A5077792821- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Amyotrophic Lateral Sclerosis Research
- Neural dynamics and brain function
- Colorectal Cancer Treatments and Studies
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Olfactory and Sensory Function Studies
- EEG and Brain-Computer Interfaces
- Drug Transport and Resistance Mechanisms
- Alzheimer's disease research and treatments
- Cancer therapeutics and mechanisms
- Acute Ischemic Stroke Management
- Stuttering Research and Treatment
- Stroke Rehabilitation and Recovery
- Lung Cancer Treatments and Mutations
- Intracerebral and Subarachnoid Hemorrhage Research
- Medical Imaging Techniques and Applications
- Immune Cell Function and Interaction
- Cholinesterase and Neurodegenerative Diseases
- Gastric Cancer Management and Outcomes
- Neuropeptides and Animal Physiology
Nagoya University
2015-2025
Innsbruck Medical University
2022-2025
Fujita Health University
2024-2025
Kyoto University
1991-2024
John Wiley & Sons (United States)
2024
Universität Innsbruck
2022-2023
Japanese Red Cross Nagoya Daini Hospital
2013-2014
Red Cross Hospital
2013
Foundation for Ichthyosis and Related Skin Types
1993
Background: Imaging studies in Alzheimer's disease (AD) have yet to answer the underlying questions concerning relationship among tau retention, neuroinflammation, network disruption and cognitive decline. We compared spatial retention patterns of 18F-THK5351 resting state (RSN) patients with early AD healthy controls. Methods: enrolled 23 11C-Pittsburgh compound B (PiB)-positive 24 11C-PiB-negative participants as All underwent functional MRI PET scans. used scaled subprofile...
Objective Severe hyposmia is a risk factor of dementia in Parkinson's disease (PD), while the underlying functional connectivity (FC) and brain volume alterations PD patients with severe (PD-SH) are unclear. Methods We examined voxel-based morphometric resting state magnetic resonance imaging findings 15 cognitively normal PD-SH, no/mild (PD-N/MH), healthy controls (HCs). Results Decreased gray matter (GMV) was observed bilateral cuneus, right associative visual area, precuneus, some areas...
Abstract White matter (WM) fiber bundles change dynamically with age. These changes could be driven by alterations in axonal diameter, density, and myelin content. In this study, we applied a novel fixel‐based analysis (FBA) framework to examine these throughout the adult lifespan. Using diffusion‐weighted images from cohort of 293 healthy volunteers (89 males/204 females) ages 21 86 years old, performed FBA analyze age‐related microscopic density (FD) macroscopic morphology (fiber cross...
Accumulating evidence from anatomical and neuroimaging studies suggests that the cerebellum is engaged in a variety of motor cognitive tasks. Given its various functions, key question whether also plays an important role brain's integrative functions. Here, we hypothesize existence connector regions, known as hubs, where multiple resting state networks converged cerebellum. To verify this, employed recently developed voxel-level network measure called functional connectivity overlap ratio...
Multiple system atrophy (MSA) is an adult-onset, progressive neurodegenerative disorder. Patients with MSA show various phenotypes during the course of their illness, including parkinsonism, cerebellar ataxia, autonomic failure, and pyramidal signs. sometimes present isolated failure or motor symptoms/ The median duration from onset to concomitant appearance symptoms approximately 2 years but can range up 14 years. As presence both essential for current diagnostic criteria, early diagnosis...
Abstract The aging brain undergoes structural changes even in very healthy individuals. Quantifying these could help disentangle pathologic from those associated with the normal human process. Using longitudinal magnetic resonance imaging (MRI) data 227 carefully selected cohort age ranging 50 to 80 years old at baseline scan, we quantified age-related volumetric of older adults. Longitudinally, rates tissue loss total gray matter (GM) and white (WM) were 2497.5 2579.8 mm 3 per year,...
Dysphagia significantly impacts prognosis in individuals with multiple system atrophy (MSA). While video-based assessments are practical, their limited availability highlights the need for a simple tool such as Severity Scale (DSS) clinical practice. To evaluate utility of DSS assessing dysphagia MSA patients and its correlations indices. We examined 43 using other measures, including Unified Rating (UMSARS) cerebrospinal fluid 5-hydroxyindoleacetic acid levels. As follow-up, 11 underwent...
To investigate trajectories of regional brain volume changes in multiple system atrophy (MSA) and their potential utility as surrogate markers disease progression the cerebellar subtype (MSA-C). Reliable biomarkers for tracking MSA are urgently needed. Although several studies have explored neuroimaging markers, imaging measures that reliable reproducible at individual-level lacking. Longitudinal three-dimensional (3D)-T1 images from cohorts 21 subjects with probable MSA-C, 19...
Neuroimaging studies have shown that the brain is functionally organized into several large-scale networks. Within these networks are regions widely connected to other within and/or outside network. Regions connect networks, known as connector hubs, believed be crucial for information transfer and between-network communication brain. To identify with high connectivity at voxel level, we introduced a novel metric called functional overlap ratio (FCOR), which quantifies spatial extent of...
The thalamus is critical for the brain's integrative hub functions; however, localization and characterization of different thalamic hubs remain unclear. Using a voxel-level network measure called functional connectivity overlap ratio (FCOR), we examined thalamus' association with large-scale resting-state networks (RSNs) to elucidate its connector roles. Connections core-neurocognitive were localized in anterior medial parts, such as anteroventral mediodorsal nuclei areas. Regions...
Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy ameliorates symptoms in patients with essential tremor (ET). How this treatment affects canonical brain networks has not been elucidated. The purpose of study was to clarify changes after MRgFUS ET by analyzing resting-state (RSNs).Fifteen were included study. Left performed all cases, and MR images, including functional MRI (rsfMRI), taken before surgery. images 15 age- sex-matched healthy controls (HCs) also used for...
Objective This study compared the UICC classification with General Rules for Gastric Cancer Study (GRGCS) of Japanese Research Society by analyzing recent results gastric cancer surgery in Japan. Summary Background Data The present stage was published 1987 and GRGCS were 1985. Both are based on surveys conducted early 1970s. Methods survival curves 926 patients, who underwent between 1982 1985 at Kyoto University Hospital its 31 associated hospitals, analyzed according to using SAS computer...
The clinicopathological continuity between amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) is well known. Although ALS demonstrates language symptoms similar to FTLD, including semantic dementia, word reading impairments in have not been studied. "Jukujikun" are Kanji-written words with irregular pronunciation comparable "exception words" useful for detecting deficits Japan. We conducted a cross-sectional study investigate Jukujikun related network changes...
Recent studies have demonstrated that connector hubs, regions considered critical for the flow of information across neural systems, are mostly involved in neurodegenerative dementia. Considering aging can significantly affect brain's intrinsic connectivity, identifying aging's impact on these regions' overall connection strength is important to differentiate changes associated with healthy from disorders. Using resting state functional magnetic resonance imaging data a carefully selected...