m6A modification is the most prevalent RNA in eukaryotes. As critical N6-methyladenosine (m6A) methyltransferase, roles of methyltransferase like 3 (METTL3) colorectal cancer (CRC) are controversial. Here, we confirmed that METTL3, a could facilitate CRC progression vitro and vivo. Further, found METTL3 promoted cell proliferation by methylating site 3'-untranslated region (UTR) CCNE1 mRNA to stabilize it. Moreover, butyrate, classical intestinal microbial metabolite, down-regulate...

Abstract Increasing evidence has indicated a close association between immune infiltration in cancer and clinical outcomes. However, related research thyroid is still deficient. Our comprehensively investigated the of cancer. Data derived from TCGA GEO databases were analyzed by CIBERSORT, ESTIMATE, EPIC algorithms. The CIBERSORT algorithm calculates proportions 22 types cells. ESTIMATE stromal score to represent all cells cancer-associated fibroblasts (CAFs) endothelial (ECs), which are...

Abstract With the increasing incidence of papillary thyroid cancer (PTC), more attention has been paid to exploring mechanism PTC initiation and progression. In addition, ectopic expression long noncoding RNAs (lncRNAs) is reported play a pivotal role in multiple human cancers. Based on these findings, we examined lncRNA ABHD11 antisense RNA 1 (ABHD11-AS1) its clinical significance, biological function PTC. First, analyzed ABHD11-AS1 The Cancer Genome Atlas (TCGA) Gene Expression Omnibus...

Thyroid cancer is the most common endocrine malignancy, papillary thyroid carcinoma (PTC) main form of cancer. The long non-coding RNA (lncRNA) zinc finger antisense 1 (ZFAS1) highly expressed in various tissues and it has been shown to function as a tumor promoter cellular processes. However, role ZFAS1 PTC not well understood currently. Thus, this study aimed explore potential roles development progression PTC.PTC (n=80) noncancerous were collected. Gain- loss-of-function assays performed...

Accurate prediction of extrathyroidal extension and subsequent recurrence is crucial in papillary thyroid cancer clinical management. Our aim was to conduct iodine map-based radiomics predict explore its prognostic value for recurrence-free survival cancer. A total 452 patients with were retrospectively recruited between June 2017 2020. Radiomics features extracted from noncontrast images, dual-phase mixed maps, respectively. Random forest least absolute shrinkage selection operator (LASSO)...

Abstract Purpose To study the influence of sex, age and thyroid function indices on dual-energy computed tomography (DECT)-derived quantitative parameters in patients with or without Hashimoto’s thyroiditis (HT). Material methods A total 198 consecutive who underwent DECT scan neck due to unilateral lesions were retrospectively enrolled. Iodine concentration (IC), iodine content (TIC) volume normal lobe calculated. Influences DECT-derived overall population, subgroup with, those HT assessed...

High level of serum tumor abnormal protein (TAP) may be useful in early diagnosis cancers. This study aims to investigate the diagnostic value TAP patients with papillary thyroid carcinoma (PTC).Abnormal sugar chain glycoproteins from peripheral blood 139 PTC, 39 benign nodular and 35 healthy individuals were used. Receiver operating characteristic (ROC) curve was performed evaluate (TAP). Moreover, relationship between its clinical characteristics further analyzed.TAP significantly higher...

Objectives The current study evaluates the performance of dual-energy computed tomography (DECT) derived extracellular volume (ECV) fraction based on dual-layer spectral detector CT for diagnosing cervical lymph nodes (LNs) metastasis from papillary thyroid cancer (PTC) and compares it with value ECV conventional single-energy (SECT). Methods One hundred fifty-seven LNs (81 non-metastatic 76 metastatic) were recruited. Among them, 59 (27 32 affected by root artifact contrast-enhanced images...

Background Computed tomography texture analysis (CTTA) provides objective and quantitative information regarding tumor heterogeneity beyond visual inspection. However, no study has yet used CTTA to differentiate metastatic from non-metastatic cervical lymph node in patients with papillary thyroid cancer (PTC). Purpose To evaluate the value of dual-phase contrast-enhanced CT images diagnosing metastasis PTC. Material Methods Metastatic (n = 27) 32) nodes were analyzed retrospectively. Texture...

With the improvement in diagnostic technology, incidence of thyroid cancer (TC) is on rise. Papillary carcinoma (PTC) most common pathological type cancer; therefore, it important to explore some valuable molecular targets improve treatment and prognosis PTC. Studies have shown that family with sequence similarity 84, member A (FAM84A) involved development various tumors. However, role FAM84A PTC remains unknown. Herein, we explored biological function specific mechanism Results indicated...

To evaluate the effect of Hashimoto's thyroiditis (HT) on dual-energy computed tomography (DECT) quantitative parameters cervical lymph nodes (LNs) in patients with papillary thyroid cancer (PTC), and its diagnostic performance threshold DECT preoperatively identifying metastatic LNs. A total 479 LNs from 233 PTC were classified into four groups: HT+/LN+, HT+/LN-, HT-/LN + - group. including iodine concentration (IC), normalized IC (NIC), effective atomic number (Zeff), slope spectral...

<title>Abstract</title> <bold>Objective: </bold>To explore a better tracing of central lymph nodes in papillary thyroid carcinoma patients by comparing the differences number and staining nano-carbon extravasation between preoperative ultrasound- guided injection intraoperative nano-carbon. <bold>Methods: </bold>Totally 302 were randomly divided into group an group. The each sub-area region recorded analyzed, including linea alba cervical nodes, Delphian pretracheal paratracheal nodes....

Abstract Background Long noncoding RNAs (lncRNAs) have emerged as crucial regulators in various cancers. However, the functional roles of most lncRNA papillary thyroid cancer (PTC) are not detailly understood. This study aims to investigate biological function and molecular mechanism Fer-1 like family member 4 (FER1L4) PTC. Methods The expression FER1L4 PTC was determined via operating quantitative real-time PCR assays. Meanwhile, clinical significance patients with described. functions on...

Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) is a recurrent phenomenon during clinical therapy of non-small-cell lung cancer (NSCLC). Studies have shown that HER2 key contributing drug in variety cancers. Furthermore, we observed overexpressed PC-9 NSCLC cells with acquired gefitinib-resistance (PC-9/GR) as compared cells.We hypothesized blocking both EGFR and may serve potential strategy for the treatment gefitinib-resistance.To target...

<title>Abstract</title> Background Thyroid cancer, particularly papillary thyroid carcinoma (PTC), is one of the most common malignant tumors endocrine system. Malignant biological behaviors such as tumor invasion and cervical lymph node metastasis are closely associated with prognosis PTC. To date, no effective method has been identified to accurately predict invasive behavior Objective This study aims investigate potential molecular mechanisms underlying high invasiveness PTC mediated by...

Multifocal Papillary thyroid carcinoma (PTC) is a very common condition. In certain cases, it possible to find tens hundreds of foci with diffuse intrathyroidal spread in the whole no stromal fibrosis. Herein, PTC such features was nominated as disseminate variant (DDV) PTC. The aim present study investigate histopathological characteristics, molecular features, and biological behavior DDV compare characteristics sclerosing (DSV) PTC.Thirty-four 23 DSV cases were identified from consecutive...

To explore better methods for tracing central lymph nodes in patients with papillary thyroid carcinoma by comparing the differences numbers and staining rates of as well degree nanocarbon extravasation between preoperative ultrasound-guided injection particles intraoperative particles. A total 302 were randomly divided into a group an group. The number each subgroup nodes, including linea alba cervical Delphian pretracheal paratracheal recorded analyzed. extent dye was reduced when injected...