A5008250133- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Immune responses and vaccinations
- Microbial infections and disease research
- vaccines and immunoinformatics approaches
Centre de Recerca en Sanitat Animal
2018-2022
Universitat Autònoma de Barcelona
2017-2022
Tuberculosis (TB) in animals is a re-emerging disease with wide range of hosts that causes large economic losses livestock. Goats are particularly susceptible to TB and, endemic areas, vaccination may be valuable measure control the disease. The main aim this study was evaluate efficacy parenteral goats heat-inactivated Mycobacterium bovis (HIMB) vaccine, and compare it M. Bacille Calmette-Guérin (BCG) vaccine. Twenty-four goat kids were divided 3 groups as following: HIMB vaccinated group...
Control of animal tuberculosis (TB) through vaccination has emerged as a long-term strategy to complement test and slaughter control strategy. A pilot trial under field conditions was conducted in goat herd with high TB prevalence assess the efficacy Mycobacterium bovis BCG vaccine.Twenty-three kids vaccinated other 22 unvaccinated were euthanized at 18 months post-vaccination. Gross pathological histopathological examination target tissues performed for detection tuberculous lesions...
Current eradication strategies of tuberculosis (TB) in goats mainly rely on the single intradermal tuberculin test (SIT) and cervical comparative tests (SICCTs). TB vaccination has been proposed as a cost-effective option high-prevalence herds or countries where economic compensation for slaughter positive animals is not affordable. However, compromises efficiency tuberculin-based diagnostic tests. In this study, performance new platform, based P22 antigenic complex, was assessed skin (ST),...
Vaccination of goats against tuberculosis (TB) has been promoted as an ancillary tool for controlling the disease in infected livestock herds. A three-year trial to assess efficacy BCG vaccine was carried out five goat At beginning (month 0), all animals were tested TB using thee different diagnostic tests. Animals negative tests vaccinated with and replacement kids also systematically throughout trial. All by Interferon-gamma release assay (IGRA) compatible reagents at months 6, 12, 24, 36....
Voles are maintenance hosts of Mycobacterium microti. In line with the goal to eradicate tuberculosis (TB) in livestock, role this mycobacteria needs be assessed since it might interfere current M. bovis/M. caprae surveillance strategies. To better understand pathogenesis TB voles, an experimental infection model was set up reproduce microti laboratory Bank voles (Myodes glareolus). Two routes (intragastric and intraperitoneal) doses (105 106 CFU/0.1 mL) were assessed. culled at different...
Abstract This study aimed to assess the efficacy of a heat-inactivated Mycobacterium caprae (HIMC) vaccine in goats experimentally challenged with same strain M. . Twenty-one were divided into three groups seven: vaccinated bovis (HIMB), HIMC and unvaccinated. At 7 weeks post-vaccination all animals endobronchially Blood samples collected for immunological assays clinical signs recorded throughout experiment. All euthanized at 9 post-challenge. Gross pathological examination, analysis lung...
Vaccination has been proposed as a supplementary tool for the control of tuberculosis in livestock. The long-term immunogenicity elicited by bacillus Calmette–Guerin (BCG) and efficacy revaccination were investigated thirty goat kids distributed into three groups: unvaccinated controls, BCG (vaccinated at week 0) BCG-BCG weeks 0 56). Sixty-four after first vaccination, all animals challenged with Mycobacterium caprae examined post-mortem (pathology bacterial load) 73. Antigen-specific...