A5019363102- Forensic Toxicology and Drug Analysis
- Psychedelics and Drug Studies
- Opioid Use Disorder Treatment
- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Poisoning and overdose treatments
- Alcohol Consumption and Health Effects
- Mass Spectrometry Techniques and Applications
- Anesthesia and Sedative Agents
- Pharmacology and Obesity Treatment
- Analytical chemistry methods development
- Metabolomics and Mass Spectrometry Studies
- Pain Management and Opioid Use
- Mental Health Research Topics
- Medication Adherence and Compliance
- Biosimilars and Bioanalytical Methods
- Pharmacological Effects and Assays
- Substance Abuse Treatment and Outcomes
- Forensic and Genetic Research
- Forensic Fingerprint Detection Methods
- Analytical Chemistry and Chromatography
Fredric Rieders Family Foundation
2018-2025
National Institute of Justice
2024
RTI International
2024
Institute of Forensic Science
2024
American Academy of Forensic Sciences
2024
National Institute of Standards
2024
National Institute of Standards and Technology
2024
Conference Board
2024
Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that infiltrating heroin market. were reported by Drug Enforcement Administration (DEA) in their third quarter report 2017 to have been chemically identified seven five times, respectively, from drug evidence analyzed DEA's lab system; Q3 was first time system, while methoxyacetylfentanyl one Q2 2017. A method developed using liquid chromatography tandem mass spectrometry for quantitation fentanyl,...
Abstract Identification of N,N-dimethylpentylone (DMP) in counterfeit “Ecstasy” and “Molly” tablets poses risk to public health due its adverse effects. Little information is available regarding the pharmacological activity or relevant blood tissue concentrations DMP, even less known about other structurally related beta-keto methylenedioxyamphetamine analogs on recreational drug markets, such as N-propyl butylone. Here, a novel toxicological assay utilizing liquid chromatography–tandem...
This is the first report regarding characterization of new synthetic cannabinoid 4F-MDMB-BINACA. 4F-MDMB-BINACA was analytically confirmed in seized drug material using gas chromatography-mass spectrometry (GC-MS), liquid chromatography-quadrupole time-of-flight mass (LC-QTOF), and nuclear magnetic resonance (NMR) spectroscopy. Subsequent to this characterization, detected biological specimens collected as part forensically relevant casework, including medicolegal death investigations...
"Ecstasy" and "Molly" are common drug slang terms used among club rave cultures to denote preparations believed contain 3,4-methylenedioxymethamphetamine (MDMA). However, users of Ecstasy Molly have increasingly tested positive for novel psychoactive substances (NPS), notably stimulants. To evaluate hypothesized non-specific interchangeable use the Ecstasy, MDMA, self-reported was compared against toxicological findings in biological specimens. Oral fluid specimens were collected from...
Synthetic cathinones emerged on the novel psychoactive substance (NPS) drug market as alternatives to controlled stimulants and entactogens such methamphetamine 3,4-methylenedioxymethamphetamine. The majority of synthetic can be subclassified into two groups: beta-keto amphetamines (i.e., NPS with suffix "drone") methylenedioxyamphetamines "lone"). Although a significant number have been identified, dominated market, including notable drugs like methylone, butylone, N-ethyl pentylone...
Cocaine use disorder remains a persistent public health dilemma that currently lacks effective treatment strategies. One key impediment to successful outcomes is increased drug craving occurs over the course of abstinence and subsequent relapse use. This phenomenon, known as incubation craving, has been modeled extensively in rodent models intravenous self-administration. As commonly implemented, design self-administration preclinical studies precludes disentangling appetitive consummatory...
The development of comprehensive strategies to understand emerging trends in substance use is necessary design effective prevention and harm reduction for people who drugs (PWUD). Dried blood spots (DBS) can be used as a non-conventional drug testing approach that meets Food Drug Administration (FDA) accuracy precision guidelines. From July 2021 2022, 1,559 PWUD were enrolled at six US syringe service programs (SSP) Sacramento, California, Ellensburg, Washington, Missoula, Montana...
Introduction Non-pharmaceutical fentanyl and its analogs have driven striking increases in opioid-associated overdose deaths. These highly potent opioids can be found at low concentrations biological specimens. Little is known regarding the of these substances among survivors non-fatal overdoses. In a locale where responsible for majority opioid overdoses, we compared concentration blood to naloxone dosing presence absence concurrent sedative-hypnotic exposure.Methods this pilot study,...
Abstract We report the case of a young adult who became unresponsive after insufflating what he believed to be “crushed Xanax.” Naloxone was administered, reversing his altered mental status and respiratory depression. Clinicians suspected opioid toxicity; however, patient adamantly denied use. Because unclear etiology symptoms, blood urine specimens were obtained. A specimen split then submitted for clinical comprehensive drug screen using gas chromatography–mass spectrometry. The remaining...
Abstract 2,4‐dinitrophenol (2,4‐DNP) is a compound used in the early 1900s as weight‐loss drug but later prohibited due to its severe adverse effects, including death. It has however been attracting interest, properties, and appears be re‐emerging forensic casework. As 2,4‐DNP available for use industry pesticide easily accessible online, dissemination of this can fast. The exerts effects through inhibition ATP synthesis, corresponding thermogenic energy loss which fatal. A method...
Abstract Electronic dance music (EDM) festivals have become a popular venue for recreational drug use, including the use of traditional stimulants like 3,4-methylenendioxymethamphetamine (MDMA) and novel psychoactive substances (NPS). Using this cohort people who drugs recreationally, study sought to collect biological specimens self-reported data from EDM festival attendees in United States monitor regional temporal trends related NPS turnover between 2014 2017. Oral fluid samples were...
Abstract 3‐methylfentanyl (3‐MF), N‐ (3‐methyl‐1‐phenethyl‐4‐piperidyl)‐ phenyl‐propanamide, has reappeared on the US illicit drug market since its disappearance after a series of overdose deaths in 1988. 3‐MF presents an analytical challenge, due to presence cis and trans stereoisomers, each with different potencies, ultimately very low concentrations blood use. A method was developed using liquid chromatography–time‐of‐flight–mass spectrometry for analysis (±)‐ ‐3‐MF specimens solid phase...
We report a method for the detection and quantitation of 12 drugs 2 metabolites in same structural class as illicit mu-opioid agonist U-47700 human whole blood. These substances are either known or suspected to be present potential novel opioids drug markets. The general these was developed pharmaceutical research programs 1970s, but have recently become concern overdoses death opioid users USA internationally. scope analysis included following compounds: methylenedioxy U-47700,...
Drug-impaired driving is a significant public health and safety concern in the USA. To help assess current patterns of drug use drivers, we evaluated 4 years positivity large cohort suspected impaired drivers. Samples collected between January 2017 December 2020 were tested via method compliant with National Safety Council's Alcohol, Drugs, Impairment Division's Tier I scope recommended drugs. In 2017, NMS Labs received 17 346 under influence drugs cases, 471 2018, 19 050 2019, 16 539 2020....