Yakup Şirin

ORCID: 0000-0002-8759-0132
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Research Areas
  • Synthesis and biological activity
  • Synthesis and Biological Evaluation
  • Insect and Pesticide Research
  • Essential Oils and Antimicrobial Activity
  • Synthesis and Characterization of Heterocyclic Compounds
  • Bee Products Chemical Analysis
  • Computational Drug Discovery Methods
  • Phytochemicals and Antioxidant Activities
  • Cholinesterase and Neurodegenerative Diseases
  • Metal complexes synthesis and properties
  • Maritime and Coastal Archaeology
  • Phytase and its Applications
  • Protein Hydrolysis and Bioactive Peptides
  • Synthesis of β-Lactam Compounds
  • Food Quality and Safety Studies
  • Marine Sponges and Natural Products
  • Natural product bioactivities and synthesis
  • Folate and B Vitamins Research
  • Free Radicals and Antioxidants
  • Morinda citrifolia extract uses
  • Hops Chemistry and Applications
  • Phytochemical Studies and Bioactivities
  • Piperaceae Chemical and Biological Studies
  • Chemical synthesis and pharmacological studies
  • Botanical Research and Applications

Karadeniz Technical University
2016-2024

Humulus lupulus L., known as hop, is used mostly in brewing industry. It that hops have some secondary metabolites having significant biological activities. As far we know this the first paper reporting urease, α-amylase and acetylcholinesterase inhibition activity of hop extracts. In study, phenolic composition, antioxidant capacities, clinically important enzyme properties methanol extracts were investigated. Total polyphenolic content (TPC), ferric reducing power (FRAP)...

10.1016/j.sajb.2018.04.017 article EN cc-by South African Journal of Botany 2018-05-16

The growing interest in essential oils clearly indicates the power of nature and aligns with our increasing need to find therapeutic solutions natural world. This study aimed investigate inhibitory effects Mentha × piperita Salvia rosmarinus, harvested from Laghouat region Algeria, against Candida rugosa lipase (CRL) pancreatic through both vitro silico studies. Essential were extracted via hydrodistillation analyzed using gas chromatography-mass spectrometry spectrophotometry. Their...

10.55730/1300-0152.2725 article EN TURKISH JOURNAL OF BIOLOGY 2025-02-24

A novel phytase from thermophilic Geobacillus sp. TF16 was purified approximately 5-fold using ammonium sulfate precipitation and ion exchange chromatography, determined as a single band 106.04 kDa on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Optimum temperature optimum pH were found to be 85°C 4.0, respectively. The enzyme is highly thermostable Vmax Km values calculated 526.28 U/mg 1.31 mM, It also that the exhibited broad substrate selectivity resistance toward proteases...

10.1080/10942912.2016.1203930 article EN International Journal of Food Properties 2016-07-26

Abstract In this study, 1‐(4‐substitued benzyl)‐3,5‐diphenyl‐ 1H ‐1,2,4‐triazoles ( 2 a‐e ) and ethyl(3,5‐diphenyl‐ ‐1,2,4‐triazole‐1‐yl)acetate 3 were synthesized starting from 3,5‐diphenyl‐ ‐1,2,4‐triazole 1 ). The ethyl acetate derivative was converted to 2‐(3,5‐diphenyl‐ ‐1,2,4‐triazole‐1‐yl)acetohydrazide 4 in ethanolic medium with hydrazine hydrate. reaction of the acetohydrazide suitable isothiocyanates generate 2‐[(3, 5‐diphenyl‐...

10.1002/slct.201801578 article EN ChemistrySelect 2018-08-16

In this work, Geobacillus sp. TF16 phytase was separately immobilized in chitosan and Ca-alginate with the efficiency of 38% 42%, respectively. These enzymes exhibited broad substrate specificity. Maximal relative activity measured at pH 5.0 95°C 3.0 75°C for Ca-alginate, The were highly stable a wide temperature range. Values Km Vmax determined as 2.38 mM 3401.36 U/mg protein chitosan, 7.5 5011.12 Ca-alginate. showed higher resistance to proteolysis. After 4 h incubation, hydrolysis...

