213 article EN Radiation Protection Dosimetry 2012-09-07

Abstract Background The human population living in high level natural radiation areas (HLNRAs) of Kerala coast provide unique opportunities to study the biological effects low dose and rate ionizing below 100 mGy. this area varies from &lt; 1.0 45 mGy/year. with ≤ 1.50 mGy/year are considered as normal (NLNRA) &gt; mGy/year, (HLNRA). present evaluated response relationship between DNA double strand breaks (DSBs) background individuals residing coast. Venous blood samples were collected 200...

10.1186/s41021-023-00273-6 article EN cc-by Genes and Environment 2023-05-01
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