A5016912802- Multiple Sclerosis Research Studies
- Immunotherapy and Immune Responses
- Cannabis and Cannabinoid Research
- T-cell and B-cell Immunology
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Cytokine Signaling Pathways and Interactions
- SARS-CoV-2 and COVID-19 Research
- Chronic Lymphocytic Leukemia Research
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic function and diabetes
- Systemic Lupus Erythematosus Research
- Ion channel regulation and function
- Adipose Tissue and Metabolism
- Nicotinic Acetylcholine Receptors Study
- Acute Lymphoblastic Leukemia research
- Allergic Rhinitis and Sensitization
- Cell Adhesion Molecules Research
- interferon and immune responses
- Diabetes Treatment and Management
Queen Mary University of London
2016-2025
AstraZeneca (United Kingdom)
2013-2025
Quadram Institute
2021-2025
Norwich Research Park
2024-2025
University of Connecticut
2023
UConn Health
2023
Manhattan College
2023
Institut Pasteur de Dakar
2021
University College London
2003-2020
National University of Medical Sciences
2020
We provide a demonstration in humans of the principle pharmacometabonomics by showing clear connection between an individual's metabolic phenotype, form predose urinary metabolite profile, and fate standard dose widely used analgesic acetaminophen. Predose postdose profiles were determined (1)H NMR spectroscopy. The spectra statistically analyzed relation to drug excretion detect biomarkers human-gut microbiome cometabolite predictor was identified. Thus, we found that individuals having...
Abstract A recombinant protein corresponding to the Ig-like domain of myelin oligodendrocyte glycoprotein (MOG) and synthetic 15-mer peptides whole MOG molecule with eight amino acid overlaps were screened for their ability induce experimental allergic encephalomyelitis (EAE) in Biozzi AB/H (H-2dq1) SJL (H-2S) mice. Clinical histologic evidence EAE developed after sensitization both In mice at least three epitopes within residues 1-22, 43-57, 134-148 induced clinical EAE, whereas only...
There is growing concern that poor experimental design and lack of transparent reporting contribute to the frequent failure pre-clinical animal studies translate into treatments for human disease. In 2010, Animal Research: Reporting Vivo Experiments (ARRIVE) guidelines were introduced help improve standards. They published in PLOS Biology endorsed by funding agencies publishers their journals, including PLOS, Nature research other top-tier journals. Yet our analysis papers journals indicates...
Metformin, a biguanide derivate, has pleiotropic effects beyond glucose reduction, including improvement of lipid profiles and lowering microvascular macrovascular complications associated with type 2 diabetes mellitus (T2DM). These have been ascribed to adenosine monophosphate-activated protein kinase (AMPK) activation in the liver skeletal muscle. However, metformin are not attenuated when AMPK is knocked out intravenous less effective than oral medication, raising possibility important...
Blood–brain barrier (BBB) dysfunction is a hallmark of neurological conditions such as multiple sclerosis (MS) and stroke. However, the molecular mechanisms underlying neurovascular during BBB breakdown remain elusive. MicroRNAs (miRNAs) have recently emerged key regulators pathogenic responses, although their role in central nervous system (CNS) microvascular disorders largely unknown. We identified miR-155 critical miRNA neuroinflammation at BBB. expressed unit individuals with MS mice...
<h3>Importance</h3> Alemtuzumab, a CD52-depleting monoclonal antibody, effectively inhibits relapsing multiple sclerosis (MS) but is associated with high incidence of secondary B-cell autoimmunities that limit use. These effects may be avoided through control hyperproliferation. <h3>Objective</h3> To investigate whether the data describing effect alemtuzumab on lymphocyte subsets collected during phase 3 trial program reveal mechanisms explaining efficacy and risk for autoimmunity treatment...
The purpose of this study was to investigate the effect disease modifying therapies on immune response severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccines in people with multiple sclerosis (MS).Four hundred seventy-three MS provided one or more dried blood spot samples. Information about coronavirus 2019 (COVID-19) and vaccine history, medical, drug history were extracted from questionnaires medical records. Dried spots eluted tested for antibodies SARS-CoV-2. Antibody...
Abstract Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation vivo, but its quantitative interpretation remains uncertain. We show that TSPO expression increases activated microglia mouse brain disease models does not change a non-human primate model or common human describe genetic divergence the gene promoter, consistent with...
Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that triggered by inflammatory attack of the CNS. As yet there no satisfactory treatment. Using experimental allergic encephalo myelitis (EAE), an animal model multiple sclerosis, we demonstrate cannabinoid system neuroprotective during EAE. Mice deficient in receptor CB1 tolerate and excitotoxic insults poorly develop substantial neurodegeneration following immune In addition, exogenous agonists can provide...
Abstract Tumor necrosis factor (TNF) activity was inhibited during the development of actively‐induced, chronic relapsing experimental allergic encephalomyelitis (CREAE) in Biozzi AB/H mice, using a mouse TNF‐specific (TN3.19.12) antibody and bivalent human p55 p75 TNF receptor‐immunoglobulin (TNFR‐Ig) fusion proteins. The disease could be when repeated doses were administered prior to anticipated onset. It has now also been shown that therapeutic effect is evident even after onset clinical...
Neuroinflammatory diseases, such as multiple sclerosis (MS), result from aberrant leukocyte traffic into the central nervous system (CNS). To breach specialized blood-brain barrier, activated leukocytes interact with CNS endothelial cells (EC) and activate a CD54-mediated signaling pathway controlling Rho GTPase. function correctly requires posttranslational prenylation, this can be inhibited by depleting supply of isoprenoids through inhibition cholesterol synthesis...