A5024099235- Lymphatic System and Diseases
- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Neonatal Respiratory Health Research
- Helicobacter pylori-related gastroenterology studies
- Circadian rhythm and melatonin
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Public Health Policies and Education
- Opioid Use Disorder Treatment
- Pharmaceutical Practices and Patient Outcomes
- Cancer, Lipids, and Metabolism
- Microscopic Colitis
- Syphilis Diagnosis and Treatment
- Hydrogen's biological and therapeutic effects
- Inflammatory Bowel Disease
- Congenital gastrointestinal and neural anomalies
- Pain Management and Opioid Use
- Global Health Workforce Issues
- Clostridium difficile and Clostridium perfringens research
- Adolescent Sexual and Reproductive Health
- Nosocomial Infections in ICU
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sleep and Wakefulness Research
- Music Therapy and Health
The University of Adelaide
2021-2025
Queen Elizabeth Hospital
2024-2025
Basil Hetzel Institute
2024
Flinders Medical Centre
2018-2023
Royal Adelaide Hospital
2021
University of Calgary
2012
University of California, Davis
2006
Rockefeller University Press
1977
Rockefeller University
1977
Mesenteric lymphatic vessels actively transport lymph, immune cells, fat, and other macromolecules from the intestine via a rhythmical contraction-relaxation process called pumping. We have previously demonstrated that mesenteric pumping was compromised in guinea pig model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced ileitis, corroborating clinical experimental observations dilated and/or obstructed phenotype these inflammatory bowel disease. Many mediators released during been shown...
Abstract Background Ozone (O 3 ), a common air pollutant, induces exacerbation of asthma and chronic obstructive pulmonary disease. Pulmonary surfactant protein (SP)-D modulates immune inflammatory responses in the lung. We have shown previously that SP-D plays protective role mouse model allergic airway inflammation. Here we studied regulation O -induced changes Methods To evaluate effects exposure strains with genetically different expression levels exposed Balb/c, C57BL/6 knockout mice to...
Fecal microbiota transplantation (FMT) sourced from a bank of prescreened anaerobically processed frozen donor stool has been available in South Australia since 2013. This study aimed to evaluate the real-world clinical and safety outcomes FMT for recurrent, refractory, and/or severe or fulminant Clostridioides difficile infection (CDI) facilitated via this centralized facility. Donor screening test data were prospectively collected on all donors who passed prescreening evaluations between...
Summary Background Constipation can be diagnosed clinically using the Rome criteria. Ultrasound (US), which lacks radiation exposure of conventional X‐ray, holds promise as a non‐invasive tool to evaluate colonic contents and constipation. Aim To examine role US in assessment Methods We performed systematic search Embase (OVID, 1984), Medline (Ovid, 1946), Cochrane Central, ClinicalTrials.gov Australia New Zealand Clinical Trials Registry from database inception 26 January 2024 according...
Lymphatic vessels serve as a route by which interstitial fluid, protein and other macromolecules are returned to the blood circulation immune cells antigens gain access lymph nodes. Lymph flow is an active process promoted rhythmical contraction-relaxation events occurring in collecting lymphatic vessels. This pumping intrinsic property of muscles vessel wall consequent action potentials. Compromised may affect cell transport, could be particularly detrimental during inflammation....
Codeine-containing compound analgesics (CCCAs) are associated with dependence and, when taken in excess, significant risks of harm. A previous audit showed costs related to admissions for gastrointestinal (GI) complications CCCA. Based on this and other evidence harm, the Australian Therapeutic Goods Administration changed CCCAs prescription only 2018.We aimed identify codeine-related GI whether schedule change 2018 led a reduced clinical financial strain health care system.We conducted an...
Abstract Background and Aims Functional gastrointestinal disorders (FGIDs) impact quality of life represent a significant burden on healthcare services. Guidelines recommend an early, positive diagnosis to reduce harmful over‐investigation in FGID patients. The aim this multicentre study was evaluate management against current guidelines. Methods A multicentre, retrospective evaluation patients with primary across two tertiary gastroenterology services over 12‐month period performed. Time...
The lymphatic system comprises a series of vessels that operate together to maintain tissue fluid homeostasis as well traffic nutrients and immune cells throughout the body. Immune cell trafficking is an important often overlooked function over years, data has amassed which supports its vital role in healthy system. An intact not only involved activation response pathogen, it also ensuring body does exaggerate responses otherwise benign molecules encountered every day. Nowhere this pivotal...
Lymphatic vessels rhythmically contract to actively propel lymph. This function, critical tissue fluid homeostasis and immune cell trafficking is impaired in Crohn's disease the guinea‐pig model of TNBS ileitis, suggesting compromised lymph flow lymphatic potential players disease. Nitric oxide (NO) prostaglandins (PGs), abundantly produced during intestinal inflammation, are known activate ATP‐sensitive potassium (K ATP ) channels expressed muscle. Our aim was assess role K channels, NO PGs...