A5051539953- Cardiovascular Function and Risk Factors
- Tissue Engineering and Regenerative Medicine
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Cardiomyopathy and Myosin Studies
- Mesenchymal stem cell research
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Viral Infections and Immunology Research
- Cardiac Fibrosis and Remodeling
- Pulmonary Hypertension Research and Treatments
- Pluripotent Stem Cells Research
- Cardiac pacing and defibrillation studies
- Organ and Tissue Transplantation Research
- Congenital Heart Disease Studies
- Muscle Physiology and Disorders
- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Pancreatic function and diabetes
- Cardiac Valve Diseases and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Esophageal Cancer Research and Treatment
- Renal Transplantation Outcomes and Treatments
- Cardiac tumors and thrombi
- Cardiovascular Effects of Exercise
Ljubljana University Medical Centre
2016-2025
Palo Alto University
2019
Stanford University
2019
University of Ljubljana
2004-2017
University Medical Center
2016
Postgraduate School of Molecular Medicine
1996
The aim of the SCIENCE trial was to investigate whether a single treatment with direct intramyocardial injections adipose tissue-derived mesenchymal stromal cells (CSCC_ASCs) safe and improved cardiac function in patients chronic ischaemic heart failure reduced ejection fraction (HFrEF).The study European multicentre, double-blind, placebo-controlled phase II using allogeneic CSCC_ASCs from healthy donors or placebo (2:1 randomization). Main inclusion criteria were New York Heart Association...
<b>Background:</b> Serrated adenomas (SAs) of the colorectum combine architectural features hyperplastic polyps and cytological classical adenomas. Molecular studies comparing SAs suggest that each may be a distinct entity; in particular, it has been proposed microsatellite instability (MSI) distinguishes from colorectal cancers arising them develop along pathway driven by low level (MSI-L). <b>Aims:</b> To define molecular characteristics colorectum. <b>Materials methods:</b> We analysed 39...
Allogeneic stem cell therapy is more logistically suitable compared with autologous for large-scale patient treatment. We aim to investigate the clinical safety and efficacy profile of allogeneic adipose tissue derived mesenchymal stromal product (CSCC_ASC) as an add-on in patients chronic non-ischaemic heart failure reduced left ventricular ejection fraction (HFrEF) < 40%.
Abstract Background Titin truncating variants ( TTN tv-s) are the most common genetic cause of dilated cardiomyopathy (DCM). Only rare tv-s in constitutively expressed exons A-band protein titin associated with DCM according to guidelines, however, studies large cohorts patients suggest that region where is wider, extending at least into I-band. The aim this study was describe molecular pathology Slovenian and clinically characterise recurrent tv. Results We collected all identified using...
Preclinical data in heart failure models suggest that repetitive stem cell therapy may be superior to single-dose administration.We investigated whether administration of CD34+ cells is patients with nonischemic dilated cardiomyopathy.Of 66 cardiomyopathy, New York Heart Association functional class III, and left ventricular ejection fraction (LVEF) <40% enrolled the study, 60 were randomly allocated (group A, n=30) or single-cell B, n=30). Patients received G-CSF (granulocyte...
Abstract We investigated the effects of CD34+ cell therapy on right ventricular (RV) function in patients with nonischemic dilated cardiomyopathy (DCM). enrolled 60 DCM who were randomized to (Stem Cells (SC) Group n = 30), or no (Controls, 30). The SC received granulocyte-colony stimulating factor, and cells collected by apheresis injected transendocardially. Patients followed for 6 months. At baseline, groups did not differ age, gender, left ejection fraction, N-terminal probrain...
The aim of the present study was to evaluate effect long-term swimming exercise in conjunction with a high fat mixed lipid (HFML) diet on colon cancer (CC) development and peroxidation large bowel. We used forty male Wistar rats, which were randomly divided into one control group four groups: sedentary groups fed standard (LFCO) an HFML diet. Corticosterone determined during experiment. After 6 months swimming, rats sacrificed blood, heart, liver, muscle bowel taken for determining activity...
Die infektiös bedingte Ösophagitis ist eine seltene Krankheit, die am häufigsten bei den immunologisch kompromittierten Patienten vorkommt. Es wurde nur über wenige Fälle von multiplen Virusinfektionen berichtet. Wir haben Fall kombinierter Viren Zytomegalovirus (CMV) und Herpes-simplex-Virus-(HSV-)Ösophagitis dargestellt, einer 81-jährigen Patientin, fünf Monate lang wegen extrakapillären Glomerulonephritis mit Steroiden Zytostatika behandelt wurde, aufgetreten ist. Patientin verstarb an...
In the present study 36 esophageal squamous cell papillomas (ESCP), uncommon benign neoplasms of esophagus, were investigated retrospectively for p53 immunoreactivity by using monoclonal antibody PAb 1801. Two ESCPs had previously been found to be human papillomavirus (HPV) type-6-positive.Only very occasional epithelial cells stained in two cases, and three staining was restricted basal cells. Both HPV-positive remained p53-negative.We speculate that these findings are result...
Left ventricular noncompaction cardiomyopathy (LVNC) is a rare hereditary characterized by the formation of an outer compacted and inner noncompacted layer myocardium. The latter prominent trabeculations deep intertrabecular recesses functionally inferior to As there no specific treatment for patients with LVNC who develop heart failure, management these limited many progress advanced stages disease. For data regarding use mechanical circulatory support are scarce. We report case 29-year-old...
ABSTRACT Aims Non‐compaction cardiomyopathy (NCM) is a congenital heart disease characterized by an arrest of the myocardial compaction process. Although NCM patients have impaired formation microvasculature, functional impact these changes remains undefined. We sought to analyse potential correlation between ischemia and failure severity in patients. Methods results enrolled 41 (28 male 13 female), aged 21–70 years. In all patients, we determined left ventricular end‐diastolic volume...
We sought to evaluate the long-term effects of angiotensin receptor blocker-neprilysin inhibitor (ARNI) therapy on reverse remodeling failing myocardium in HFrEF patients.
Noncompaction cardiomyopathy is a rare congenital heart disorder characterized by an arrest of the myocardial compaction process. This results in altered formation coronary microvessels with resulting decrease perfusion. Transendocardial CD34 + cell transplantation has been shown to increase perfusion and function patients non-ischemic failure. In our first-in-man case study, we investigated feasibility, safety clinical effect transendocardial therapy patient noncompaction cardiomyopathy.