A5039277834- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Head and Neck Surgical Oncology
- Spinal Fractures and Fixation Techniques
- Cerebral Palsy and Movement Disorders
- Antifungal resistance and susceptibility
- Surgical Simulation and Training
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Cancer-related cognitive impairment studies
- Neurological disorders and treatments
- Meningioma and schwannoma management
- Traumatic Brain Injury Research
- Diversity and Career in Medicine
- Pneumocystis jirovecii pneumonia detection and treatment
- Dental Implant Techniques and Outcomes
- Ubiquitin and proteasome pathways
- Ocular Oncology and Treatments
- Trigeminal Neuralgia and Treatments
- Fungal Infections and Studies
- Esophageal and GI Pathology
- Scoliosis diagnosis and treatment
University of Oklahoma Health Sciences Center
2024-2025
University of Oklahoma
2022-2025
Oklahoma City University
2025
Indiana University School of Medicine
2018-2024
Indiana University – Purdue University Indianapolis
2018-2024
Children's Hospital of Oklahoma
2023-2024
Neurological Surgery
2004-2023
Indiana University
2022
Riley Hospital for Children
2018-2022
George Mason University
2022
Abstract The increasing number of cancer survivors has brought heightened attention to the side effects therapies, including chemotherapy-related cognitive impairment (CRCI, commonly referred as “chemobrain”). Cisplatin and methotrexate, used first-line chemotherapeutics in gynecologic oncology for cancers such breast, ovarian, bladder cancer, are clinically associated with long-term deficits. Building on our previous preclinical studies demonstrating that paclitaxel chemotherapy induces...
In this paper, we studied factors related to long-term survival after gamma knife radiosurgery (GKS) for primary and metastatic brain tumors. We examined all cases of metastases malignant glioma treated with GKS between September 1994 December 1998. All patients exceeding 2 years were retrospectively using prospectively acquired data. A total 22 patients, an average age 56, identified, which accounts 11% the during time interval. Seventeen are still alive a mean follow-up 48 months. Sixteen...
OBJECTIVE The revelation of normative radiographic measurements for the developing pediatric spine is incomplete. purpose this analysis was to determine normal range asymmetry lateral atlantodental interval (LADI) and define age- sex-related differences. METHODS A total 3072 children aged 0-18 years who underwent CT scanning cervical were identified at Riley Hospital Children between 2005 2017. Patients stratified by sex age (in years) into 36 cohorts. Following stratification, patients...
OBJECTIVE Quality improvement (QI) tools are increasingly being used to calibrate healthcare quality. Achieving quality is essential, as there a movement toward value-based delivery. Visual management, such living Pareto chart, strategy for within the QI framework. The authors herein hypothesized that transparency of data through chart powerful way improve patient outcomes and gain clinical efficiency. METHODS retrospectively reviewed complications; cerebrospinal fluid (CSF) leaks; shunt,...
Introduction: The endoscopic endonasal approach (EEA) is the preferred option for many skull base pathologies because it minimally invasive, but can be challenging in pediatric population. Here, we aim to review our experience of approaches, including clinical presentation, surgical pathology, anatomical considerations, and complications over a 14-year period.
OBJECTIVE The goal of this study was to evaluate the impact endoscopic third ventriculostomy (ETV) failure on subsequent risk ventriculoperitoneal shunt (VPS) placement. METHODS A retrospective chart review performed identify pediatric patients receiving ETV followed by a VPS at Oklahoma Children’s Hospital between January 1, 2016, and December 31, 2021. control group alone also gathered. Complication rates were compared 2 groups 12 months postoperatively. RESULTS total 222 included in...
BACKGROUND As part of the laterotrigeminal venous system (LTVS), emissary vein foramen ovale (EVFO) is an underrecognized structure communicating between cavernous sinus and pterygoid plexus. The sphenobasal anatomical variation sphenoparietal that drains directly into EVFO. authors present case a ruptured arteriovenous malformation (AVM) with unique drainage pattern through OBSERVATIONS A 9-year-old female initially presented loss consciousness was subsequently found to have AVM in left...
Mucormycosis is an angioinvasive lethal fungal infection in pediatric cancer patients. We present 10-year-old female with relapsed B-cell acute lymphoblastic leukemia undergoing chemotherapy was diagnosed isolated cerebral mucormycosis (ICM). Despite surgical debridement and liposomal amphotericin B, repeat imaging showed concern for disease progression. Chemotherapy discontinued the patient discharged on salvage therapy oral isavuconazole (ISAV). Over two months later, unexpectedly...
OBJECTIVE Time-driven activity-based costing (TDABC) is a method used in cost accounting that has gained traction health economics to identify value optimization initiatives. It measures time, assigns time increments spent on patient, and integrates the of material human resources utilized each episode care. In this study, authors report first use TDABC evaluate costs pediatric neurosurgical practice. METHODS A clinical pathway was developed with multifunction team. survey among care team...
Abstract Pediatric gliomas are the most common type of pediatric brain tumors representing wide range molecularly and clinically heterogenous subtypes. The hyperactivity mitogen-activated protein kinases (MAPK) pathway has been identified in majority glioma suggesting its therapeutic potential. However, pharmacologic targeting single MAPK pathway’s component is limited due to development drug resistance differential response associated with tumor molecular landscape. Therefore, effective...
Abstract Pleomorphic xanthoastrocytoma (PXA) is a rare subset of primary pediatric glioma with 70% 5-year disease free survival. However, up to 20% cases present local recurrence and malignant transformation into more aggressive type anaplastic PXA (AXPA) or glioblastoma. The understanding etiology mechanisms driving APXA are limited, there no standard care. Therefore, development relevant preclinical models investigate molecular underpinnings guide novel therapeutic approaches interest....
Mendenhall, Stephen K MD, BS; Huh, Andrew; Alentado, Vincent J MD; Balsara, Karl E Andrew H. Jea MHA Author Information
Department of Neurological Surgery Indiana University School Medicine Goodman Campbell Brain and Spine Indianapolis,
Abstract Social determinants of health (SDOH) have a significant impact on health, well-being, and quality life (QOL). Validated tools to assess these disparities been developed but not utilized prospectively in children with central nervous system tumors (CNS). OBJECTIVE: To establish baseline assessment health-related associated social CNS Indiana. METHOD: We implemented the Pediatric Quality Life Inventory™ (PedsQL™) for patients (ages 0-21 years) diagnosed tumor evaluated neuro-oncology...