A5100392111- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Ion Transport and Channel Regulation
- Neurogenesis and neuroplasticity mechanisms
- Molecular Sensors and Ion Detection
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Ion channel regulation and function
- Cellular transport and secretion
- Graph theory and applications
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Amino Acid Enzymes and Metabolism
- Drug Transport and Resistance Mechanisms
- Neurological Disorders and Treatments
- Receptor Mechanisms and Signaling
- Advanced biosensing and bioanalysis techniques
- Lipid Membrane Structure and Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- RNA regulation and disease
The Affiliated Yongchuan Hospital of Chongqing Medical University
2014-2020
Chongqing Medical University
2014-2020
Zhujiang Hospital
2019
Southern Medical University
2019
Xi'an Jiaotong University
2007
Abstract Major depressive disorder (MDD) is a severe mental associated with high rates of morbidity and mortality. Current first-line pharmacotherapies for MDD are based on enhancement monoaminergic neurotransmission, but these antidepressants still insufficient produce significant side-effects. Consequently, the development novel therapeutic targets desired. Dl-3-n-butylphthalide (NBP) compound proven efficacy in treating ischemic stroke, yet its effects mechanisms depression remain...
BackgroundNACHT and WD repeat domain-containing protein 1 (Nwd1) is a member of the innate immune subfamily. Nwd1 contributes to androgen receptor signaling pathway involved in axonal growth. However, mechanisms that underlie pathophysiological dysfunction seizures remain unclear.MethodsBiochemical methods were used assess expression localization mouse model kainic acid (KA)-induced acute temporal lobe epilepsy (TLE) patients. Electrophysiological recordings measure role regulating synaptic...
Abstract Tubulin β‐ III ( TUBB3 ) is the most dynamic β‐tubulin isoform expressed in neurons, and highly central nervous system. However, relationship between epileptic seizures has not been thoroughly investigated. The aims of this study were to investigate expression patients with temporal lobe epilepsy two different rat models chronic epilepsy, determine specific roles epilepsy. was upregulated human tissue. Moreover, associated inhibitory GABAergic neurons postsynaptic scaffold protein...
Abstract Epilepsy is one of the most prevalent and drug-refractory neurological disorders. Zinc finger DHHC-type containing 8 (ZDHHC8) a putative palmitoyltransferase that highly expressed in brain. However, impact ZDHHC8 on seizures remains unclear. We aimed to explore association with epilepsy investigate its epileptogenesis vivo vitro models through behavioral, electrophysiological, pathological studies. used kainic acid- pilocarpine-induced C57BL/6 mice magnesium-free-induced pyramidal...
Dysfunction of γ-aminobutyric acid A (GABAA) receptors (GABAARs) is a prominent factor affecting intractable epilepsy. Plic-1, an ubiquitin-like protein enriched in the inhibitory synapses connecting GABAARs and ubiquitin protease system (UPS), plays key role modification GABAAR functions. However, relationship between Plic-1 epileptogenesis not known. In present study, we aimed to investigate levels patients with temporal lobe epilepsy, as well regulating onset progression epilepsy animal...
Abstract The proprotein convertase Furin plays crucial roles in the pathology of many diseases. However, specific role furin epilepsy remains unclear. In our study, protein was increased temporal neocortex epileptic patients and hippocampus cortex mice. transgenic (TG) mice showed susceptibility to heightened activity compared with wild-type (WT) Conversely, lentivirus-mediated knockdown restrained activity. Using whole-cell patch clamp, overexpression influenced neuronal inhibitory by...
Objectives: Plenty of SH3 (POSH) was originally found to be a key regulator neuronal apoptosis, axon outgrowth, and migration. However, the role POSH in epilepsy has not been reported.Methods: We investigated expression patients with intractable temporal (TLE) kainic acid (KA)-induced mouse model, then we performed behavioral, electrophysiological biochemical analyses after lentivirus (LV)-mediated knockdown or overexpression KA-induced model.Results: shortened latency seizure onset,...
The imbalance between excitation and inhibition is a defining feature of epilepsy. GluA1 an AMPA receptor subunit that can strengthen excitatory synaptic transmission when upregulated in the postsynaptic membrane, which has been implicated pathogenesis cGKII, cGMP-dependent protein kinase, regulates levels at plasma membrane.To explore role cGKII epilepsy, we investigated expression patients with temporal lobe epilepsy (TLE) pilocarpine-induced rat model then performed behavioral,...