10.1080/10942912.2016.1261151 article EN International Journal of Food Properties 2016-11-24

In this study, twelve different mixtures were formed by ratios of honey (15%-78.5%) and propolis (1.5%-5%) to mulberry molasses increase its antioxidant, phenolic compound, mineral values, the physical chemical properties these pure products investigated.In analysis conducted in it was determined that among mixtures, highest antioxidant activity be sample A1, with a value 400.4 ± 1.0 mg/100 g FeSO4, whereas lowest found B4, 203.1 0.4 FeSO4. Regarding total content, identified 184.3 0.9 mg...

10.35206/jan.1451422 article EN Journal of Apitherapy and Nature 2024-06-30

Abstract Cholinesterase inhibitors are employed for treating different neuromuscular disorders that arise due to decreased levels of ACh in the cortical and hippocampal, such as Alzheimer’s disease. There is a need synthesize novel drug candidates improve therapeutic efficacy reduce side effects toxicity emerging resistance. Chitosan was grafted with quinolone derivatives using EDC NHS coupling agents. The newly synthesized quinolone-grafted chitosan were characterized by elemental analysis,...

10.1007/s00289-024-05371-1 article EN cc-by Polymer Bulletin 2024-06-25

The increasing demand for efficient juice extraction processes in response to rising global fruit product consumption underscores the importance of enzyme-mediated approaches, particularly utilizing pectinases, enhancing efficiency by breaking down plant cell wall components. This study focuses on investigating pectinase production from different Aspergillus spp. strains isolated natural resources Ankara, Turkey. By screening these strains, this research aims broaden spectrum working...

10.22541/au.172115198.88948966/v1 preprint EN Authorea (Authorea) 2024-07-16

Black mulberry is crucial for its high content of bioactive substances, such as phenolic compounds and vitamin C, well nutritional values, carbohydrates, fats, fibre minerals. This study aimed to determine the physical, biochemical properties 35 different brands black extracts sold in our country. Consequently studies, it was observed that some country had a very HMF value; most them contained no protein additional maltose derivatives. In addition, all these were low minerals sweeteners,...

10.15237/gida.gd24071 article EN GIDA / THE JOURNAL OF FOOD 2024-10-17

Wisteria is a plant species of the Fabaceae family with woody, flowering and climbing characteristics has about 10 subspecies. sinensis, abundant in Asian countries, highly attractive for honey bees due to its blue-violet, fragrant flowers. The flowers are mixed sugar flour make local meal (Teng Lo) East countries. Flowers can also be consumed as tea. sinensis have antioxidant antibacterial properties. It very rich terms polyphenols, saponins, flavones lectins. Because these properties, used...

10.7176/jstr/5-2-12 article EN International Journal of Scientific and Technological Research 2019-02-01

Spiraea nipponica is a plant belongs to the Rosaceae family. There are nearly one hundred species of spiraea plant. It can get longer as tall 1.5 3 m. The color flowers differ in white, red, pink and yellow. leaf fall winter season. which blossomed early spring without its branch seen if they were covered snow. That why named snow mound. In traditional medicine, root, fruit have been used diuretic, analgesic antitussive. Additionally, because essential oils has antimicrobial antifungal...

10.7176/jstr/5-2-10 article EN International Journal of Scientific and Technological Research 2019-02-01

Royal jelly (RJ) is an important functional food, used for many purposes. New methods are needed the practical characterization of royal jelly. In this preliminary study, SDS-PAGE electrophoretic profiles proteins were investigated. Raw samples analyzed by classical electrophoresis using 5% and 10% gels. The major protein spot obtained at collected same regions. Compared with known marker they between 50 80 kDa. Classical alone not sufficient to determine proteins, but can be basic Furthers...

10.35206/jan.638063 article EN Journal of Apitherapy and Nature 2019-11-09
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